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5FRN
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BU of 5frn by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ419 (compound 4c)
Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2015-12-18
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
5FRO
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BU of 5fro by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ446 (compound 4f)
Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2015-12-18
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
5FRM
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BU of 5frm by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-azanylidene-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2015-12-18
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
Acs Chem.Biol., 11, 2016
5MMB
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BU of 5mmb by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p)
Descriptor: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), GLYCEROL, ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2016-12-09
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
J. Med. Chem., 60, 2017
5MMA
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BU of 5mma by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ...
Authors:Maskell, D.P, Pye, V.E, Cherepanov, P.
Deposit date:2016-12-09
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
J. Med. Chem., 60, 2017
6RNY
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BU of 6rny by Molmil
PFV intasome - nucleosome strand transfer complex
Descriptor: DNA (108-MER), DNA (128-MER), DNA (33-MER), ...
Authors:Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A.
Deposit date:2019-05-09
Release date:2019-09-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Nat Commun, 10, 2019
6YRF
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BU of 6yrf by Molmil
Vip3Bc1 tetramer
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I, Arribas Perez, M, Maskell, D.P, George, R.M, Hesketh, E.L, Beales, P.A, Zack, M.D, Berry, C.
Deposit date:2020-04-20
Release date:2021-03-17
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
5LLJ
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BU of 5llj by Molmil
Maedi-Visna virus (MVV) integrase C-terminal domain (residues 220-276)
Descriptor: CHLORIDE ION, Integrase
Authors:Pye, V.E, Maskell, D.P, Cherepanov, P.
Deposit date:2016-07-27
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5MLU
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BU of 5mlu by Molmil
Crystal structure of the PFV GAG CBS bound to a mononucleosome
Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B, ...
Authors:Pye, V.E, Maskell, D.P, Lesbats, P, Cherepanov, P.
Deposit date:2016-12-07
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for spumavirus GAG tethering to chromatin.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7ZPP
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BU of 7zpp by Molmil
Cryo-EM structure of the MVV CSC intasome at 4.5A resolution
Descriptor: Integrase, vDNA, non-transferred strand, ...
Authors:Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2022-04-28
Release date:2022-05-11
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration
Science, 355, 2017
7ABL
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BU of 7abl by Molmil
HBV pgRNA T=4 NCP icosahedral symmetry
Descriptor: Capsid protein
Authors:Patel, N, Clark, S, Weis, E.U, Mata, C.P, Bohon, J, Farquhar, E, Ranson, N.A, Twarock, R, Stockley, P.G.
Deposit date:2020-09-07
Release date:2021-10-27
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus.
Commun Biol, 4, 2021
5T3A
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BU of 5t3a by Molmil
Maedi-Visna virus (MVV) integrase CCD-CTD (residues 60-275)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, integrase
Authors:Cook, N.J, Pye, V.E, Cherepanov, P.
Deposit date:2016-08-25
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5M0R
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BU of 5m0r by Molmil
Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex
Descriptor: integrase, tDNA, vDNA, ...
Authors:Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2016-10-05
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
7ZBN
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BU of 7zbn by Molmil
Cryo-EM structure of the human GS-GN complex in the inhibited state
Descriptor: Glycogen [starch] synthase, muscle, Isoform GN-1 of Glycogenin-1
Authors:Marr, L, Zeqiraj, E.
Deposit date:2022-03-23
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:Mechanism of glycogen synthase inactivation and interaction with glycogenin.
Nat Commun, 13, 2022
7NTX
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BU of 7ntx by Molmil
Vip3Bc1 tetramer in processed, activated state
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I.
Deposit date:2021-03-11
Release date:2021-04-14
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (4.75 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
6R0C
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BU of 6r0c by Molmil
Human-D02 Nucleosome Core Particle with biotin-streptavidin label
Descriptor: DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ...
Authors:Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A.
Deposit date:2019-03-12
Release date:2019-09-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Nat Commun, 10, 2019
6YRG
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BU of 6yrg by Molmil
Vip3Bc1 tetramer in processed, activated state
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I.
Deposit date:2020-04-20
Release date:2021-03-17
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
5NO1
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BU of 5no1 by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ407 (compound 5g)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ...
Authors:Pye, V.E, Cherepanov, P.
Deposit date:2017-04-10
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
J. Med. Chem., 60, 2017

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PDB entries from 2024-03-27

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