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4QVB
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MYCOBACTERIUM TUBERCULOSIS PROTEIN RV1155 IN COMPLEX WITH CO-ENZYME F420
Descriptor:Rv1155 protein, FORMIC ACID, 1,3-PROPANDIOL, ...
Authors:Mashalidis, E.H., Gittis, A.G., Tomczak, A., Abell, C., Barry III, C.E., Garboczi, D.N.
Deposit date:2014-07-14
Release date:2015-02-25
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis.
Protein Sci., 24, 2015
6OYH
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CRYSTAL STRUCTURE OF MRAY BOUND TO CARBACAPRAZAMYCIN
Descriptor:MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-heptadecyl-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine
Authors:Mashalidis, E.H., Lee, S.Y.
Deposit date:2019-05-14
Release date:2019-07-10
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
Nat Commun, 10, 2019
6OYZ
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CRYSTAL STRUCTURE OF MRAY BOUND TO CAPURAMYCIN
Descriptor:MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (2~{S},3~{S},4~{S})-2-[(1~{R})-2-azanyl-1-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-methoxy-4-oxidanyl-oxolan-2-yl]-2-oxidanylidene-ethoxy]-3,4-bis(oxidanyl)-~{N}-[(3~{S})-2-oxidanylideneazepan-3-yl]-3,4-dihydro-2~{H}-pyran-6-carboxamide
Authors:Mashalidis, E.H., Lee, S.Y.
Deposit date:2019-05-15
Release date:2019-07-10
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
Nat Commun, 10, 2019
6OZ6
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CRYSTAL STRUCTURE OF MRAY BOUND TO 3'-HYDROXYMUREIDOMYCIN A
Descriptor:MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (2~{S})-2-[[(2~{S})-1-[[(2~{S},3~{S})-3-[[(2~{S})-2-azanyl-3-(3-hydroxyphenyl)propanoyl]-methyl-amino]-1-[[(~{Z})-[(3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-ylidene]methyl]amino]-1-oxidanylidene-butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]carbamoylamino]-3-(3-hydroxyphenyl)propanoic acid
Authors:Mashalidis, E.H., Lee, S.Y.
Deposit date:2019-05-15
Release date:2019-07-10
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
Nat Commun, 10, 2019
5CKR
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CRYSTAL STRUCTURE OF MRAY IN COMPLEX WITH MURAYMYCIN D2
Descriptor:Phospho-N-acetylmuramoyl-pentapeptide-transferase, Muraymycin D2
Authors:Lee, S.Y., Chung, B.C., Mashalidis, E.H., Tanino, T., Kim, M., Hong, J., Ichikawa, S.
Deposit date:2015-07-15
Release date:2016-03-02
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
Nature, 533, 2016
6BW5
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HUMAN GPT (DPAGT1) IN COMPLEX WITH TUNICAMYCIN
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Tunicamycin, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
Authors:Yoo, J., Kuk, A.C.Y., Mashalidis, E.H., Lee, S.-Y.
Deposit date:2017-12-14
Release date:2018-02-21
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
6BW6
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HUMAN GPT (DPAGT1) H129 VARIANT IN COMPLEX WITH TUNICAMYCIN
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Tunicamycin, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
Authors:Yoo, J., Kuk, A.C.Y., Mashalidis, E.H., Lee, S.-Y.
Deposit date:2017-12-14
Release date:2018-02-21
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
5T77
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CRYSTAL STRUCTURE OF THE MOP FLIPPASE MURJ
Descriptor:Putative lipid II flippase MurJ, CHLORIDE ION, ZINC ION, ...
Authors:Kuk, A.C.Y., Lee, S.-Y.
Deposit date:2016-09-02
Release date:2016-12-28
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
Nat. Struct. Mol. Biol., 24, 2017