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4CKI
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CRYSTAL STRUCTURE OF ONCOGENIC RET TYROSINE KINASE M918T BOUND TO ADENOSINE
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, ADENOSINE
Authors:Plaza-Menacho, I., Barnouin, K., Goodman, K., Martinez-Torres, R.J., Borg, A., Murray-Rust, J., Mouilleron, S., Knowles, P., McDonald, N.Q.
Deposit date:2014-01-06
Release date:2014-03-05
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.116 Å)
Cite:Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Mol. Cell, 53, 2014
4CKJ
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CRYSTAL STRUCTURE OF RET TYROSINE KINASE DOMAIN BOUND TO ADENOSINE
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, ADENOSINE, FORMIC ACID
Authors:Plaza-Menacho, I., Barnouin, K., Goodman, K., Martinez-Torres, R.J., Borg, A., Murray-Rust, J., Mouilleron, S., Knowles, P., McDonald, N.Q.
Deposit date:2014-01-06
Release date:2014-03-05
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Mol. Cell, 53, 2014
4CMD
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THE (R)-SELECTIVE TRANSAMINASE FROM NECTRIA HAEMATOCOCCA
Descriptor:AMINOTRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PYRIDOXAL-5'-PHOSPHATE
Authors:Sayer, C., Isupov, M., Martinez-Torres, R.J., Richter, N., Hailes, H.C., Ward, J., Littlechild, J.
Deposit date:2014-01-16
Release date:2014-03-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:The Substrate Specificity, Enantioselectivity and Structure of the (R)-Selective Amine:Pyruvate Transaminase from Nectria Haematococca.
FEBS J., 281, 2014
4CMF
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THE (R)-SELECTIVE TRANSAMINASE FROM NECTRIA HAEMATOCOCCA WITH INHIBITOR BOUND
Descriptor:AMINOTRANSFERASE, 3-[O-PHOSPHONOPYRIDOXYL]--AMINO-BENZOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Sayer, C., Isupov, M., Martinez-Torres, R.J., Richter, N., Hailes, H.C., Ward, J., Littlechild, J.
Deposit date:2014-01-16
Release date:2014-03-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Substrate Specificity, Enantioselectivity and Structure of the (R)-Selective Amine:Pyruvate Transaminase from Nectria Haematococca.
FEBS J., 281, 2014
5C1Z
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PARKIN (UBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
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PARKIN (S65DUBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ...
Authors:Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5FM2
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CRYSTAL STRUCTURE OF HYPER-PHOSPHORYLATED RET KINASE DOMAIN WITH (PROXIMAL) JUXTAMEMBRANE SEGMENT
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
Authors:Plaza-Menacho, I., Barnouin, K., Barry, R., Borg, A., Orme, M., Mouilleron, S., Martinez-Torres, R.J., Meier, P., McDonald, N.Q.
Deposit date:2015-10-30
Release date:2016-12-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Cell Rep, 17, 2016
5FM3
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CRYSTAL STRUCTURE OF HYPER-PHOSPHORYLATED RET KINASE DOMAIN WITH (PROXIMAL) JUXTAMEMBRANE SEGMENT
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
Authors:Plaza-Menacho, I., Barnouin, K., Barry, R., Borg, A., Orme, M., Mouilleron, S., Martinez-Torres, R.J., Meier, P., McDonald, N.Q.
Deposit date:2015-10-30
Release date:2016-12-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Cell Rep, 17, 2016