Author results

2WAG
  • Download 2wag
  • View 2wag
Molmil generated image of 2wag
THE STRUCTURE OF A FAMILY 25 GLYCOSYL HYDROLASE FROM BACILLUS ANTHRACIS.
Descriptor:LYSOZYME, PUTATIVE, POLYETHYLENE GLYCOL (N=34), ...
Authors:Martinez-Fleites, C., Korczynska, J.E., Cope, M., Turkenburg, J.P., Taylor, E.J.
Deposit date:2009-02-06
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of a Family Gh25 Lysozyme from Bacillus Anthracis Implies a Neighboring-Group Catalytic Mechanism with Retention of Anomeric Configuration
Carbohydr.Res., 344, 2009
2VN6
  • Download 2vn6
  • View 2vn6
Molmil generated image of 2vn6
THE CLOSTRIDIUM CELLULOLYTICUM DOCKERIN DISPLAYS A DUAL BINDING MODE FOR ITS COHESIN PARTNER
Descriptor:SCAFFOLDING PROTEIN, ENDOGLUCANASE A, CALCIUM ION
Authors:Pinheiro, B.A., Prates, J.A.M., Proctor, M.R., Gilbert, H.J., Davies, G.J., Money, V.A., Martinez-Fleites, C., Bayer, E.A., Fontes, C.M.G.A., Fierobe, H.P.
Deposit date:2008-01-31
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The Clostridium Cellulolyticum Dockerin Displays a Dual Binding Mode for its Cohesin Partner.
J.Biol.Chem., 283, 2008
2IW1
  • Download 2iw1
  • View 2iw1
Molmil generated image of 2iw1
CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS
Descriptor:LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN RFAG, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-23
Release date:2006-10-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2IV7
  • Download 2iv7
  • View 2iv7
Molmil generated image of 2iv7
CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS
Descriptor:LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN RFAG, URIDINE-5'-DIPHOSPHATE
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2WH7
  • Download 2wh7
  • View 2wh7
Molmil generated image of 2wh7
THE PARTIAL STRUCTURE OF A GROUP A STREPTPCOCCAL PHAGE-ENCODED TAIL FIBRE HYALURONATE LYASE HYLP2
Descriptor:HYALURONIDASE-PHAGE ASSOCIATED
Authors:Martinez-Fleites, C., Black, G.W., Turkenburg, J.P., Smith, N.L., Taylor, E.J.
Deposit date:2009-05-01
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of Two Truncated Phage-Tail Hyaluronate Lyases from Streptococcus Pyogenes Serotype M1.
Acta Crystallogr.,Sect.F, 65, 2009
4M83
  • Download 4m83
  • View 4m83
Molmil generated image of 4m83
ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURE (2IYF) OF MACROLIDE GLYCOSYLTRANSFERASES OLED COMPLEXED WITH UDP AND ERYTHROMYCIN A
Descriptor:Oleandomycin glycosyltransferase, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Wang, F., Helmich, K.E., Xu, W., Singh, S., Olmos Jr., J.L., Martinez iii, E., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-08-12
Release date:2013-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Crystal structure of macrolide glycosyltransferases OleD
To be Published
2IYA
  • Download 2iya
  • View 2iya
Molmil generated image of 2iya
THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-13
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2IYF
  • Download 2iyf
  • View 2iyf
Molmil generated image of 2iyf
THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-17
Release date:2007-03-27
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2C1X
  • Download 2c1x
  • View 2c1x
Molmil generated image of 2c1x
STRUCTURE AND ACTIVITY OF A FLAVONOID 3-O GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP-GLUCOSE FLAVONOID 3-O GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-09-22
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2C1Z
  • Download 2c1z
  • View 2c1z
Molmil generated image of 2c1z
STRUCTURE AND ACTIVITY OF A FLAVONOID 3-O GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP-GLUCOSE FLAVONOID 3-O GLYCOSYLTRANSFERASE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-09-22
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2VN5
  • Download 2vn5
  • View 2vn5
Molmil generated image of 2vn5
THE CLOSTRIDIUM CELLULOLYTICUM DOCKERIN DISPLAYS A DUAL BINDING MODE FOR ITS COHESIN PARTNER
Descriptor:SCAFFOLDING PROTEIN, ENDOGLUCANASE A, CALCIUM ION
Authors:Pinheiro, B.A., Prates, J.A.M., Proctor, M.R., Gilbert, H.J., Davies, G.J., Money, V.A., Martinez-Fleites, C., Bayer, E.A., Fontes, C.M.G.A., Fierobe, H.P.
Deposit date:2008-01-31
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Clostridium Cellulolyticum Dockerin Displays a Dual Binding Mode for its Cohesin Partner.
J.Biol.Chem., 283, 2008
2WB3
  • Download 2wb3
  • View 2wb3
Molmil generated image of 2wb3
THE PARTIAL STRUCTURE OF A GROUP A STREPTOCOCCAL PHAGE-ENCODED TAIL FIBRE HYALURONATE LYASE HYLP3
Descriptor:HYALURONIDASE-PHAGE ASSOCIATED
Authors:Martinez-Fleites, C., Black, G.W., Turkenburg, J.P., Smith, N.L., Taylor, E.J.
Deposit date:2009-02-20
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Two Truncated Phage-Tail Hyaluronate Lyases from Streptococcus Pyogenes Serotype M1.
Acta Crystallogr.,Sect.F, 65, 2009
2BO4
  • Download 2bo4
  • View 2bo4
Molmil generated image of 2bo4
DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, CITRATE ANION
Authors:Flint, J., Taylor, E., Yang, M., Bolam, D.N., Tailford, L.E., Martinez-Fleites, C., Dodson, E.J., Davis, B.G., Gilbert, H.J., Davies, G.J.
Deposit date:2005-04-07
Release date:2005-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Dissection and High-Throughput Screening of Mannosylglyceerate Synthase
Nat.Struct.Mol.Biol., 12, 2005
2CN3
  • Download 2cn3
  • View 2cn3
Molmil generated image of 2cn3
CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE
Descriptor:BETA-1,4-XYLOGLUCAN HYDROLASE, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE, ...
Authors:Martinez-Fleites, C., Taylor, E.J., Guerreiro, C.I.P.D., Prates, J.A.M., Ferreira, L.M.A., Fontes, C.M.G.A., Baumann, M.J., Brumer, H., Davies, G.J.
Deposit date:2006-05-17
Release date:2006-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Clostridium Thermocellum Xyloglucanase, Xgh74A, Reveal the Structural Basis for Xyloglucan Recognition and Degradation
J.Biol.Chem., 281, 2006
2XED
  • Download 2xed
  • View 2xed
Molmil generated image of 2xed
NOCARDIA FARCINICA MALEATE CIS-TRANS ISOMERASE C194S MUTANT WITH A COVALENTLY BOUND SUCCINYLCYSTEINE INTERMEDIATE
Descriptor:PUTATIVE MALEATE ISOMERASE, SUCCINIC ACID
Authors:Fisch, F., Martinez-Fleites, C., Baudendistel, N., Hauer, B., Turkenburg, J.P., Hart, S., Bruce, N.C., Grogan, G.
Deposit date:2010-05-13
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Covalent Succinylcysteine-Like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase.
J.Am.Chem.Soc., 132, 2010
1UYW
  • Download 1uyw
  • View 1uyw
Molmil generated image of 1uyw
CRYSTAL STRUCTURE OF THE ANTIFLAVIVIRUS FAB4G2
Descriptor:FAB ANTIBODY HEAVY CHAIN, FAB ANTIBODY LIGHT CHAIN
Authors:Martinez-Fleites, C., Ortiz-Lombardia, M., Taylor, E.J., Gil-Valdes, J., Chinea, G., Davies, G.
Deposit date:2004-03-03
Release date:2005-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Antiflavivirus Fab4G2
To be Published
2C9Z
  • Download 2c9z
  • View 2c9z
Molmil generated image of 2c9z
STRUCTURE AND ACTIVITY OF A FLAVONOID 3-0 GLUCOSYLTRANSFERASE REVEALS THE BASIS FOR PLANT NATURAL PRODUCT MODIFICATION
Descriptor:UDP GLUCOSE\:FLAVONOID 3-O-GLUCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE
Authors:Offen, W., Martinez-Fleites, C., Kiat-Lim, E., Yang, M., Davis, B.G., Tarling, C.A., Ford, C.M., Bowles, D.J., Davies, G.J.
Deposit date:2005-12-15
Release date:2006-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of a Flavonoid Glucosyltransferase Reveals the Basis for Plant Natural Product Modification.
Embo J., 25, 2006
2CN2
  • Download 2cn2
  • View 2cn2
Molmil generated image of 2cn2
CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE
Descriptor:BETA-1,4-XYLOGLUCAN HYDROLASE, CADMIUM ION
Authors:Martinez-Fleites, C., Taylor, E.J., Guerreiro, C.I., Prates, J.A.M., Ferreira, L.M.A., Fontes, C.M.G.A., Baumann, M.J., Brumer, H., Davies, G.J.
Deposit date:2006-05-17
Release date:2006-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Clostridium Thermocellum Xyloglucanase, Xgh74A, Reveal the Structural Basis for Xyloglucan Recognition and Degradation.
J.Biol.Chem., 281, 2006
2IUY
  • Download 2iuy
  • View 2iuy
Molmil generated image of 2iuy
CRYSTAL STRUCTURE OF AVIGT4, A GLYCOSYLTRANSFERASE INVOLVED IN AVILAMYCIN A BIOSYNTHESIS
Descriptor:GLYCOSYLTRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2WTX
  • Download 2wtx
  • View 2wtx
Molmil generated image of 2wtx
INSIGHT INTO THE MECHANISM OF ENZYMATIC GLYCOSYLTRANSFER WITH RETENTION THROUGH THE SYNTHESIS AND ANALYSIS OF BISUBSTRATE GLYCOMIMETICS OF TREHALOSE-6-PHOSPHATE SYNTHASE
Descriptor:ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING], 1,2-ETHANEDIOL, ...
Authors:Errey, J.C., Lee, S.S., Gibson, R.P., Martinez-Fleites, C., Barry, C.S., Jung, P.M.J., OSullivan, A., Davis, B.G., Davies, G.J.
Deposit date:2009-09-25
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic Insight Into Enzymatic Glycosyl Transfer with Retention of Configuration Through Analysis of Glycomimetic Inhibitors.
Angew.Chem.Int.Ed.Engl., 49, 2010
2XEC
  • Download 2xec
  • View 2xec
Molmil generated image of 2xec
NOCARDIA FARCINICA MALEATE CIS-TRANS ISOMERASE BOUND TO TRIS
Descriptor:PUTATIVE MALEATE ISOMERASE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION
Authors:Fisch, F., Martinez-Fleites, C., Baudendistel, N., Hauer, B., Turkenburg, J.P., Hart, S., Bruce, N.C., Grogan, G.
Deposit date:2010-05-13
Release date:2010-08-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Covalent Succinylcysteine-Like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase.
J.Am.Chem.Soc., 132, 2010
2VVS
  • Download 2vvs
  • View 2vvs
Molmil generated image of 2vvs
BTGH84 STRUCTURE IN COMPLEX WITH PUGNAC
Descriptor:O-GLCNACASE BT_4395, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Macauley, M.S., Bubb, A., Martinez-Fleites, C., Davies, G.J., Vocadlo, D.J.
Deposit date:2008-06-11
Release date:2008-09-30
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Elevation of Global O-Glcnac Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-Glcnacase Does not Induce Insulin Resistance
J.Biol.Chem., 283, 2008
2IV3
  • Download 2iv3
  • View 2iv3
Molmil generated image of 2iv3
CRYSTAL STRUCTURE OF AVIGT4, A GLYCOSYLTRANSFERASE INVOLVED IN AVILAMYCIN A BIOSYNTHESIS
Descriptor:GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2Y4J
  • Download 2y4j
  • View 2y4j
Molmil generated image of 2y4j
MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, LACTIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2W4X
  • Download 2w4x
  • View 2w4x
Molmil generated image of 2w4x
BTGH84 IN COMPLEX WITH STZ
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, STREPTOZOTOCIN, ...
Authors:He, Y., Bubb, A., Martinez-Fleites, C., Davies, G.J.
Deposit date:2008-12-02
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Insight Into the Mechanism of Streptozotocin Inhibition of O-Glcnacase.
Carbohydr.Res., 344, 2009
<12>