Author results

4M83
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ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURE (2IYF) OF MACROLIDE GLYCOSYLTRANSFERASES OLED COMPLEXED WITH UDP AND ERYTHROMYCIN A
Descriptor:Oleandomycin glycosyltransferase, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Wang, F., Helmich, K.E., Xu, W., Singh, S., Olmos Jr., J.L., Martinez iii, E., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-08-12
Release date:2013-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Crystal structure of macrolide glycosyltransferases OleD
To be Published
2Y4J
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH LACTATE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, LACTIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4K
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH MG-GDP
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4L
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH MANGANESE AND GDP
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MANGANESE (II) ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2Y4M
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MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH GDP-MANNOSE
Descriptor:MANNOSYLGLYCERATE SYNTHASE, MAGNESIUM ION, GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), ...
Authors:Nielsen, M.M., Suits, M.D.L., Yang, M., Barry, C.S., Martinez-Fleites, C., Tailford, L.E., Flint, J.E., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2011-01-07
Release date:2011-02-02
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase.
J.Biol.Chem., 286, 2011
2XEC
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NOCARDIA FARCINICA MALEATE CIS-TRANS ISOMERASE BOUND TO TRIS
Descriptor:PUTATIVE MALEATE ISOMERASE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION
Authors:Fisch, F., Martinez-Fleites, C., Baudendistel, N., Hauer, B., Turkenburg, J.P., Hart, S., Bruce, N.C., Grogan, G.
Deposit date:2010-05-13
Release date:2010-08-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Covalent Succinylcysteine-Like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase.
J.Am.Chem.Soc., 132, 2010
2XED
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NOCARDIA FARCINICA MALEATE CIS-TRANS ISOMERASE C194S MUTANT WITH A COVALENTLY BOUND SUCCINYLCYSTEINE INTERMEDIATE
Descriptor:PUTATIVE MALEATE ISOMERASE, SUCCINIC ACID
Authors:Fisch, F., Martinez-Fleites, C., Baudendistel, N., Hauer, B., Turkenburg, J.P., Hart, S., Bruce, N.C., Grogan, G.
Deposit date:2010-05-13
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Covalent Succinylcysteine-Like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase.
J.Am.Chem.Soc., 132, 2010
2WTX
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INSIGHT INTO THE MECHANISM OF ENZYMATIC GLYCOSYLTRANSFER WITH RETENTION THROUGH THE SYNTHESIS AND ANALYSIS OF BISUBSTRATE GLYCOMIMETICS OF TREHALOSE-6-PHOSPHATE SYNTHASE
Descriptor:ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING], 1,2-ETHANEDIOL, ...
Authors:Errey, J.C., Lee, S.S., Gibson, R.P., Martinez-Fleites, C., Barry, C.S., Jung, P.M.J., OSullivan, A., Davis, B.G., Davies, G.J.
Deposit date:2009-09-25
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic Insight Into Enzymatic Glycosyl Transfer with Retention of Configuration Through Analysis of Glycomimetic Inhibitors.
Angew.Chem.Int.Ed.Engl., 49, 2010
2WH7
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THE PARTIAL STRUCTURE OF A GROUP A STREPTPCOCCAL PHAGE-ENCODED TAIL FIBRE HYALURONATE LYASE HYLP2
Descriptor:HYALURONIDASE-PHAGE ASSOCIATED
Authors:Martinez-Fleites, C., Black, G.W., Turkenburg, J.P., Smith, N.L., Taylor, E.J.
Deposit date:2009-05-01
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of Two Truncated Phage-Tail Hyaluronate Lyases from Streptococcus Pyogenes Serotype M1.
Acta Crystallogr.,Sect.F, 65, 2009
3GKW
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF NIMOTUZUMAB. AN ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY
Descriptor:Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, DI(HYDROXYETHYL)ETHER, ...
Authors:Talavera, A., Friemann, R., Martinez-Fleites, C., Moreno, E., Krengel, U.
Deposit date:2009-03-11
Release date:2009-08-04
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
Cancer Res., 69, 2009
2WB3
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THE PARTIAL STRUCTURE OF A GROUP A STREPTOCOCCAL PHAGE-ENCODED TAIL FIBRE HYALURONATE LYASE HYLP3
Descriptor:HYALURONIDASE-PHAGE ASSOCIATED
Authors:Martinez-Fleites, C., Black, G.W., Turkenburg, J.P., Smith, N.L., Taylor, E.J.
Deposit date:2009-02-20
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Two Truncated Phage-Tail Hyaluronate Lyases from Streptococcus Pyogenes Serotype M1.
Acta Crystallogr.,Sect.F, 65, 2009
2WAG
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THE STRUCTURE OF A FAMILY 25 GLYCOSYL HYDROLASE FROM BACILLUS ANTHRACIS.
Descriptor:LYSOZYME, PUTATIVE, POLYETHYLENE GLYCOL (N=34), ...
Authors:Martinez-Fleites, C., Korczynska, J.E., Cope, M., Turkenburg, J.P., Taylor, E.J.
Deposit date:2009-02-06
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of a Family Gh25 Lysozyme from Bacillus Anthracis Implies a Neighboring-Group Catalytic Mechanism with Retention of Anomeric Configuration
Carbohydr.Res., 344, 2009
2W4X
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BTGH84 IN COMPLEX WITH STZ
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, STREPTOZOTOCIN, ...
Authors:He, Y., Bubb, A., Martinez-Fleites, C., Davies, G.J.
Deposit date:2008-12-02
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Insight Into the Mechanism of Streptozotocin Inhibition of O-Glcnacase.
Carbohydr.Res., 344, 2009
2VVS
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BTGH84 STRUCTURE IN COMPLEX WITH PUGNAC
Descriptor:O-GLCNACASE BT_4395, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Macauley, M.S., Bubb, A., Martinez-Fleites, C., Davies, G.J., Vocadlo, D.J.
Deposit date:2008-06-11
Release date:2008-09-30
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Elevation of Global O-Glcnac Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-Glcnacase Does not Induce Insulin Resistance
J.Biol.Chem., 283, 2008
2VSN
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STRUCTURE AND TOPOLOGICAL ARRANGEMENT OF AN O-GLCNAC TRANSFERASE HOMOLOG: INSIGHT INTO MOLECULAR CONTROL OF INTRACELLULAR GLYCOSYLATION
Descriptor:XCOGT, URIDINE-5'-DIPHOSPHATE
Authors:Martinez-Fleites, C., Macauley, M.S., He, Y., Shen, D., Vocadlo, D., Davies, G.J.
Deposit date:2008-04-28
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15, 2008
2JJM
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CRYSTAL STRUCTURE OF A FAMILY GT4 GLYCOSYLTRANSFERASE FROM BACILLUS ANTHRACIS ORF BA1558.
Descriptor:GLYCOSYL TRANSFERASE, GROUP 1 FAMILY PROTEIN
Authors:Ruane, K.M., Davies, G.J., Martinez-Fleites, C.
Deposit date:2008-04-15
Release date:2008-08-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of a Family Gt4 Glycosyltransferase from Bacillus Anthracis Orf Ba1558.
Proteins, 73, 2008
2VN5
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THE CLOSTRIDIUM CELLULOLYTICUM DOCKERIN DISPLAYS A DUAL BINDING MODE FOR ITS COHESIN PARTNER
Descriptor:SCAFFOLDING PROTEIN, ENDOGLUCANASE A, CALCIUM ION
Authors:Pinheiro, B.A., Prates, J.A.M., Proctor, M.R., Gilbert, H.J., Davies, G.J., Money, V.A., Martinez-Fleites, C., Bayer, E.A., Fontes, C.M.G.A., Fierobe, H.P.
Deposit date:2008-01-31
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Clostridium Cellulolyticum Dockerin Displays a Dual Binding Mode for its Cohesin Partner.
J.Biol.Chem., 283, 2008
2VN6
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THE CLOSTRIDIUM CELLULOLYTICUM DOCKERIN DISPLAYS A DUAL BINDING MODE FOR ITS COHESIN PARTNER
Descriptor:SCAFFOLDING PROTEIN, ENDOGLUCANASE A, CALCIUM ION
Authors:Pinheiro, B.A., Prates, J.A.M., Proctor, M.R., Gilbert, H.J., Davies, G.J., Money, V.A., Martinez-Fleites, C., Bayer, E.A., Fontes, C.M.G.A., Fierobe, H.P.
Deposit date:2008-01-31
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The Clostridium Cellulolyticum Dockerin Displays a Dual Binding Mode for its Cohesin Partner.
J.Biol.Chem., 283, 2008
2IYF
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-17
Release date:2007-03-27
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2IYA
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-13
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2IW1
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CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS
Descriptor:LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN RFAG, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-23
Release date:2006-10-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2IUY
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CRYSTAL STRUCTURE OF AVIGT4, A GLYCOSYLTRANSFERASE INVOLVED IN AVILAMYCIN A BIOSYNTHESIS
Descriptor:GLYCOSYLTRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2IV3
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CRYSTAL STRUCTURE OF AVIGT4, A GLYCOSYLTRANSFERASE INVOLVED IN AVILAMYCIN A BIOSYNTHESIS
Descriptor:GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2IV7
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CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS
Descriptor:LIPOPOLYSACCHARIDE CORE BIOSYNTHESIS PROTEIN RFAG, URIDINE-5'-DIPHOSPHATE
Authors:Martinez-Fleites, C., Proctor, M., Roberts, S., Bolam, D.N., Gilbert, H.J., Davies, G.J.
Deposit date:2006-06-08
Release date:2006-10-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights Into the Synthesis of Lipopolysaccharide and Antibiotics Through the Structures of Two Retaining Glycosyltransferases from Family Gt4
Chem.Biol., 13, 2006
2CN2
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CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE
Descriptor:BETA-1,4-XYLOGLUCAN HYDROLASE, CADMIUM ION
Authors:Martinez-Fleites, C., Taylor, E.J., Guerreiro, C.I., Prates, J.A.M., Ferreira, L.M.A., Fontes, C.M.G.A., Baumann, M.J., Brumer, H., Davies, G.J.
Deposit date:2006-05-17
Release date:2006-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Clostridium Thermocellum Xyloglucanase, Xgh74A, Reveal the Structural Basis for Xyloglucan Recognition and Degradation.
J.Biol.Chem., 281, 2006
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