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4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSC
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSD
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A, R2 protein
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
3JZB
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CRYSTAL STRUCTURE OF TR-ALFA BOUND TO THE SELECTIVE THYROMIMETIC TRIAC
Descriptor:THRA protein, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
Authors:Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R.
Deposit date:2009-09-23
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.007 Å)
Cite:Gaining ligand selectivity in thyroid hormone receptors via entropy.
Proc.Natl.Acad.Sci.USA, 106, 2009
3JZC
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CRYSTAL STRUCTURE OF TR-BETA BOUND TO THE SELECTIVE THYROMIMETIC TRIAC
Descriptor:Thyroid hormone receptor beta, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
Authors:Nascimento, A.S., Dias, S.G.M., Nunes, F.M., Aparicio, R.
Deposit date:2009-09-23
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Gaining ligand selectivity in thyroid hormone receptors via entropy.
Proc.Natl.Acad.Sci.USA, 106, 2009
3ILZ
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STRUCTURE OF TR-ALFA BOUND TO SELECTIVE THYROMIMETIC GC-1 IN P212121 SPACE GROUP
Descriptor:Thyroid hormone receptor, alpha isoform 1 variant, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Authors:Aparicio, R., Polikarpov, L., Bleicher, L.
Deposit date:2009-08-07
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
Bmc Struct.Biol., 8, 2008
3IMY
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STRUCTURE OF TR-BETA BOUND TO SELECTIVE THYROMIMETIC GC-1
Descriptor:Thyroid hormone receptor beta, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Authors:Bleicher, L., Polikarpov, L., Aparicio, R.
Deposit date:2009-08-11
Release date:2009-09-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
BMC STRUCT.BIOL., 8, 2008
3HZF
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STRUCTURE OF TR-ALFA BOUND TO SELECTIVE THYROMIMETIC GC-1 IN C2 SPACE GROUP
Descriptor:Thyroid hormone receptor, alpha isoform 1 variant, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid
Authors:Aparicio, R., Bleicher, L., Polikarpov, I.
Deposit date:2009-06-23
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
Bmc Struct.Biol., 8, 2008
3ILN
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X-RAY STRUCTURE OF THE LAMINARINASE FROM RHODOTHERMUS MARINUS
Descriptor:Laminarinase, GLYCEROL, CALCIUM ION
Authors:Bleicher, L., Golubev, A., Rojas, A.L., Nascimento, A.S., Polikarpov, I.
Deposit date:2009-08-07
Release date:2010-08-18
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular basis of the thermostability and thermophilicity of laminarinases: X-ray structure of the hyperthermostable laminarinase from Rhodothermus marinus and molecular dynamics simulations.
J.Phys.Chem.B, 115, 2011
4EM9
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HUMAN PPAR GAMMA IN COMPLEX WITH NONANOIC ACIDS
Descriptor:Peroxisome proliferator-activated receptor gamma, nonanoic acid, GLYCEROL, ...
Authors:Liberato, M.V., Nascimento, A.S., Polikarpov, I.
Deposit date:2012-04-11
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
4EMA
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HUMAN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH ROSIGLITAZONE
Descriptor:Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)
Authors:Liberato, M.V., Nascimento, A.S., Polikarpov, I.
Deposit date:2012-04-11
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
4LNW
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CRYSTAL STRUCTURE OF TR-ALPHA BOUND TO T3 IN A SECOND SITE
Descriptor:Thyroid hormone receptor alpha, 3,5,3'TRIIODOTHYRONINE
Authors:Puhl, A.C., Aparicio, R., Polikarpov, I.
Deposit date:2013-07-12
Release date:2014-03-19
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
Mol.Endocrinol., 28, 2014
4LNX
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CRYSTAL STRUCTURE OF TR-ALPHA BOUND TO T4 IN A SECOND SITE
Descriptor:Thyroid hormone receptor alpha, 3,5,3',5'-TETRAIODO-L-THYRONINE, 3,5,3'TRIIODOTHYRONINE
Authors:Puhl, A.C., Aparicio, R., Polikarpov, I.
Deposit date:2013-07-12
Release date:2014-03-19
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
Mol.Endocrinol., 28, 2014