Author results

6QEY
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IMP1 KH1 AND KH2 DOMAINS CREATE A STRUCTURAL PLATFORM WITH UNIQUE RNA RECOGNITION AND RE-MODELLING PROPERTIES
Descriptor:Insulin-like growth factor 2 mRNA-binding protein 1, ACETONITRILE, PHOSPHATE ION
Authors:Dagil, R., Ball, N.J., Ogrodowicz, R.W., Purkiss, A.G., Taylor, I.A., Ramos, A.
Deposit date:2019-01-09
Release date:2019-03-27
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.
Nucleic Acids Res., 47, 2019
6FLN
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CRYSTAL STRUCTURE OF THE HUMAN TRIM25 COILED-COIL AND PRYSPRY DOMAINS
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25
Authors:Cusack, S., Lethier, M.
Deposit date:2018-01-26
Release date:2018-05-23
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
6FLM
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CRYSTAL STRUCTURE OF THE HUMAN TRIM25 PRYSPRY DOMAIN
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, SULFATE ION, CHLORIDE ION
Authors:Cusack, S., Kowalinski, E.
Deposit date:2018-01-26
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
6ES4
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A CRYPTIC RNA-BINDING DOMAIN MEDIATES SYNCRIP RECOGNITION AND EXOSOMAL PARTITIONING OF MIRNA TARGETS
Descriptor:Syncrip, isoform K, SULFATE ION, ...
Authors:Hobor, F., Dallmann, A., Ball, N.J., Cicchini, C., Battistelli, C., Ogrodowicz, R.W., Christodoulou, E., Martin, S.R., Castello, A., Tripodi, M., Taylor, I.A., Ramos, A.
Deposit date:2017-10-19
Release date:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.
Nat Commun, 9, 2018
5OV3
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STRUCTURE OF THE RBBP5 BETA-PROPELLER DOMAIN
Descriptor:Retinoblastoma-binding protein 5, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
Authors:Mittal, A., Zhang, Y., Gamblin, S.J., Wilson, J.R.
Deposit date:2017-08-27
Release date:2018-03-28
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
5NT2
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COMPLEX OF INFLUENZA A NS1 WITH TRIM25 COILED COIL DOMAIN
Descriptor:Non-structural protein 1, E3 ubiquitin/ISG15 ligase TRIM25
Authors:Koliopoulos, M.G., Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-23
Method:X-RAY DIFFRACTION (4.259 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
5NT1
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COMPLEX OF INFLUENZA A NS1 EFFECTOR DOMAIN WITH TRIM25 COILED COIL
Descriptor:E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:Koliopoulos, M.G., Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
5JW5
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STRUCTURE OF MEDI8852 FAB FRAGMENT
Descriptor:MEDI8852 Heavy chain, MEDI8852 Light chain, PHOSPHATE ION
Authors:Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2016-05-11
Release date:2016-08-03
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5JW4
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STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H5 HA
Descriptor:Hemagglutinin, MEDI8852 heavy chain, MEDI8852 light chain, ...
Authors:Neu, U., Collins, P.J., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2016-05-11
Release date:2016-08-03
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5JW3
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STRUCTURE OF MEDI8852 FAB FRAGMENT IN COMPLEX WITH H7 HA
Descriptor:Hemagglutinin, MEDI8852 heavy chain, MEDI8852 light chain, ...
Authors:Collins, P.J., Neu, U., Walker, P.A., Vorlaender, M.K., Ogrodowicz, R.W., Martin, S.R., Gamblin, S.J., Skehel, J.J.
Deposit date:2016-05-11
Release date:2016-08-03
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Cell, 166, 2016
5HYN
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH ONCOGENIC HISTONE H3K27M PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Zhang, Y., Justin, N., Wilson, J.R., Gamblin, S.J.
Deposit date:2016-02-01
Release date:2016-05-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
5AJM
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H5 (VN1194) ASN186LYS MUTANT HAEMAGGLUTININ IN COMPLEX WITH AVIAN RECEPTOR ANALOGUE 3'SLN
Descriptor:HAEMAGGLUTININ HA1, HAEMAGGLUTININ HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xiong, X., Xiao, H., Martin, S.R., Coombs, P.J., Liu, J., Collins, P.J., Vachieri, S.G., Walker, P.A., Lin, Y.P., McCauley, J.W., Gamblin, S.J., Skehel, J.J.
Deposit date:2015-02-25
Release date:2015-03-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Enhanced Human Receptor Binding by H5 Haemagglutinins.
Virology, 456, 2014
5A3I
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CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN FLD194 FAB AND TRANSMISSIBLE MUTANT H5 HAEMAGGLUTININ
Descriptor:HEMAGGLUTININ, ANTI-HAEMAGGLUTININ HA1 FAB HEAVY CHAIN, ANTI-HAEMAGGLUTININ HA1 FAB LIGHT CHAIN, ...
Authors:Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S.R., Lin, Y.P., Walker, P.A., Collins, P.J., Monne, I., Suguitan Jr, A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J.J.
Deposit date:2015-06-01
Release date:2015-07-22
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structures of Complexes Formed by H5 Influenza Hemagglutinin with a Potent Broadly Neutralizing Human Monoclonal Antibody.
Proc.Natl.Acad.Sci.USA, 112, 2015
4UOA
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ MET29ILE MUTANT
Descriptor:HA1, HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO9
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ SER30THR MUTANT
Descriptor:HA1, HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO8
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ IN COMPLEX WITH 6SO4-3SLN
Descriptor:HA1, HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO7
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ IN COMPLEX WITH 6SO4 SIALYL LEWIS X
Descriptor:HAEMAGGLUTININ HA1, HAEMAGGLUTININ HA2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO6
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ IN COMPLEX WITH SIALYL LEWIS X
Descriptor:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO5
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ IN COMPLEX WITH 3SLN
Descriptor:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO4
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STRUCTURE OF THE A_CANINE_COLORADO_17864_06 H3 HAEMAGGLUTININ
Descriptor:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO3
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ MUTANT SER30THR
Descriptor:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, ALPHA-L-FUCOSE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO2
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ IN COMPLEX WITH SIALYL LEWIS X
Descriptor:H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO1
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ IN COMPLEX WITH 3SLN
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UO0
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STRUCTURE OF THE A_EQUINE_RICHMOND_07 H3 HAEMAGGLUTININ
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UNZ
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STRUCTURE OF THE A_EQUINE_NEWMARKET_2_93 H3 HAEMAGGLUTININ IN COMPLEX WITH 6SO4-SIALYL LEWIS X
Descriptor:HAY SUBUNIT OF HAEMAGGLUTININ, H3 HAEMAGGLUTININ HA2 CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recent Evolution of Equine Influenza and the Origin of Canine Influenza.
Proc.Natl.Acad.Sci.USA, 111, 2014