Author results

1ERM
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X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHANE BORONIC ACID
Descriptor:TEM-1 BETA-LACTAMASE, 1(R)-1-ACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
Authors:Ness, S., Martin, R., Kindler, A.M., Paetzel, M., Gold, M., Jones, J.B., Strynadka, N.C.J.
Deposit date:2000-04-06
Release date:2000-05-10
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
1GJO
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THE FGFR2 TYROSINE KINASE DOMAIN
Descriptor:FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION
Authors:Ceska, T.A., Owens, R., Doyle, C., Hamlyn, P., Crabbe, T., Moffat, D., Davis, J., Martin, R., Perry, M.J.
Deposit date:2001-07-31
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Fgfr2 Tyrosine Kinase Domain
To be Published
1OEC
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FGFR2 KINASE DOMAIN
Descriptor:FIBROBLAST GROWTH FACTOR RECEPTOR 2, SULFATE ION, 4-ARYL-2-PHENYLAMINO PYRIMIDINE
Authors:Ceska, T.A., Owens, R., Doyle, C., Hamlyn, P., Crabbe, T., Moffat, D., Davis, J., Martin, R., Perry, M.J.
Deposit date:2003-03-24
Release date:2004-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Fgfr2 Tyrosine Kinase Domain in Complex with 4-Aryl-2-Phenylamino Pyrimidine Angiogenesis Inhibitors
To be Published
2JHR
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CRYSTAL STRUCTURE OF MYOSIN-2 MOTOR DOMAIN IN COMPLEX WITH ADP- METAVANADATE AND PENTABROMOPSEUDILIN
Descriptor:MYOSIN-2 HEAVY CHAIN, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Fedorov, R., Boehl, M., Tsiavaliaris, G., Hartmann, F.K., Baruch, P., Brenner, B., Martin, R., Knoelker, H.J., Gutzeit, H.O., Manstein, D.J.
Deposit date:2008-03-25
Release date:2009-01-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity.
Nat.Struct.Mol.Biol., 16, 2009
2JJ9
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CRYSTAL STRUCTURE OF MYOSIN-2 IN COMPLEX WITH ADP-METAVANADATE
Descriptor:MYOSIN-2 HEAVY CHAIN, ADP METAVANADATE, MAGNESIUM ION
Authors:Fedorov, R., Boehl, M., Tsiavaliaris, G., Hartmann, F.K., Baruch, P., Brenner, B., Martin, R., Knoelker, H.J., Gutzeit, H.O., Manstein, D.J.
Deposit date:2008-03-25
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity.
Nat.Struct.Mol.Biol., 16, 2009
2LCQ
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SOLUTION STRUCTURE OF THE ENDONUCLEASE NOB1 FROM P.HORIKOSHII
Descriptor:Putative toxin VapC6, ZINC ION
Authors:Veith, T., Martin, R., Wurm, J.P., Weis, B., Duchardt-Ferner, E., Safferthal, C., Hennig, R., Mirus, O., Bohnsack, M.T., Woehnert, J., Schleiff, E.
Deposit date:2011-05-05
Release date:2011-12-14
Last modified:2012-05-09
Method:SOLUTION NMR
Cite:Structural and functional analysis of the archaeal endonuclease Nob1.
Nucleic Acids Res., 40, 2012
2XEL
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MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY
Descriptor:MYOSIN-2 HEAVY CHAIN, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Chinthalapudi, K., Taft, M.H., Martin, R., Hartmann, F.K., Heissler, S.M., Tsiavaliaris, G., Gutzeit, H.O., Knoelker, H.J., Coluccio, L.M., Fedorov, R., Manstein, D.J.
Deposit date:2010-05-16
Release date:2011-06-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
1ERO
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X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
Descriptor:TEM-1 BETA-LACTAMASE, (1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
Authors:Ness, S., Martin, R., Kindler, A.M., Paetzel, M., Gold, M., Jones, J.B., Strynadka, N.C.J.
Deposit date:2000-04-06
Release date:2000-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
1ERQ
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X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID
Descriptor:TEM-1 BETA-LACTAMASE, 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID
Authors:Ness, S., Martin, R., Kindler, A.M., Paetzel, M., Gold, M., Jones, J.B., Strynadka, N.C.J.
Deposit date:2000-04-06
Release date:2000-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry, 39, 2000
1FV1
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STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES
Descriptor:MAJOR HISTOCOMPATIBILITY COMPLEX ALPHA CHAIN, MAJOR HISTOCOMPATIBILITY COMPLEX BETA CHAIN, MYELIN BASIC PROTEIN, ...
Authors:Li, H., Mariuzza, A.R., Li, Y., Martin, R.
Deposit date:2000-09-18
Release date:2000-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.
J.Mol.Biol., 304, 2000
1ZGL
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CRYSTAL STRUCTURE OF 3A6 TCR BOUND TO MBP/HLA-DR2A
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, major histocompatibility complex, ...
Authors:Li, Y., Huang, Y., Lue, J., Quandt, J.A., Martin, R., Mariuzza, R.A.
Deposit date:2005-04-21
Release date:2005-10-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
Embo J., 24, 2005
2XO8
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CRYSTAL STRUCTURE OF MYOSIN-2 IN COMPLEX WITH TRIBROMODICHLOROPSEUDILIN
Descriptor:MYOSIN-2 HEAVY CHAIN, 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, ...
Authors:Preller, M., Chinthalapudi, K., Martin, R., Knoelker, H.J., Manstein, D.J.
Deposit date:2010-08-10
Release date:2011-05-25
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011
3O6F
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CRYSTAL STRUCTURE OF A HUMAN AUTOIMMUNE TCR MS2-3C8 BOUND TO MHC CLASS II SELF-LIGAND MBP/HLA-DR4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y., Li, Y., Martin, R., Mariuzza, R.A.
Deposit date:2010-07-29
Release date:2011-03-02
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
Embo J., 30, 2011
456C
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CRYSTAL STRUCTURE OF COLLAGENASE-3 (MMP-13) COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID
Descriptor:MMP-13, ZINC ION, CALCIUM ION, ...
Authors:Lovejoy, B., Welch, A., Carr, S., Luong, C., Broka, C., Hendricks, R.T., Campbell, J., Walker, K., Martin, R., Van Wart, H., Browner, M.F.
Deposit date:1998-08-06
Release date:1999-08-06
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
Nat.Struct.Biol., 6, 1999
4NAI
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ARABIDOPSIS THALIANA ISPD APO
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, CADMIUM ION, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAK
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH PENTABROMO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, PENTABROMOPSEUDILIN, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAL
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH TRIBROMODICHLORO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NAN
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ARABIDOPSIS THALIANA ISPD IN COMPLEX WITH TETRABROMO-PSEUDILIN
Descriptor:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 2-bromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol, ...
Authors:Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.-J., Fischer, M., Bacher, A., Groll, M., Diederich, F.
Deposit date:2013-10-22
Release date:2014-01-29
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Angew.Chem.Int.Ed.Engl., 53, 2014
5WNW
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CHAPERONE SPY BOUND TO IM7 6-45 ENSEMBLE
Descriptor:Periplasmic chaperone Spy, Colicin-E7 immunity protein, IMIDAZOLE, ...
Authors:Horowitz, S., Salmon, L., Koldewey, P., Ahlstrom, L.S., Martin, R., Xu, Q., Afonine, P.V., Trievel, R.C., Brooks, C.L., Bardwell, J.C.A.
Deposit date:2017-08-01
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Visualizing chaperone-assisted protein folding.
Nat. Struct. Mol. Biol., 23, 2016
5WO1
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CHAPERONE SPY H96L BOUND TO IM7 L18A L19A L37A (IM7 UN-MODELED)
Descriptor:Periplasmic chaperone Spy, IMIDAZOLE, ZINC ION, ...
Authors:Horowitz, S., Koldewey, P., Martin, R., Bardwell, J.C.A.
Deposit date:2017-08-01
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Visualizing chaperone-assisted protein folding.
Nat. Struct. Mol. Biol., 23, 2016
5WO2
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CHAPERONE SPY BOUND TO CASEIN FRAGMENT (CASEIN UN-MODELED)
Descriptor:Periplasmic chaperone Spy, IMIDAZOLE, ZINC ION, ...
Authors:Horowitz, S., Koldewey, P., Martin, R., Bardwell, J.C.A.
Deposit date:2017-08-01
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Visualizing chaperone-assisted protein folding.
Nat. Struct. Mol. Biol., 23, 2016
5WO3
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CHAPERONE SPY BOUND TO IM7 (IM7 UN-MODELED)
Descriptor:Periplasmic chaperone Spy, ZINC ION, CHLORIDE ION, ...
Authors:Horowitz, S., Koldewey, P., Martin, R., Bardwell, J.C.A.
Deposit date:2017-08-01
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Visualizing chaperone-assisted protein folding.
Nat. Struct. Mol. Biol., 23, 2016
830C
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COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID
Descriptor:MMP-13, ZINC ION, CALCIUM ION, ...
Authors:Lovejoy, B., Welch, A., Carr, S., Luong, C., Broka, C., Hendricks, R.T., Campbell, J., Walker, K., Martin, R., Van Wart, H., Browner, M.F.
Deposit date:1998-08-06
Release date:1999-08-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
Nat.Struct.Biol., 6, 1999
966C
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CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID
Descriptor:MMP-1, ZINC ION, CALCIUM ION, ...
Authors:Lovejoy, B., Welch, A., Carr, S., Luong, C., Broka, C., Hendricks, R.T., Campbell, J., Walker, K., Martin, R., Van Wart, H., Browner, M.F.
Deposit date:1998-08-07
Release date:1999-08-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors.
Nat.Struct.Biol., 6, 1999
4GLI
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CRYSTAL STRUCTURE OF HUMAN SMN YG-DIMER
Descriptor:Maltose-binding periplasmic protein, Survival motor neuron protein chimera
Authors:Martin, R.S., Perry, K., Van Duyne, G.D.
Deposit date:2012-08-14
Release date:2012-10-17
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:The survival motor neuron protein forms soluble glycine zipper oligomers.
Structure, 20, 2012
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