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3L6J
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STRUCTURE OF CINACIGUAT (BAY 58-2667) BOUND TO NOSTOC H-NOX DOMAIN
Descriptor:Alr2278 protein, 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid
Authors:Martin, F., van den Akker, F.
Deposit date:2009-12-23
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.
J.Biol.Chem., 285, 2010
4IAE
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CRYSTAL STRUCTURE OF BAY 60-2770 BOUND TO NOSTOC H-NOX DOMAIN
Descriptor:Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION
Authors:Kumar, V., van den Akker, F., Martin, F.
Deposit date:2012-12-06
Release date:2013-11-20
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
Biochemistry, 52, 2013
5OWP
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CRYSTAL STRUCTURE OF GLYCOPEPTIDE "GVTSAFPDT*RPAP" IN COMPLEX WITH SCFV-SM3
Descriptor:Ig heavy chain V-III region J606,Ig lambda-1 chain V region H2020, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, 1,2-ETHANEDIOL, ...
Authors:Bermejo, I.A., Albuquerque, I.S., Somovilla, V.J., Martinez-Saez, N., Castro-Lopez, J., Garcia-Martin, F., Hinou, H., Nishimura, S., Jimenez-Barbero, J., Asensio, J.L., Avenoza, A., Busto, J.H., Hurtado-Guerrero, R., Peregrina, J.M., Bernardes, G.J., Corzana, F.
Deposit date:2017-09-02
Release date:2017-12-13
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.
J. Am. Chem. Soc., 139, 2017
1U1Z
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THE STRUCTURE OF (3R)-HYDROXYACYL-ACP DEHYDRATASE (FABZ)
Descriptor:(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase, SULFATE ION
Authors:Kimber, M.S., Martin, F., Lu, Y., Houston, S., Vedadi, M., Dharamsi, A., Fiebig, K.M., Schmid, M., Rock, C.O.
Deposit date:2004-07-16
Release date:2004-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa
J.Biol.Chem., 279, 2004
3O6G
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LIGAND-BINDING DOMAIN OF GLUA2 (FLIP) IONOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH AN ALLOSTERIC MODULATOR
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ...
Authors:Maclean, J.K.F., Campbell, R.A., Cumming, I.A., Gillen, K.J., Gillespie, J., Jamieson, C., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A.J., Martin, F., Moir, E.M., Morrow, J.A., Pantling, J., Rankovic, Z., Smith, L.
Deposit date:2010-07-29
Release date:2010-09-15
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20, 2010
3O6H
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LIGAND-BINDING DOMAIN OF GLUA2 (FLIP) IONOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH AN ALLOSTERIC MODULATOR
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ...
Authors:Maclean, J.K.F., Campbell, R.A., Cumming, I.A., Gillen, K.J., Gillespie, J., Jamieson, C., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A.J., Martin, F., Moir, E.M., Morrow, J.A., Pantling, J., Rankovic, Z., Smith, L.
Deposit date:2010-07-29
Release date:2010-09-15
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20, 2010
3O6I
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LIGAND-BINDING DOMAIN OF GLUA2 (FLIP) IONOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH AN ALLOSTERIC MODULATOR
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ...
Authors:Maclean, J.K.F., Campbell, R.A., Cumming, I.A., Gillen, K.J., Gillespie, J., Jamieson, C., Kazemier, B., Kiczun, M., Lamont, Y., Lyons, A.J., Martin, F., Moir, E.M., Morrow, J.A., Pantling, J., Rankovic, Z., Smith, L.
Deposit date:2010-07-29
Release date:2010-09-15
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20, 2010
5LXQ
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STRUCTURE OF PRL-1 IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM2
Descriptor:Protein tyrosine phosphatase type IVA 1, Metal transporter CNNM2, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:GIMENEZ-Mascarell, P., Oyenarte, I., Hardy, S., Breiderhoff, T., Stuiver, M., Kostantin, E., Diercks, T., Pey, A.L., Ereno-ORBEA, J., Martinez-Chantar, M.L., Khalaf-Nazzal, R., Claverie-Martin, F., Muller, D., Tremblay, M., Martinez-Cruz, L.A.
Deposit date:2016-09-22
Release date:2016-12-07
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.335 Å)
Cite:Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J. Biol. Chem., 292, 2017
5MMZ
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STRUCTURE OF PRL-1 IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM2
Descriptor:Metal transporter CNNM2, Protein tyrosine phosphatase type IVA 1
Authors:Gimenez-Mascarell, P., Oyenarte, I., Hardy, S., Breiderhoff, T., Stuiver, M., Kostantin, E., Diercks, T., Pey, A.L., Ereno-Orbea, J., Martinez-Chantar, M.L., Khalaf-Nazzal, R., Claverie-Martin, F., Muller, D., Tremblay, M.L., Martinez-Cruz, L.A.
Deposit date:2016-12-12
Release date:2016-12-21
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J. Biol. Chem., 292, 2017
2NAB
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NIZP1-C2HR ZINC FINGER STRUCTURE
Descriptor:Zinc finger protein 496, ZINC ION
Authors:Berardi, A., Quilici, G., Spiliotopoulos, D., Corral-Rodriguez, M., Martin, F., Degano, M., Tonon, G., Musco, G.
Deposit date:2015-12-22
Release date:2016-03-09
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.
Nucleic Acids Res., 44, 2016
4IAH
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CRYSTAL STRUCTURE OF BAY 60-2770 BOUND C139A H-NOX DOMAIN WITH S-NITROSYLATED CONSERVED C122
Descriptor:Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION
Authors:Kumar, V., van den Akker, F.
Deposit date:2012-12-06
Release date:2013-11-20
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
Biochemistry, 52, 2013
4IAM
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CRYSTAL STRUCTURE OF THE C139A MUTANT OF NOSTOC H-NOX DOMAIN
Descriptor:Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, MALONATE ION
Authors:Kumar, V., van den Akker, F.
Deposit date:2012-12-06
Release date:2013-11-20
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
Biochemistry, 52, 2013
1ASZ
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THE ACTIVE SITE OF YEAST ASPARTYL-TRNA SYNTHETASE: STRUCTURAL AND FUNCTIONAL ASPECTS OF THE AMINOACYLATION REACTION
Descriptor:T-RNA (75-MER), ASPARTYL-tRNA SYNTHETASE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Cavarelli, J., Rees, B., Thierry, J.C., Moras, D.
Deposit date:1995-01-19
Release date:1995-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction.
EMBO J., 13, 1994
1ZD1
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HUMAN SULFORTRANSFERASE SULT4A1
Descriptor:Sulfotransferase 4A1, GLYCEROL
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2AD1
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HUMAN SULFOTRANSFERASE SULT1C2
Descriptor:Sulfotransferase 1C2
Authors:Dong, A., Dombrovski, L., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-07-19
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2BZG
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CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.
Descriptor:THIOPURINE S-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Battaile, K.P., Wu, H., Zeng, H., Loppnau, P., Dong, A., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2005-08-17
Release date:2005-08-25
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural Basis of Allele Variation of Human Thiopurine-S-Methyltransferase.
Proteins, 67, 2007
2GWH
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HUMAN SULFOTRANFERASE SULT1C2 IN COMPLEX WITH PAP AND PENTACHLOROPHENOL
Descriptor:Sulfotransferase 1C2, ADENOSINE-3'-5'-DIPHOSPHATE, PENTACHLOROPHENOL, ...
Authors:Tempel, W., Pan, P.W., Dombrovski, L., Allali-Hassani, A., Vedadi, M., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-05-04
Release date:2006-05-16
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2H11
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AMINO-TERMINAL TRUNCATED THIOPURINE S-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:Thiopurine S-methyltransferase, THIOCYANATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Horton, J.R., Cheng, X.
Deposit date:2006-05-15
Release date:2006-11-21
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis of allele variation of human thiopurine-S-methyltransferase.
Proteins, 67, 2007
2H8K
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HUMAN SULFOTRANFERASE SULT1C3 IN COMPLEX WITH PAP
Descriptor:SULT1C3 splice variant d, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Tempel, W., Dombrovski, L., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-06-07
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
2H9L
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WDR5DELTA23
Descriptor:WD-repeat protein 5, SULFATE ION
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Martin, F., Loppnau, P., Vedadi, M., Weigelt, J., Sundstrom, M., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-06-10
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
2H9M
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WDR5 IN COMPLEX WITH UNMODIFIED H3K4 PEPTIDE
Descriptor:WD-repeat protein 5, H3 histone
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Martin, F., Loppnau, P., Vedadi, M., Weigelt, J., Sundstrom, M., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-06-10
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
2H9N
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WDR5 IN COMPLEX WITH MONOMETHYLATED H3K4 PEPTIDE
Descriptor:WD-repeat protein 5, H3 histone
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Martin, F., Loppnau, P., Vedadi, M., Weigelt, J., Sundstrom, M., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-06-10
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
2H9P
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WDR5 IN COMPLEX WITH TRIMETHYLATED H3K4 PEPTIDE
Descriptor:WD-repeat protein 5, H3 histone
Authors:Min, J.R., Schuetz, A., Allali-Hassani, A., Martin, F., Loppnau, P., Vedadi, M., Weigelt, J., Sundstrom, M., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2006-06-10
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
2HFF
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CRYSTAL STRUCTURE OF CB2 FAB
Descriptor:CB2 Fab, light chain, heavy chain
Authors:Hymowitz, S.G.
Deposit date:2006-06-23
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
2HFG
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CRYSTAL STRUCTURE OF HBR3 BOUND TO CB3S-FAB
Descriptor:CB3s Fab light chain (kappa), CB3s Fab heavy chain, Tumor necrosis factor receptor superfamily member 13C
Authors:Hymowitz, S.G.
Deposit date:2006-06-23
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
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