Author results

1DMI
  • Download 1dmi
  • View 1dmi
Molmil generated image of 1dmi
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6S-H4B
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Kotsonis, P., Pfleiderer, W., Schmidt, H.H.H.W., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-12-14
Release date:2000-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with the Pterin Analogues
To be Published
1DMJ
  • Download 1dmj
  • View 1dmj
Molmil generated image of 1dmj
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Kotsonis, P., Frohlich, L.G., Raman, C.S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N., Taghavi-Moghadam, S., Mohr, D., Munch, U., Schnabel, J., Martasek, P., Masters, B.S., Strobel, H., Poulos, T., Matter, H., Pfleiderer, W., Schmidt, H.H.
Deposit date:1999-12-14
Release date:2000-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
J.Biol.Chem., 276, 2001
1DMK
  • Download 1dmk
  • View 1dmk
Molmil generated image of 1dmk
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-AMINO-6-PHENYL-TETRAHYDROPTERIDINE
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Kotsonis, P., Frohlich, L.G., Raman, C.S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N., Taghavi-Moghadam, S., Mohr, D., Munch, U., Schnabel, J., Martasek, P., Masters, B.S., Strobel, H., Poulos, T., Matter, H., Pfleiderer, W., Schmidt, H.H.
Deposit date:1999-12-14
Release date:2000-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
J.Biol.Chem., 276, 2001
1D0C
  • Download 1d0c
  • View 1d0c
Molmil generated image of 1d0c
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 3-BROMO-7-NITROINDAZOLE (H4B FREE)
Descriptor:BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-09
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry, 40, 2001
1D0O
  • Download 1d0o
  • View 1d0o
Molmil generated image of 1d0o
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 3-BROMO-7-NITROINDAZOLE (H4B PRESENT)
Descriptor:BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-13
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry, 40, 2001
1D1V
  • Download 1d1v
  • View 1d1v
Molmil generated image of 1d1v
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA (H4B BOUND)
Descriptor:BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-21
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
J.Biol.Chem., 276, 2001
1D1W
  • Download 1d1w
  • View 1d1w
Molmil generated image of 1d1w
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 2-AMINOTHIAZOLINE (H4B BOUND)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, ZINC ION, ...
Authors:Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-21
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
J.Inorg.Biochem., 81, 2000
1D1X
  • Download 1d1x
  • View 1d1x
Molmil generated image of 1d1x
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,4-PBITU (H4B BOUND)
Descriptor:BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-21
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
J.Biol.Chem., 276, 2001
1D1Y
  • Download 1d1y
  • View 1d1y
Molmil generated image of 1d1y
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE)
Descriptor:BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-09-21
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
J.Biol.Chem., 276, 2001
1DM6
  • Download 1dm6
  • View 1dm6
Molmil generated image of 1dm6
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N-(4-CHLOROPHENYL)-N'-HYDROXYGUANIDINE (H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-12-13
Release date:2000-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry, 40, 2001
1DM7
  • Download 1dm7
  • View 1dm7
Molmil generated image of 1dm7
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH HOMOARGININE (H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-12-13
Release date:2000-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed With Various Inhibitors
To be Published
1DM8
  • Download 1dm8
  • View 1dm8
Molmil generated image of 1dm8
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:1999-12-13
Release date:2000-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structures of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed With Various Inhibitors
To be Published
1ED4
  • Download 1ed4
  • View 1ed4
Molmil generated image of 1ed4
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH IPITU (H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Kral, V., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-01-26
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.
J.Inorg.Biochem., 81, 2000
1ED5
  • Download 1ed5
  • View 1ed5
Molmil generated image of 1ed5
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH NNA(H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-01-26
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Biochemistry, 40, 2001
1ED6
  • Download 1ed6
  • View 1ed6
Molmil generated image of 1ed6
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-NIO (H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-01-26
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Biochemistry, 40, 2001
1FOI
  • Download 1foi
  • View 1foi
Molmil generated image of 1foi
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1400W(H4B-FREE)
Descriptor:NITRIC-OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-08-28
Release date:2001-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Biochemistry, 40, 2001
1FOJ
  • Download 1foj
  • View 1foj
Molmil generated image of 1foj
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 7-NITROINDAZOLE-2-CARBOXAMIDINE (H4B PRESENT)
Descriptor:NITRIC-OXIDE SYNTHASE, CACODYLATE ION, ACETATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S., Poulos, T.L.
Deposit date:2000-08-28
Release date:2001-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism
Biochemistry, 40, 2001
1FOL
  • Download 1fol
  • View 1fol
Molmil generated image of 1fol
REDUCED BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG(H4B-FREE)
Descriptor:NITRIC-OXIDE SYNTHASE, CACODYLATE ION, ACETATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S., Poulos, T.L.
Deposit date:2000-08-28
Release date:2001-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors
Biochemistry, 40, 2001
1FOO
  • Download 1foo
  • View 1foo
Molmil generated image of 1foo
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-FREE)
Descriptor:NITRIC-OXIDE SYNTHASE, CACODYLATE ION, ACETATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-08-28
Release date:2001-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Biochemistry, 40, 2001
1FOP
  • Download 1fop
  • View 1fop
Molmil generated image of 1fop
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-BOUND)
Descriptor:NITRIC-OXIDE SYNTHASE, CACODYLATE ION, ACETATE ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L.
Deposit date:2000-08-28
Release date:2001-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.
Biochemistry, 40, 2001
1I83
  • Download 1i83
  • View 1i83
Molmil generated image of 1i83
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE (H4B FREE)
Descriptor:NITRIC OXIDE SYNTHASE, ACETATE ION, ZINC ION, ...
Authors:Raman, C.S., Li, H., Martasek, P., Babu, B.R., Griffith, O.W., Masters, B.S.S., Poulos, T.L.
Deposit date:2001-03-12
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
J.Biol.Chem., 276, 2001
1K2R
  • Download 1k2r
  • View 1k2r
Molmil generated image of 1k2r
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH NG-NITRO-L-ARGININE
Descriptor:nitric-oxide synthase, ACETATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2S
  • Download 1k2s
  • View 1k2s
Molmil generated image of 1k2s
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH NG-ALLYL-L-ARGININE
Descriptor:nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2T
  • Download 1k2t
  • View 1k2t
Molmil generated image of 1k2t
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA
Descriptor:nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published
1K2U
  • Download 1k2u
  • View 1k2u
Molmil generated image of 1k2u
STRUCTURE OF RAT BRAIN NNOS HEME DOMAIN COMPLEXED WITH S-ETHYL-N-[4-(TRIFLUOROMETHYL)PHENYL] ISOTHIOUREA
Descriptor:nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Li, H., Martasek, P., Masters, B.S.S., Poulos, T.L., Raman, C.S.
Deposit date:2001-09-28
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of rat brain nNOS heme domain
To be Published