Author results

2K86
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SOLUTION STRUCTURE OF FOXO3A FORKHEAD DOMAIN
Descriptor:Forkhead box protein O3
Authors:Wang, F., Marshall, C.B., Li, G., Plevin, M.J., Ikura, M.
Deposit date:2008-09-02
Release date:2008-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
J.Mol.Biol., 384, 2008
2LQH
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NMR STRUCTURE OF FOXO3A TRANSACTIVATION DOMAINS (CR2C-CR3) IN COMPLEX WITH CBP KIX DOMAIN (2B3L CONFORMATION)
Descriptor:CREB-binding protein, Forkhead box O3
Authors:Wang, F., Marshall, C.B., Yamamoto, K., Li, G.B., Gasmi-Seabrook, G.M.C., Okada, H., Mak, T.W., Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LQI
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NMR STRUCTURE OF FOXO3A TRANSACTIVATION DOMAINS (CR2C-CR3) IN COMPLEX WITH CBP KIX DOMAIN (2L3B CONFORMATION)
Descriptor:CREB-binding protein, Forkhead box O3
Authors:Wang, F., Marshall, C.B., Yamamoto, K., Li, G.B., Gasmi-Seabrook, G.M.C., Okada, H., Mak, T.W., Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SEA
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STRUCTURE OF RHEB-Y35A MUTANT IN GDP- AND GMPPNP-BOUND FORMS
Descriptor:GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mazhab-Jafari, M.T., Marshall, C.B., Ishiyama, N., Vuk, S., Ikura, M.
Deposit date:2011-06-10
Release date:2012-06-20
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis.
Structure, 20, 2012
4O25
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STRUCTURE OF WILD TYPE MUS MUSCULUS RHEB BOUND TO GTP
Descriptor:GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Mazhab-Jafari, M.T., Marshall, C.B., Ho, J., Ishiyama, N., Stambolic, V., Ikura, M.
Deposit date:2013-12-16
Release date:2014-03-26
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
4O2L
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STRUCTURE OF MUS MUSCULUS RHEB G63A MUTANT BOUND TO GTP
Descriptor:GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Mazhab-Jafari, M.T., Marshall, C.B., Ho, J., Ishiyama, N., Stambolic, V., Ikura, M.
Deposit date:2013-12-17
Release date:2014-03-26
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
4O2R
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STRUCTURE OF MUS MUSCULUS RHEB G63V MUTANT BOUND TO GDP
Descriptor:GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Mazhab-Jafari, M.T., Marshall, C.B., Ho, J., Ishiyama, N., Stambolic, V., Ikura, M.
Deposit date:2013-12-17
Release date:2014-03-26
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
J.Biol.Chem., 289, 2014
5WI4
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CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2
Descriptor:Dynein light chain Tctex-type 1,Rho guanine nucleotide exchange factor 2, SULFATE ION
Authors:Balan, M., Ishiyama, N., Marshall, C.B., Ikura, M.
Deposit date:2017-07-18
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
Sci Signal, 10, 2017
6CC9
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GMPPNP:CMPD2 COMPLEX TETHERED TO A NANODISC
Descriptor:Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fang, Z., Marshall, C.B., Nishikawa, T., Gossert, A.D., Jansen, J.M., Jahnke, W., Ikura, M.
Deposit date:2018-02-06
Release date:2018-09-05
Method:SOLUTION NMR
Cite:NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc
To be Published
6CCH
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GMPPNP TETHERED TO A NANODISC (E3 STATE)
Descriptor:Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fang, Z., Marshall, C.B., Nishikawa, T., Gossert, A.D., Jansen, J.M., Jahnke, W., Ikura, M.
Deposit date:2018-02-07
Release date:2018-08-29
Last modified:2018-11-28
Method:SOLUTION NMR
Cite:Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
Cell Chem Biol, 25, 2018
6CCX
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GMPPNP:CMPD2 COMPLEX TETHERED TO A NANODISC
Descriptor:Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Fang, Z., Marshall, C.B., Nishikawa, T., Gossert, A.D., Jansen, J.M., Jahnke, W., Ikura, M.
Deposit date:2018-02-07
Release date:2018-09-05
Method:SOLUTION NMR
Cite:NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc
To be Published
2MSC
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GDP TETHERED TO A LIPID-BILAYER NANODISC
Descriptor:Apolipoprotein A-I, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, ...
Authors:Mazhab-Jafari, M., Stathopoulos, P., Marshall, C., Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
2MSD
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GNP TETHERED TO A LIPID-BILAYER NANODISC
Descriptor:Apolipoprotein A-I, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, ...
Authors:Mazhab-Jafari, M., Stathopoulos, P., Marshall, C., Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
2MSE
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NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GNP:ARAFRBD COMPLEX TETHERED TO A LIPID-BILAYER NANODISC
Descriptor:Apolipoprotein A-I, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, ...
Authors:Mazhab-Jafari, M., Stathopoulos, P., Marshall, C., Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
3ULT
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CRYSTAL STRUCTURE OF AN ICE-BINDING PROTEIN FROM THE PERENNIAL RYEGRASS, LOLIUM PERENNE
Descriptor:Ice recrystallization inhibition protein-like protein, 1,2-ETHANEDIOL, ETHANOL
Authors:Middleton, A.J., Faucher, F., Campbell, R.L., Davies, P.L.
Deposit date:2011-11-11
Release date:2012-02-15
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Antifreeze protein from freeze-tolerant grass has a beta-roll fold with an irregularly structured ice-binding site.
J.Mol.Biol., 416, 2012
4KE2
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CRYSTAL STRUCTURE OF THE HYPERACTIVE TYPE I ANTIFREEZE FROM WINTER FLOUNDER
Descriptor:Type I hyperactive antifreeze protein
Authors:Sun, T., Lin, F.-H., Campbell, R.L., Allingham, J.S., Davies, P.L.
Deposit date:2013-04-25
Release date:2014-02-26
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters.
Science, 343, 2014