Author results

4UYI
  • Download 4uyi
  • View 4uyi
Molmil generated image of 4uyi
CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN SLX4 (BTBD12)
Descriptor:STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4
Authors:Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-09-01
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the Btb Domain of Human Slx4 (Btbd12)
To be Published
6QNV
  • Download 6qnv
  • View 6qnv
Molmil generated image of 6qnv
FIBRINOGEN-LIKE GLOBE DOMAIN OF HUMAN TENASCIN-C
Descriptor:Tenascin
Authors:Coker, J.A., Bezerra, G.A., Bradshaw, W.J., Zhang, M., Yosaatmadja, Y., Fernandez-Cid, A., Shrestha, L., Burgess-Brown, N., Gileadi, O., Arrowsmith, C.H., Bountra, C., Midwood, K.S., Yue, W.W., Marsden, B.D., Structural Genomics Consortium (SGC)
Deposit date:2019-02-12
Release date:2019-02-27
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fibrinogen-like globe domain of Human Tenascin-C
To Be Published
2CLP
  • Download 2clp
  • View 2clp
Molmil generated image of 2clp
CRYSTAL STRUCTURE OF HUMAN AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3
Descriptor:AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
Authors:Debreczeni, J.E., Marsden, B.D., Johansson, C., Kavanagh, K., Guo, K., Smee, C., Gileadi, O., Turnbull, A., Papagrigoriou, E., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Oppermann, U.
Deposit date:2006-04-28
Release date:2006-05-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
To be Published
2VPJ
  • Download 2vpj
  • View 2vpj
Molmil generated image of 2vpj
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL12
Descriptor:KELCH-LIKE PROTEIN 12, ACETATE ION
Authors:Keates, T., Pike, A.C.W., Bullock, A.N., Salah, E., Filippakopoulos, P., Roos, A.K., von Delft, F., Savitsky, P., Weigelt, J., Edwards, A., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2XN4
  • Download 2xn4
  • View 2xn4
Molmil generated image of 2xn4
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL2 (MAYVEN)
Descriptor:KELCH-LIKE PROTEIN 2, SODIUM ION, SULFATE ION, ...
Authors:Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2010-07-30
Release date:2010-08-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2YGW
  • Download 2ygw
  • View 2ygw
Molmil generated image of 2ygw
CRYSTAL STRUCTURE OF HUMAN MCD
Descriptor:MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL, UNKNOWN ATOM OR ION, ...
Authors:Vollmar, M., Puranik, S., Krojer, T., Savitsky, P., Allerston, C., Yue, W.W., Chaikuad, A., von Delft, F., Gileadi, O., Kavanagh, K., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-04-21
Release date:2012-02-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations.
Structure, 21, 2013
3GGF
  • Download 3ggf
  • View 3ggf
Molmil generated image of 3ggf
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE MST4 IN COMPLEX WITH AN QUINAZOLIN
Descriptor:Serine/threonine-protein kinase MST4, CADMIUM ION, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE
Authors:Chaikuad, A., Rellos, P., Eidarus, S., Das, S., Pike, A.C.W., Sethi, R., Fedorov, O., Savitsky, P., Roos, A.K., Filippakopoulos, P., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural comparison of human mammalian ste20-like kinases
Plos One, 5, 2010
3II7
  • Download 3ii7
  • View 3ii7
Molmil generated image of 3ii7
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL7
Descriptor:Kelch-like protein 7, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Thangaratnarajah, C., Cooper, C.D.O., Ugochukwu, E., Muniz, J.R.C., Krojer, T., Sethi, R., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-08-25
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
J.Biol.Chem., 288, 2013
3U4S
  • Download 3u4s
  • View 3u4s
Molmil generated image of 3u4s
HISTONE LYSINE DEMETHYLASE JMJD2A IN COMPLEX WITH T11C PEPTIDE SUBSTRATE CROSSLINKED TO N-OXALYL-D-CYSTEINE
Descriptor:Lysine-specific demethylase 4A, HISTONE 3 TAIL ANALOG (T11C Peptide), NICKEL (II) ION, ...
Authors:Ma, J., McDonough, M.A., Schofield, C.J.
Deposit date:2011-10-10
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Angew.Chem.Int.Ed.Engl., 51, 2012
3ZDQ
  • Download 3zdq
  • View 3zdq
Molmil generated image of 3zdq
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (NUCLEOTIDE-FREE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL, GLYCINE, ...
Authors:Pike, A.C.W., Shintre, C.A., Krojer, T., von Delft, F., Vollmar, M., Mukhopadhyay, S., Burgess-Brown, N., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-11-30
Release date:2013-01-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AP2
  • Download 4ap2
  • View 4ap2
Molmil generated image of 4ap2
CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 2.8A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN-3, 1,2-ETHANEDIOL, ...
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Filippakopoulos, P., Ayinampudi, V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-03-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4APF
  • Download 4apf
  • View 4apf
Molmil generated image of 4apf
CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 3.1A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN 3
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Vollmar, M., Ugochukwu, E., Muniz, J.R.C., Ayinampudi, V., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-02
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4ASC
  • Download 4asc
  • View 4asc
Molmil generated image of 4asc
CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KBTBD5
Descriptor:KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5, 1,2-ETHANEDIOL
Authors:Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4AYT
  • Download 4ayt
  • View 4ayt
Molmil generated image of 4ayt
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYW
  • Download 4ayw
  • View 4ayw
Molmil generated image of 4ayw
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYX
  • Download 4ayx
  • View 4ayx
Molmil generated image of 4ayx
STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4KS9
  • Download 4ks9
  • View 4ks9
Molmil generated image of 4ks9
CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE (RMET_2797) FROM CUPRIAVIDUS METALLIDURANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CRR76
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Tran, T.H., Lew, S., Seetharaman, J., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KSA
  • Download 4ksa
  • View 4ksa
Molmil generated image of 4ksa
CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM RHODOPSEUDOMONAS PALUSTRIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RPR127
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Patel, D.J., Ciccosanti, C., Wang, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KSF
  • Download 4ksf
  • View 4ksf
Molmil generated image of 4ksf
CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM AGROBACTERIUM VITIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RIR35
Descriptor:Malonyl-CoA decarboxylase, NICKEL (II) ION, CHLORIDE ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Ciccosanti, C., Lee, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
5ENB
  • Download 5enb
  • View 5enb
Molmil generated image of 5enb
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH O-TOLYLTHIOUREA (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 1-(2-methylphenyl)thiourea, 1,2-ETHANEDIOL
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Szykowska, A., Burgess-Brown, N., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENC
  • Download 5enc
  • View 5enc
Molmil generated image of 5enc
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH N-(2,6-DICHLOROBENZYL)ACETAMIDE (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 1,2-ETHANEDIOL, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]ethanamide
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Szykowska, A., Burgess-Brown, N., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENE
  • Download 5ene
  • View 5ene
Molmil generated image of 5ene
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH 5-AMINO-2-BENZYL-1,3-OXAZOLE-4-CARBONITRILE (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 5-azanyl-2-(phenylmethyl)-1,3-oxazole-4-carbonitrile
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Amin, J., Szykowska, A., Burgess-Brown, N., Spencer, J., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENF
  • Download 5enf
  • View 5enf
Molmil generated image of 5enf
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH FRAGMENT-4 N10142 (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, 1,2-ETHANEDIOL, 5-azanyl-2-(2-methylpropyl)-1,3-oxazole-4-carbonitrile
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Amin, J., Szykowska, A., Burgess-Brown, N., Spencer, J., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENH
  • Download 5enh
  • View 5enh
Molmil generated image of 5enh
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH COMPOUND-12 N11528 (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, ~{N}-[(2,6-dimethoxyphenyl)methyl]ethanamide
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Szykowska, A., Burgess-Brown, N., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016
5ENI
  • Download 5eni
  • View 5eni
Molmil generated image of 5eni
CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP) IN COMPLEX WITH COMPOUND-13 N11537 (SGC - DIAMOND I04-1 FRAGMENT SCREENING)
Descriptor:PH-interacting protein, ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanyl-ethanamide
Authors:Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Szykowska, A., Burgess-Brown, N., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2015-11-09
Release date:2016-04-27
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Chem Sci, 7, 2016