Author results

2CLS
  • Download 2cls
  • View 2cls
Molmil generated image of 2cls
THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE
分子名称:RHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Pike, A.C.W., Yang, X., Colebrook, S., Gileadi, O., Sobott, F., Bray, J., Wen Hwa, L., Marsden, B., Zhao, Y., Schoch, G., Elkins, J., Debreczeni, J.E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
登録日2006-04-28
公開日2006-05-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
2NZJ
  • Download 2nzj
  • View 2nzj
Molmil generated image of 2nzj
THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDP
分子名称:GTP-binding protein REM 1, MAGNESIUM ION, CHLORIDE ION, ...
著者Turnbull, A.P., Papagrigoriou, E., Ugochukwu, E., Elkins, J.M., Soundararajan, M., Yang, X., Gorrec, F., Umeano, C., Salah, E., Burgess, N., Johansson, C., Berridge, G., Gileadi, O., Bray, J., Marsden, B., Watts, S., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-11-23
公開日2006-12-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of REM1 in complex with GDP
To be Published
2BEL
  • Download 2bel
  • View 2bel
Molmil generated image of 2bel
STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE
分子名称:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CARBENOXOLONE, ...
著者Kavanagh, K., Wu, X., Svensson, S., Elleby, B., von Delft, F., Debreczeni, J.E., Sharma, S., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Abrahmsen, L., Oppermann, U.
登録日2004-11-25
公開日2004-12-06
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture
To be Published
1ZV4
  • Download 1zv4
  • View 1zv4
Molmil generated image of 1zv4
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 17 (RGSZ2)
分子名称:Regulator of G-protein signaling 17
著者Schoch, G.A., Jansson, A., Elkins, J.M., Haroniti, A., Niesen, F.H., Bunkoczi, G., Lee, W.H., Turnbull, A.P., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Marsden, B., Gileadi, O., Ball, L., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2005-06-01
公開日2005-06-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2A8B
  • Download 2a8b
  • View 2a8b
Molmil generated image of 2a8b
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE PHOSPHATASE RECEPTOR, TYPE R
分子名称:Receptor-type tyrosine-protein phosphatase R, CHLORIDE ION
著者Ugochukwu, E., Eswaran, J., Barr, A., Longman, E., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
登録日2005-07-07
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem.J., 395, 2006
2BIJ
  • Download 2bij
  • View 2bij
Molmil generated image of 2bij
CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE)
分子名称:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION
著者Barr, A.J., Debreczeni, J.E., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S., von Delft, F.
登録日2005-01-21
公開日2005-03-17
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2BV5
  • Download 2bv5
  • View 2bv5
Molmil generated image of 2bv5
CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION
分子名称:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION, ...
著者Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-06-22
公開日2005-07-14
最終更新日2019-10-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2J2I
  • Download 2j2i
  • View 2j2i
Molmil generated image of 2j2i
CRYSTAL STRUCTURE OF THE HUMAB PIM1 IN COMPLEX WITH LY333531
分子名称:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION, (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE
著者Debreczeni, J.E., Bullock, A.N., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S.
登録日2006-08-16
公開日2007-02-13
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U.S.A., 104, 2007
4AI8
  • Download 4ai8
  • View 4ai8
Molmil generated image of 4ai8
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE
分子名称:HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, SULFATE ION, GLYCEROL, ...
著者King, O.N.F., Chowdhury, R., Rose, N.R., McDonough, M.A., Clifton, I.J., Schofield, C.J., Kawamura, A.
登録日2012-02-08
公開日2012-10-03
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4AI9
  • Download 4ai9
  • View 4ai9
Molmil generated image of 4ai9
JMJD2A COMPLEXED WITH DAMINOZIDE
分子名称:LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, ZINC ION, ...
著者Chowdhury, R., Schofield, C.J.
登録日2012-02-08
公開日2012-10-03
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J. Med. Chem., 55, 2012
4E96
  • Download 4e96
  • View 4e96
Molmil generated image of 4e96
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH THE INHIBITOR PFI-1
分子名称:Bromodomain-containing protein 4, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide, SODIUM ION, ...
著者Filippakopoulos, P., Picaud, S., Felletar, I., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Fish, P., Bunnage, M., Owen, D., Knapp, S., Cook, A., Structural Genomics Consortium (SGC)
登録日2012-03-20
公開日2012-04-18
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.
J.Med.Chem., 55, 2012
4HBV
  • Download 4hbv
  • View 4hbv
Molmil generated image of 4hbv
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A QUINAZOLIN LIGAND
分子名称:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one
著者Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)
登録日2012-09-28
公開日2012-10-31
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012
4HBW
  • Download 4hbw
  • View 4hbw
Molmil generated image of 4hbw
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A QUINAZOLINE LIGAND
分子名称:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-ethyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, ...
著者Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)
登録日2012-09-28
公開日2012-10-31
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012
4HBX
  • Download 4hbx
  • View 4hbx
Molmil generated image of 4hbx
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A QUINAZOLIN LIGAND
分子名称:Bromodomain-containing protein 4, 3-methyl-6-(pyrrolidin-1-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one
著者Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)
登録日2012-09-28
公開日2012-10-31
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012
4HBY
  • Download 4hby
  • View 4hby
Molmil generated image of 4hby
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A QUINAZOLIN LIGAND
分子名称:Bromodomain-containing protein 4, 3-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, 1,2-ETHANEDIOL
著者Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Fish, P.V., Bunnage, M.E., Cook, A.S., Owen, D.R., Knapp, S., Structural Genomics Consortium (SGC)
登録日2012-09-28
公開日2012-10-31
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012