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3NZJ
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2A
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-16
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH 2B
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-17
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2C
分子名称:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
著者Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
登録日2010-07-17
公開日2011-02-16
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
4JSQ
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:4E
分子名称:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
著者Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
登録日2013-03-22
公開日2013-05-01
最終更新日2014-04-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
J.Med.Chem., 56, 2013
4JSU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:3A
分子名称:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
著者Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
登録日2013-03-22
公開日2013-05-01
最終更新日2014-04-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome
J.Med.Chem., 56, 2013
4JT0
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YEAST 20S PROTEASOME IN COMPLEX WITH THE DIMERIZED LINEAR MIMETIC OF TMC-95A - YCP:4A
分子名称:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
著者Desvergne, A., Genin, E., Marechal, X., Gallastegui, N., Dufau, L., Richy, N., Groll, M., Vidal, J., Reboud-Ravaux, M.
登録日2013-03-22
公開日2013-05-01
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Dimerized Linear Mimics of a Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome
J.Med.Chem., 2013
4GSF
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THE STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]-ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER
分子名称:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate, ZINC ION
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
4QIA
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INHIBITOR N-BENZYL-N-(CARBOXYMETHYL)GLYCYL-L-HISTIDINE
分子名称:Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2014-05-30
公開日2015-05-13
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
2YPU
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HUMAN INSULIN DEGRADING ENZYME E111Q IN COMPLEX WITH INHIBITOR COMPOUND 41367
分子名称:INSULIN-DEGRADING ENZYME, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.-J.
登録日2012-11-01
公開日2012-11-28
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C, 2014
3QZ2
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THE STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN DEGRADING ENZYME
分子名称:Insulin-degrading enzyme, ZINC ION
著者Guo, Q., Tang, W.J.
登録日2011-03-04
公開日2012-01-25
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DTT
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPUND 41367
分子名称:Insulin-degrading enzyme, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2012-02-21
公開日2013-02-27
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DWK
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STRUCTURE OF CYSTEIN FREE INSULIN DEGRADING ENZYME WITH COMPOUND BDM41671 ((S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPYL)-AMINO]-ACETYLAMINO}-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
分子名称:Insulin-degrading enzyme, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate, ZINC ION
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2012-02-24
公開日2013-04-03
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GS8
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STRUCTURE ANALYSIS OF CYSTEINE FREE INSULIN DEGRADING ENZYME (IDE) WITH COMPOUND BDM43079 [{[(S)-2-(1H-IMIDAZOL-4-YL)-1-METHYLCARBAMOYL-ETHYLCARBAMOYL]-METHYL}-(3-PHENYL-PROPYL)-AMINO]-ACETIC ACID
分子名称:Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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STRUCTURE ANALYSIS OF INSULIN DEGRADING ENZYME WITH COMPOUND BDM41559 ((S)-2-[2-(CARBOXYMETHYL-PHENETHYL-AMINO)-ACETYLAMINO]-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER)
分子名称:Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
著者Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4IFH
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND BDM44619
分子名称:Insulin-degrading enzyme, ZINC ION, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide
著者Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
登録日2012-12-14
公開日2013-12-18
最終更新日2015-10-28
実験手法X-RAY DIFFRACTION (3.286 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4NXO
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH BDM44768
分子名称:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, ...
著者Liang, W.G., Deprez, R., Deprez, B., Tang, W.
登録日2013-12-09
公開日2015-10-07
最終更新日2015-10-28
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4RE9
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND 71290
分子名称:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ...
著者Liang, W.G., Deprez, R., Deprez, B., Tang, W.J.
登録日2014-09-22
公開日2015-09-30
最終更新日2015-10-28
実験手法X-RAY DIFFRACTION (2.908 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015