Author results

1UNG
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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.
Descriptor:CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Authors:Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
1UNH
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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.
Descriptor:CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME
Authors:Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
1UNL
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STRUCTURAL MECHANISM FOR THE INHIBITION OF CD5-P25 FROM THE ROSCOVITINE, ALOISINE AND INDIRUBIN.
Descriptor:CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, R-ROSCOVITINE
Authors:Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
2V64
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CRYSTALLOGRAPHIC STRUCTURE OF THE CONFORMATIONAL DIMER OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2.
Descriptor:MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A, MBP1
Authors:Mapelli, M., Massimiliano, L., Santaguida, S., Musacchio, A.
Deposit date:2007-07-13
Release date:2007-11-27
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
Cell(Cambridge,Mass.), 131, 2007
5NJJ
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PTB DOMAIN OF HUMAN NUMB ISOFORM-1
Descriptor:Protein numb homolog, ALA-TYR-ILE-GLY-PRO-PTR-LEU, SULFATE ION
Authors:Mapelli, M., Di Fiore, P.P.
Deposit date:2017-03-29
Release date:2017-12-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
J. Cell Biol., 217, 2018
5NJK
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PTB DOMAIN OF HUMAN NUMB ISOFORM-1
Descriptor:Protein numb homolog, ALA-TYR-ILE-GLY-PRO-PTR-LEU, SULFATE ION
Authors:Mapelli, M., Di Fiore, P.P.
Deposit date:2017-03-29
Release date:2017-12-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
J. Cell Biol., 217, 2018
1URJ
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SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1
Descriptor:MAJOR DNA-BINDING PROTEIN, ZINC ION, MERCURY (II) ION
Authors:Panjikar, S., Mapelli, M., Tucker, P.A.
Deposit date:2003-10-30
Release date:2004-11-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding.
J. Biol. Chem., 280, 2005
3O0G
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CRYSTAL STRUCTURE OF CDK5:P25 IN COMPLEX WITH AN ATP ANALOGUE
Descriptor:Cell division protein kinase 5, Cyclin-dependent kinase 5 activator 1, {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone
Authors:Mapelli, M.
Deposit date:2010-07-19
Release date:2011-01-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Defining Cdk5 ligand chemical space with small molecule inhibitors of Tau phosphorylation
Chem.Biol., 12, 2005
4A7J
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SYMMETRIC DIMETHYLATION OF H3 ARGININE 2 IS A NOVEL HISTONE MARK THAT SUPPORTS EUCHROMATIN MAINTENANCE
Descriptor:WD REPEAT-CONTAINING PROTEIN 5, HISTONE H3.1T
Authors:Migliori, V., Muller, J., Phalke, S., Low, D., Bezzi, M., ChuenMok, W., Gunaratne, J., Capasso, P., Bassi, C., Cecatiello, V., DeMarco, A., Blackstock, W., Kuznetsov, V., Amati, B., Mapelli, M., Guccione, E.
Deposit date:2011-11-14
Release date:2012-01-11
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance
Nat.Struct.Mol.Biol., 19, 2012
5A6C
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CONCOMITANT BINDING OF AFADIN TO LGN AND F-ACTIN DIRECTS PLANAR SPINDLE ORIENTATION
Descriptor:G-PROTEIN-SIGNALING MODULATOR 2, AFADIN, SULFATE ION
Authors:Carminati, M., Gallini, S., Pirovano, L., Alfieri, A., Bisi, S., Mapelli, M.
Deposit date:2015-06-25
Release date:2015-12-30
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Concomitant Binding of Afadin to Lgn and F-Actin Directs Planar Spindle Orientation.
Nat.Struct.Mol.Biol., 23, 2016
5A7D
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TETRAMERIC ASSEMBLY OF LGN WITH INSCUTEABLE
Descriptor:PINS, INSCUTEABLE
Authors:Culurgioni, S., Mari, S., Bonetto, G., Gallini, S., Brennich, M., Round, A., Mapelli, M.
Deposit date:2015-07-07
Release date:2016-08-03
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Structure of the Insc:Lgn Tetramer Reveals a New Function of Lgn in Promoting Asymmetric Cell Divisions
To be Published
1GO4
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CRYSTAL STRUCTURE OF MAD1-MAD2 REVEALS A CONSERVED MAD2 BINDING MOTIF IN MAD1 AND CDC20.
Descriptor:Mitotic spindle assembly checkpoint protein MAD2A, Mitotic spindle assembly checkpoint protein MAD1
Authors:Sironi, L., Mapelli, M., Jeang, K.T., Musacchio, A.
Deposit date:2001-10-17
Release date:2002-05-16
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
EMBO J., 21, 2002
2BFX
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MECHANISM OF AURORA-B ACTIVATION BY INCENP AND INHIBITION BY HESPERADIN.
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2BFY
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COMPLEX OF AURORA-B WITH INCENP AND HESPERADIN.
Descriptor:AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE
Authors:Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T., Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2C7M
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HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN
Descriptor:RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION
Authors:Penengo, L., Mapelli, M., Murachelli, A.G., Confalioneri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S., Schneider, T.R.
Deposit date:2005-11-25
Release date:2006-02-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
Cell, 124, 2006
2C7N
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HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN
Descriptor:RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION
Authors:Penengo, L., Mapelli, M., Murachelli, A.G., Confalioneri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S., Schneider, T.R.
Deposit date:2005-11-25
Release date:2006-02-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
4A1S
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CRYSTALLOGRAPHIC STRUCTURE OF THE PINS:INSC COMPLEX
Descriptor:PARTNER OF INSCUTEABLE, RE60102P
Authors:Culurgioni, S., Alfieri, A., Pendolino, V., Laddomada, F., Mapelli, M.
Deposit date:2011-09-19
Release date:2012-03-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inscuteable and Numa Proteins Bind Competitively to Leu-Gly- Asn Repeat-Enriched Protein (Lgn) During Asymmetric Cell Divisions.
Proc.Natl.Acad.Sci.USA, 108, 2011
6HC2
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CRYSTAL STRUCTURE OF NUMA/LGN HETERO-HEXAMERS
Descriptor:G-protein-signaling modulator 2, Nuclear mitotic apparatus protein 1
Authors:Pasqualato, S., Culurgioni, S., Foadi, J., Alfieri, A., Mapelli, M.
Deposit date:2018-08-13
Release date:2019-05-29
Method:X-RAY DIFFRACTION (4.31 Å)
Cite:Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Nat Commun, 10, 2019
2N12
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SOLUTION STRUCTURE OF HUMAN MYOSIN VI ISOFORM3 (1050-1131)
Descriptor:Unconventional myosin-VI
Authors:He, F., Walters, K.
Deposit date:2015-03-20
Release date:2016-03-02
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Diverse functions of myosin VI elucidated by an isoform-specific alpha-helix domain.
Nat.Struct.Mol.Biol., 23, 2016