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3GZF
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STRUCTURE OF THE C-TERMINAL DOMAIN OF NSP4 FROM FELINE CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, SULFATE ION
Authors:Manolaridis, I., Wojdyla, J.A., Panjikar, S., Snijder, E.J., Gorbalenya, A.E., Coutard, B., Tucker, P.A.
Deposit date:2009-04-07
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structure of the C-terminal domain of nsp4 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
6HBU
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CRYO-EM STRUCTURE OF THE ABCG2 E211Q MUTANT BOUND TO ATP AND MAGNESIUM
Descriptor:ATP-binding cassette sub-family G member 2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P.
Deposit date:2018-08-13
Release date:2018-11-07
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HCO
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CRYO-EM STRUCTURE OF THE ABCG2 E211Q MUTANT BOUND TO ESTRONE 3-SULFATE AND 5D3-FAB
Descriptor:ATP-binding cassette sub-family G member 2, 5D3-Fab light chain, 5D3-Fab heavy chain, ...
Authors:Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P.
Deposit date:2018-08-15
Release date:2018-11-07
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HZM
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CRYO-EM STRUCTURE OF THE ABCG2 E211Q MUTANT BOUND TO ATP AND MAGNESIUM (ALTERNATIVE PLACEMENT OF MAGNESIUM INTO THE CRYO-EM DENSITY)
Descriptor:ATP-binding cassette sub-family G member 2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P.
Deposit date:2018-10-23
Release date:2018-11-14
Last modified:2018-11-28
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
2L8K
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NMR STRUCTURE OF THE ARTERIVIRUS NONSTRUCTURAL PROTEIN 7 ALPHA (NSP7 ALPHA)
Descriptor:Non-structural protein 7
Authors:Conte, M.R., Gaudin, C., Manolaridis, I., Tucker, P.W., Kelly, G.
Deposit date:2011-01-19
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
4CAD
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MECHANISM OF FARNESYLATED CAAX PROTEIN PROCESSING BY THE INTEGRAL MEMBRANE PROTEASE RCE1
Descriptor:ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, RAS AND A-FACTOR CONVERTING ENZYME 1, ...
Authors:Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D.
Deposit date:2013-10-08
Release date:2013-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
5NIV
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CRYSTAL STRUCTURE OF 5D3 FAB
Descriptor:Light chain of 5D3 Fab, Heavy chain of 5D3 Fab
Authors:Manolaridis, I., Locher, K.P.
Deposit date:2017-03-27
Release date:2017-06-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
1OWX
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SOLUTION STRUCTURE OF THE C-TERMINAL RRM OF HUMAN LA (LA225-334)
Descriptor:Lupus La protein
Authors:Jacks, A., Babon, J., Kelly, G., Manolaridis, I., Cary, P.D., Curry, S., Conte, M.R.
Deposit date:2003-03-31
Release date:2003-07-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
Structure, 11, 2003
3ETI
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STRUCTURE OF A CUBIC CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV
Descriptor:macro domain of Non-structural protein 3
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2008-10-08
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3EW5
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STRUCTURE OF THE TETRAGONAL CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV
Descriptor:macro domain of Non-structural protein 3, CHLORIDE ION, SULFATE ION, ...
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2008-10-14
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3JZT
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STRUCTURE OF A CUBIC CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV WITH ADP-RIBOSE
Descriptor:macro domain of Non-structural protein 3, CHLORIDE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2009-09-24
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3MP2
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CRYSTAL STRUCTURE OF TRANSMISSIBLE GASTROENTERITIS VIRUS PAPAIN-LIKE PROTEASE 1
Descriptor:Non-structural protein 3, ZINC ION
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2010-04-24
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates.
J.Virol., 84, 2010
4A2N
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CRYSTAL STRUCTURE OF MA-ICMT
Descriptor:ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, PALMITIC ACID, ...
Authors:Yang, J., Kulkarni, K., Manolaridis, I., Zhang, Z., Dodd, R.B., Mas-Droux, C., Barford, D.
Deposit date:2011-09-27
Release date:2012-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
5NJ3
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STRUCTURE OF AN ABC TRANSPORTER: COMPLETE STRUCTURE
Descriptor:ATP-binding cassette sub-family G member 2, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
5NJG
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STRUCTURE OF AN ABC TRANSPORTER: PART OF THE STRUCTURE THAT COULD BE BUILT DE NOVO
Descriptor:ATP-binding cassette sub-family G member 2, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
6ETI
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STRUCTURE OF INHIBITOR-BOUND ABCG2
Descriptor:ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ...
Authors:Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P.
Deposit date:2017-10-26
Release date:2018-04-11
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FEQ
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STRUCTURE OF INHIBITOR-BOUND ABCG2
Descriptor:ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ...
Authors:Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P.
Deposit date:2018-01-03
Release date:2018-04-11
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FFC
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STRUCTURE OF AN INHIBITOR-BOUND ABC TRANSPORTER
Descriptor:ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Authors:Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N.M.I., Bause, M., Bauer, S., Bartholomaeus, R., Stahlberg, H., Bernhardt, G., Koenig, B., Buschauer, A., Altmann, K.H., Locher, K.P.
Deposit date:2018-01-06
Release date:2018-04-11
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6HIJ
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CRYO-EM STRUCTURE OF THE HUMAN ABCG2-MZ29-FAB COMPLEX WITH CHOLESTEROL AND PE LIPIDS DOCKED
Descriptor:ATP-binding cassette sub-family G member 2, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ...
Authors:Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N.M.I., Bause, M., Bauer, S., Bartholomaeus, R., Stahlberg, H., Bernhardt, G., Koenig, B., Buschauer, A., Altmann, K.H., Locher, K.P.
Deposit date:2018-08-30
Release date:2018-09-19
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat.Struct.Mol.Biol., 25, 2018