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3GZF
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BU of 3gzf by Molmil
Structure of the C-terminal domain of nsp4 from Feline Coronavirus
Descriptor: Replicase polyprotein 1ab, SULFATE ION
Authors:Manolaridis, I, Wojdyla, J.A, Panjikar, S, Snijder, E.J, Gorbalenya, A.E, Coutard, B, Tucker, P.A.
Deposit date:2009-04-07
Release date:2009-08-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structure of the C-terminal domain of nsp4 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
6HZM
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BU of 6hzm by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium (alternative placement of Magnesium into the cryo-EM density)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-10-23
Release date:2018-11-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HBU
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BU of 6hbu by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family G member 2, MAGNESIUM ION
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-08-13
Release date:2018-11-07
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
6HCO
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BU of 6hco by Molmil
Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Manolaridis, I, Jackson, S.M, Taylor, N.M.I, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2018-08-15
Release date:2018-11-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.
Nature, 563, 2018
2L8K
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BU of 2l8k by Molmil
NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha)
Descriptor: Non-structural protein 7
Authors:Conte, M.R, Gaudin, C, Manolaridis, I, Tucker, P.W, Kelly, G.
Deposit date:2011-01-19
Release date:2011-07-06
Last modified:2023-02-08
Method:SOLUTION NMR
Cite:Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
4CAD
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BU of 4cad by Molmil
Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Kulkarni, K, Manolaridis, I, Dodd, R.B, Cronin, N, Ogasawara, S, Iwata, S, Barford, D.
Deposit date:2013-10-08
Release date:2013-11-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
5NIV
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BU of 5niv by Molmil
Crystal structure of 5D3 Fab
Descriptor: Heavy chain of 5D3 Fab, Light chain of 5D3 Fab
Authors:Manolaridis, I, Locher, K.P.
Deposit date:2017-03-27
Release date:2017-06-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
3MP2
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BU of 3mp2 by Molmil
Crystal structure of transmissible gastroenteritis virus papain-like protease 1
Descriptor: Non-structural protein 3, ZINC ION
Authors:Wojdyla, J.A, Manolaridis, I, Tucker, P.A.
Deposit date:2010-04-24
Release date:2010-09-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates.
J.Virol., 84, 2010
1OWX
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BU of 1owx by Molmil
Solution structure of the C-terminal RRM of human La (La225-334)
Descriptor: Lupus La protein
Authors:Jacks, A, Babon, J, Kelly, G, Manolaridis, I, Cary, P.D, Curry, S, Conte, M.R.
Deposit date:2003-03-31
Release date:2003-07-29
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
Structure, 11, 2003
8P8A
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BU of 8p8a by Molmil
Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
Deposit date:2023-05-31
Release date:2023-08-30
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
8P7W
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BU of 8p7w by Molmil
Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2
Descriptor: 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ATP-binding cassette sub-family G member 2, ...
Authors:Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
Deposit date:2023-05-31
Release date:2023-08-30
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
8P8J
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BU of 8p8j by Molmil
Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
Deposit date:2023-06-01
Release date:2023-08-30
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
3JZT
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BU of 3jzt by Molmil
Structure of a cubic crystal form of X (ADRP) domain from FCoV with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, SODIUM ION, ...
Authors:Wojdyla, J.A, Manolaridis, I, Tucker, P.A.
Deposit date:2009-09-24
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3ETI
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BU of 3eti by Molmil
Structure of a cubic crystal form of X (ADRP) domain from FCoV
Descriptor: macro domain of Non-structural protein 3
Authors:Wojdyla, J.A, Manolaridis, I, Tucker, P.A.
Deposit date:2008-10-08
Release date:2009-10-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3EW5
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BU of 3ew5 by Molmil
Structure of the tetragonal crystal form of X (ADRP) domain from FCoV
Descriptor: CHLORIDE ION, SN-GLYCEROL-1-PHOSPHATE, SULFATE ION, ...
Authors:Wojdyla, J.A, Manolaridis, I, Tucker, P.A.
Deposit date:2008-10-14
Release date:2009-10-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
4A2N
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BU of 4a2n by Molmil
Crystal Structure of Ma-ICMT
Descriptor: CARDIOLIPIN, ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, PALMITIC ACID, ...
Authors:Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, R.B, Mas-Droux, C, Barford, D.
Deposit date:2011-09-27
Release date:2012-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
6ETI
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BU of 6eti by Molmil
Structure of inhibitor-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P.
Deposit date:2017-10-26
Release date:2018-04-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FFC
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BU of 6ffc by Molmil
Structure of an inhibitor-bound ABC transporter
Descriptor: ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P.
Deposit date:2018-01-06
Release date:2018-04-11
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
6FEQ
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BU of 6feq by Molmil
Structure of inhibitor-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P.
Deposit date:2018-01-03
Release date:2018-04-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
7OJ8
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BU of 7oj8 by Molmil
ABCG2 E1S turnover-2 state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ...
Authors:Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-14
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJI
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BU of 7oji by Molmil
ABCG2 topotecan turnover-2 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-16
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJH
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BU of 7ojh by Molmil
ABCG2 topotecan turnover-1 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-15
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
5NJG
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BU of 5njg by Molmil
Structure of an ABC transporter: part of the structure that could be built de novo
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
5NJ3
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BU of 5nj3 by Molmil
Structure of an ABC transporter: complete structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
6HIJ
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BU of 6hij by Molmil
Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked
Descriptor: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P.
Deposit date:2018-08-30
Release date:2018-09-19
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat.Struct.Mol.Biol., 25, 2018

 

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