Author results

3J5L
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STRUCTURE OF THE E. COLI 50S SUBUNIT WITH ERMBL NASCENT CHAIN
Descriptor:50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, ...
Authors:Arenz, S., Ramu, H., Gupta, P., Berninghausen, O., Beckmann, R., Vazquez-Laslop, N., Mankin, A.S., Wilson, D.N.
Deposit date:2013-10-23
Release date:2014-03-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.
Nat Commun, 5, 2014
4V7S
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO TELITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2547 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7T
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CHLORAMPHENICOL.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-14
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1942 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7U
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO ERYTHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-15
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7V
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CLINDAMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2891 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2I
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, N., Mankin, A.S.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
4WWW
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CEM-101
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Dunkle, J.A., Zhang, W., Cate, J.H.D., Mankin, A.S.
Deposit date:2014-11-12
Release date:2014-12-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Antimicrob. Agents Chemother., 54, 2010
5HAU
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE BAC7(1-19) BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2015-12-30
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCP
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE METALNIKOWIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCQ
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN D15-19 BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCR
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN 10WT BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HD1
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE PYRRHOCORICIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5WIS
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
Descriptor:23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
5WIT
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
6CAE
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NOSO-95179 ANTIBIOTIC AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Pantel, L., Florin, T., Dobosz-Bartoszek, M., Racine, E., Sarciaux, M., Serri, M., Houard, J., Campagne, J.M., Marcia de Figueiredo, R., Midrier, C., Gaudriault, S., Givaudan, A., Lanois, A., Forst, S., Aumelas, A., Cotteaux-Lautard, C., Bolla, J.M., Vingsbo Lundberg, C., Huseby, D., Hughes, D., Villain-Guillot, P., Mankin, A.S., Polikanov, Y.S., Gualtieri, M.
Deposit date:2018-01-30
Release date:2018-04-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol. Cell, 70, 2018
6CFJ
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HISTIDYL-CAM AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
6CFK
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH D-HISTIDYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
6CFL
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH LYSYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
3JQ4
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THE STRUCTURE OF THE COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM D. RADIODURANS WITH THE ANTIBIOTIC LANKACIDIN
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide
Authors:Auerbach-Nevo, T., Mermershtain, I., Davidovich, C., Bashan, A., Rozenberg, H., Yonath, A.
Deposit date:2009-09-06
Release date:2010-09-08
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
Proc.Natl.Acad.Sci.USA, 107, 2010
5O2R
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CRYO-EM STRUCTURE OF THE PROLINE-RICH ANTIMICROBIAL PEPTIDE API137 BOUND TO THE TERMINATING RIBOSOME
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Graf, M., Berninghausen, O., Beckmann, R., Wilson, D.N.
Deposit date:2017-05-22
Release date:2017-07-26
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Nat. Struct. Mol. Biol., 24, 2017
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