7V8J
 
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7V9D
 | | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine | | Descriptor: | (2S)-azetidine-2-carboxylic acid, 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, ... | | Authors: | Manickam, Y, Malhotra, N, Sharma, A. | | Deposit date: | 2021-08-24 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.937 Å) | | Cite: | Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine
To Be Published
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7V8K
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7X1O
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7X09
 | | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone | | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ... | | Authors: | Manickam, Y, Babbar, P, Pillai, P, Sharma, A. | | Deposit date: | 2022-02-21 | | Release date: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95)
To Be Published
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7DIU
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7DIQ
 | | Structure of PfGrx1 with zinc | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIN
 | | Structure of PfGrx1 with cobalt | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, COBALT (II) ION, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIL
 | | Structure of PfGrx1 with cesium | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CESIUM ION, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIK
 | | Structure of PfGrx1 with barium | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, BARIUM ION, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIO
 | | Structure of PfGrx1 with iron | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE (III) ION, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.899 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIS
 | | Structure of the PfGrx1 with platinum | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIP
 | | Structure of PfGrx1 with manganese | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.731 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIR
 | | Structure of PfGrx1 with mercury | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIW
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7DIT
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7DIM
 | | Structure of PfGrx1 with cadmium | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CADMIUM ION, ... | | Authors: | Manickam, Y, Sharma, A. | | Deposit date: | 2020-11-19 | | Release date: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Interaction of metals with PfGrx1
To Be Published
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7DIZ
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7DIV
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7DJ0
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5ZKH
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7VC5
 | | Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Febrifugine (FF) at 1.61 A resolution | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... | | Authors: | Manickam, Y, Malhotra, N, Sharma, A. | | Deposit date: | 2021-09-01 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.612 Å) | | Cite: | TgPRS with double inhibitors
To Be Published
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7EVU
 | | Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with HFG and JE6 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Prolyl-tRNA synthetase (ProRS), ... | | Authors: | Mishra, S, Malhotra, N, Manickam, Y, Sharma, A. | | Deposit date: | 2021-05-22 | | Release date: | 2022-03-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
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7EVV
 | | Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with JE6 and L-pro | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PROLINE, ... | | Authors: | Malhotra, N, Mishra, S, Manickam, Y, Sharma, A. | | Deposit date: | 2021-05-22 | | Release date: | 2022-03-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.704 Å) | | Cite: | Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
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7F9U
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