Author results

3E7R
  • Download 3e7r
  • View 3e7r
Molmil generated image of 3e7r
X-RAY CRYSTAL STRUCTURE OF RACEMIC PLECTASIN
Descriptor:Plectasin
Authors:Mandal, K., Pentelute, B.L., Tereshko, V., Kossiakoff, A.A., Kent, S.B.H.
Deposit date:2008-08-18
Release date:2009-06-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1 Å)
Cite:Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods
Protein Sci., 18, 2009
3E7U
  • Download 3e7u
  • View 3e7u
Molmil generated image of 3e7u
X-RAY CRYSTAL STRUCTURE OF L-PLECTASIN
Descriptor:Plectasin
Authors:Mandal, K., Pentelute, B.L., Tereshko, V., Kossiakoff, A.A., Kent, S.B.H.
Deposit date:2008-08-18
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods
Protein Sci., 18, 2009
3E8Y
  • Download 3e8y
  • View 3e8y
Molmil generated image of 3e8y
XRAY STRUCTURE OF SCORPION TOXIN BMBKTX1
Descriptor:Potassium channel toxin alpha-KTx 19.1, CHLORIDE ION, SULFATE ION
Authors:Mandal, K., Pentelute, B.L., Tereshko, V., Kossiakoff, A.A., Kent, S.B.H.
Deposit date:2008-08-20
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.
J.Am.Chem.Soc., 131, 2009
3QTK
  • Download 3qtk
  • View 3qtk
Molmil generated image of 3qtk
THE CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED VEGF-A
Descriptor:Vascular endothelial growth factor A, ACETATE ION, trifluoroacetic acid, ...
Authors:Mandal, K., Kent, S.B.H.
Deposit date:2011-02-22
Release date:2011-07-27
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
3UE7
  • Download 3ue7
  • View 3ue7
Molmil generated image of 3ue7
X-RAY CRYSTAL STRUCTURE OF A NOVEL TOPOLOGICAL ANALOGUE OF CRAMBIN
Descriptor:D-Crambin, Crambin
Authors:Mandal, K., Pentelute, B.L., Bang, D., Gates, Z.P., Torbeev, V.Y., Kent, S.B.H.
Deposit date:2011-10-28
Release date:2012-02-08
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Design, total chemical synthesis, and x-ray structure of a protein having a novel linear-loop polypeptide chain topology.
Angew.Chem.Int.Ed.Engl., 51, 2012
4GLN
  • Download 4gln
  • View 4gln
Molmil generated image of 4gln
CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HETEROCHIRAL {D-PROTEIN ANTAGONIST PLUS VEGF-A} PROTEIN COMPLEX IN SPACE GROUP P21/N
Descriptor:D-RFX001, Vascular endothelial growth factor A
Authors:Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S., Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GLS
  • Download 4gls
  • View 4gls
Molmil generated image of 4gls
CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HETEROCHIRAL {D-PROTEIN ANTAGONIST PLUS VEGF-A} PROTEIN COMPLEX IN SPACE GROUP P21
Descriptor:D- Vascular endothelial growth factor-A, L- RFX001, D- RFX001, ...
Authors:Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S., Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GLU
  • Download 4glu
  • View 4glu
Molmil generated image of 4glu
CRYSTAL STRUCTURE OF THE MIRROR IMAGE FORM OF VEGF-A
Descriptor:D- Vascular endothelial growth factor-A, ACETATE ION, trifluoroacetic acid, ...
Authors:Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S., Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
5EN9
  • Download 5en9
  • View 5en9
Molmil generated image of 5en9
HIGH RESOLUTION X-RAY CRYSTAL STRUCTURE OF ISOTOPE-LABELED ESTER-INSULIN
Descriptor:Insulin chain A, Insulin chain B
Authors:Mandal, K., Dhayalan, B., Avital-Shmilovici, M., Tokmakoff, A., Kent, S.B.H.
Deposit date:2015-11-09
Release date:2016-01-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
5ENA
  • Download 5ena
  • View 5ena
Molmil generated image of 5ena
XRAY CRYSTAL STRUCTURE OF ISOTOPE-LABELED HUMAN INSULIN
Descriptor:Insulin chain A, Insulin chain B
Authors:Mandal, K., Dhayalan, B., Avital-Shmilovici, M., Tokmakoff, A., Kent, S.B.H.
Deposit date:2015-11-09
Release date:2016-01-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
5UDP
  • Download 5udp
  • View 5udp
Molmil generated image of 5udp
HIGH RESOLUTION X-RAY CRYSTAL STRUCTURE OF SYNTHETIC INSULIN LISPRO
Descriptor:Insulin Lispro A chain, Insulin Lispro B chain, PHENOL, ...
Authors:Mandal, K., Dhayalan, B., Kent, S.B.H.
Deposit date:2016-12-28
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.348 Å)
Cite:Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.
Chemistry, 23, 2017
3DCK
  • Download 3dck
  • View 3dck
Molmil generated image of 3dck
X-RAY STRUCTURE OF D25N CHEMICAL ANALOGUE OF HIV-1 PROTEASE COMPLEXED WITH KETOMETHYLENE ISOSTERE INHIBITOR
Descriptor:Chemical analogue HIV-1 protease, (2S)-2-{[(2R,5S)-5-{[(2S,3S)-2-{[(2S,3R)-2-(acetylamino)-3-hydroxybutanoyl]amino}-3-methylpentanoyl]amino}-2-butyl-4-oxononanoyl]amino}-N~1~-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]pentanediamide
Authors:Torbeev, V.Y., Mandal, K., Terechko, V.A., Kent, S.B.H.
Deposit date:2008-06-03
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site
Bioorg.Med.Chem.Lett., 18, 2008
3DCR
  • Download 3dcr
  • View 3dcr
Molmil generated image of 3dcr
X-RAY STRUCTURE OF HIV-1 PROTEASE AND HYDRATED FORM OF KETOMETHYLENE ISOSTERE INHIBITOR
Descriptor:Chemical analogue HIV-1 protease, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide
Authors:Torbeev, V.Y., Mandal, K., Terechko, V.A., Kent, S.B.H.
Deposit date:2008-06-04
Release date:2008-08-19
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site
Bioorg.Med.Chem.Lett., 18, 2008
3NGG
  • Download 3ngg
  • View 3ngg
Molmil generated image of 3ngg
X-RAY STRUCTURE OF OMWAPRIN
Descriptor:Omwaprin-a
Authors:Banigan, J.R., Mandal, K., Sawaya, M.R., Thammavongsa, V., Hendrickx, A.P.A., Schneewind, O., Yeates, T.O., Kent, S.B.H.
Deposit date:2010-06-11
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography.
Protein Sci., 19, 2010
3ODV
  • Download 3odv
  • View 3odv
Molmil generated image of 3odv
X-RAY STRUCTURE OF KALIOTOXIN BY RACEMIC PROTEIN CRYSTALLOGRAPHY
Descriptor:Potassium channel toxin alpha-KTx 3.1, trifluoroacetic acid, CITRIC ACID
Authors:Pentelute, B.L., Mandal, K., Gates, Z.P., Sawaya, M.R., Yeates, T.O., Kent, S.B.H.
Deposit date:2010-08-11
Release date:2010-10-20
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.
Chem.Commun.(Camb.), 46, 2010
4IUZ
  • Download 4iuz
  • View 4iuz
Molmil generated image of 4iuz
HIGH RESOLUTION CRYSTAL STRUCTURE OF RACEMIC ESTER INSULIN
Descriptor:Insulin A chain, Insulin B chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Avital-Shmilovici, M., Mandal, K., Gates, Z.P., Phillips, N., Weiss, M.A., Kent, S.B.H.
Deposit date:2013-01-22
Release date:2013-02-13
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
4LFQ
  • Download 4lfq
  • View 4lfq
Molmil generated image of 4lfq
HIGH RESOLUTION X-RAY CRYSTAL STRUCTURE OF L-SHK TOXIN
Descriptor:Potassium channel toxin ShK
Authors:Dang, B., Kubota, T., Mandal, K., Bezanilla, F., Kent, S.B.H.
Deposit date:2013-06-27
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.059 Å)
Cite:Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
4LFS
  • Download 4lfs
  • View 4lfs
Molmil generated image of 4lfs
HIGH RESOLUTION X-RAY STRUCTURE OF RACEMIC SHK TOXIN
Descriptor:Potassium channel toxin ShK, CHLORIDE ION, GLYCEROL
Authors:Dang, B., Kubota, T., Mandal, K., Bezanilla, F., Kent, S.B.H.
Deposit date:2013-06-27
Release date:2013-08-14
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High-Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135, 2013
4OIJ
  • Download 4oij
  • View 4oij
Molmil generated image of 4oij
X-RAY CRYSTAL STRUCTURE OF RACEMIC NON-GLYCOSYLATED CHEMOKINE SER-CCL1
Descriptor:C-C motif chemokine 1, D-Ser-CCL1, SULFATE ION
Authors:Okamoto, R., Mandal, K., Sawaya, M.R., Kajihara, Y., Yeates, T.O., Kent, S.B.H.
Deposit date:2014-01-19
Release date:2014-05-07
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:(Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis.
Angew.Chem.Int.Ed.Engl., 53, 2014
4OIK
  • Download 4oik
  • View 4oik
Molmil generated image of 4oik
(QUASI-)RACEMIC X-RAY CRYSTAL STRUCTURE OF GLYCOSYLATED CHEMOKINE SER-CCL1.
Descriptor:C-C motif chemokine 1, D-Ser-CCL1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Okamoto, R., Mandal, K., Sawaya, M.R., Kajihara, Y., Yeates, T.O., Kent, S.B.H.
Deposit date:2014-01-19
Release date:2014-05-07
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis.
Angew.Chem.Int.Ed.Engl., 53, 2014
4WPY
  • Download 4wpy
  • View 4wpy
Molmil generated image of 4wpy
RACEMIC CRYSTAL STRUCTURE OF RV1738 FROM MYCOBACTERIUM TUBERCULOSIS (FORM-II)
Descriptor:protein DL-Rv1738, trifluoroacetic acid, GLYCEROL
Authors:Bunker, R.D., Mandal, K., Kent, S.B.H., Baker, E.N.
Deposit date:2014-10-21
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WSP
  • Download 4wsp
  • View 4wsp
Molmil generated image of 4wsp
RACEMIC CRYSTAL STRUCTURE OF RV1738 FROM MYCOBACTERIUM TUBERCULOSIS (FORM-I)
Descriptor:protein DL-Rv1738, CHLORIDE ION
Authors:Bunker, R.D., Mandal, K., Kent, S.B.H., Baker, E.N.
Deposit date:2014-10-28
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CY0
  • Download 5cy0
  • View 5cy0
Molmil generated image of 5cy0
TOTAL CHEMICAL SYNTHESIS, COVALENT STRUCTURE VERIFICATION, AND X-RAY STRUCTURE OF BIOACTIVE TS3 TOXIN BY RACEMIC PROTEIN CRYSTALLOGRAPHY
Descriptor:Ts3 Toxin, GLYCEROL
Authors:Dang, B., Kubota, T., Mandal, K., Correa, A.M., Bezanilla, F., Kent, S.B.
Deposit date:2015-07-29
Release date:2016-06-01
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin.
Angew.Chem.Int.Ed.Engl., 55, 2016
5HHC
  • Download 5hhc
  • View 5hhc
Molmil generated image of 5hhc
CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HETEROCHIRAL {RFX037 PLUS VEGF-A} PROTEIN COMPLEX IN SPACE GROUP P21/N
Descriptor:Vascular endothelial growth factor A, D- Vascular endothelial growth factor-A, GLYCEROL
Authors:Uppalapati, M., Lee, D.J., Mandal, K., Kent, S.B.H., Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
5HHD
  • Download 5hhd
  • View 5hhd
Molmil generated image of 5hhd
CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HETEROCHIRAL {RFX037 PLUS VEGF-A} PROTEIN COMPLEX IN SPACE GROUP P21
Descriptor:Vascular endothelial growth factor A, D-Peptide RFX037.D, D-Vascular endothelial growth factor, ...
Authors:Uppalapati, M., LEE, D.J., Mandal, K., Kent, S.B.H., Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
<12>