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6DWE
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - AMINOACRYLATE- AND BRD0059-BOUND FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-06-26
Release date:2018-07-11
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.691 Å)
Cite:Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound
To be Published
6E9P
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - OPEN FORM WITH BRD0059 BOUND
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONIC ACID, ...
Authors:Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-08-01
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound
To be Published
6UAP
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - OPEN FORM WITH BRD6309 BOUND
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, FORMIC ACID, ...
Authors:Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-09-11
Release date:2019-10-30
Method:X-RAY DIFFRACTION (2.745 Å)
Cite:Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound
To be Published
6UB9
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - AMINOACRYLATE- AND BRD6309-BOUND FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, FORMIC ACID, ...
Authors:Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-09-11
Release date:2019-09-25
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.783 Å)
Cite:Crystal structure of tryptophan synthase from M. tuberculosis - AMINOACRYLATE- AND BRD6309-BOUND FORM
To be Published
6XKF
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH OXIDIZED CYS145 (SULFENIC ACID CYSTEINE).
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Coates, L., Kovalevskyi, A.Y., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-06-26
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of 3CL MainPro of SARS-CoV-2 with oxidized Cys145 (Sulfenic acid cysteine).
To Be Published
6XKH
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THE 1.28A CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH OXIDIZED C145 (SULFINIC ACID CYSTEINE)
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL, FORMIC ACID, ...
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Coates, L., Kovalevsky, A., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-06-26
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:THE 1.28A CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH OXIDIZED C145 (sulfinic acid cysteine)
To Be Published
6XOA
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH C145S MUTATION
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-06
Release date:2020-07-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation
To Be Published
7JFQ
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH DE-OXIDIZED C145
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-17
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
To Be Published
6VWW
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CRYSTAL STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2.
Descriptor:Uridylate-specific endoribonuclease, GLYCEROL, MAGNESIUM ION, ...
Authors:Kim, Y., Jedrzejczak, R., Maltseva, N., Endres, M., Godzik, A., Michalska, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-02-20
Release date:2020-03-04
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Protein Sci., 29, 2020
5TCF
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - LIGAND-FREE FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Michalska, K., Maltseva, N., Jedrzejczak, R., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-09-15
Release date:2017-05-31
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat. Chem. Biol., 13, 2017
5TCG
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - AMINOACRYLATE-BOUND FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Michalska, K., Maltseva, N., Jedrzejczak, R., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-09-15
Release date:2017-05-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat. Chem. Biol., 13, 2017
5TCH
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - LIGAND-FREE FORM, TRPA-G66V MUTANT
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-09-15
Release date:2017-05-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat. Chem. Biol., 13, 2017
5TCI
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - BRD4592-BOUND FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-09-15
Release date:2017-05-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat. Chem. Biol., 13, 2017
5TCJ
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CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM M. TUBERCULOSIS - AMINOACRYLATE AND BRD4592-BOUND FORM
Descriptor:Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ...
Authors:Michalska, K., Maltseva, N., Jedrzejczak, R., Wellington, S., Nag, P.P., Fisher, S.L., Schreiber, S.L., Hung, D.T., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-09-15
Release date:2017-05-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat. Chem. Biol., 13, 2017
6W01
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THE 1.9 A CRYSTAL STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2 IN THE COMPLEX WITH A CITRATE
Descriptor:Uridylate-specific endoribonuclease, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Kim, Y., Jedrzejczak, R., Maltseva, N., Endres, M., Godzik, A., Michalska, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-02-28
Release date:2020-03-11
Last modified:2020-07-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Protein Sci., 29, 2020
167518
PDB entries from 2020-08-12