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1IGX
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CRYSTAL STRUCTURE OF EICOSAPENTANOIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.
Descriptor:Prostaglandin Endoperoxide H Synthase-1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Malkowski, M.G., Thuresson, E.D., Smith, W.L., Garavito, R.M.
Deposit date:2001-04-18
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
1IGZ
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CRYSTAL STRUCTURE OF LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.
Descriptor:Prostaglandin Endoperoxide H Synthase-1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Malkowski, M.G., Thuresson, E.D., Smith, W.L., Garavito, R.M.
Deposit date:2001-04-18
Release date:2001-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
1MKW
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1TVX
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NEUTROPHIL ACTIVATING PEPTIDE-2 VARIANT FORM M6L WITH FIVE ADDITIONAL AMINO TERMINAL RESIDUES (DSDLY)
Descriptor:NEUTROPHIL ACTIVATING PEPTIDE 2 VARIANT
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1996-11-05
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence.
J.Mol.Biol., 266, 1997
1YCP
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THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
Descriptor:EPSILON THROMBIN, ALPHA THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-05-01
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
1DIY
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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1
Descriptor:PROSTAGLANDIN H2 SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Malkowski, M.G., Ginell, S.L., Smith, W.L., Garavito, R.M.
Deposit date:1999-11-30
Release date:2000-09-22
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The productive conformation of arachidonic acid bound to prostaglandin synthase.
Science, 289, 2000
1NAP
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THE CRYSTAL STRUCTURE OF RECOMBINANT HUMAN NEUTROPHIL-ACTIVATING PEPTIDE-2 (M6L) AT 1.9-ANGSTROMS RESOLUTION
Descriptor:NEUTROPHIL ACTIVATING PEPTIDE-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1994-12-19
Release date:1995-12-19
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.
J.Biol.Chem., 270, 1995
2IP1
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CRYSTAL STRUCTURE ANALYSIS OF S. CEREVISIAE TRYPTOPHANYL TRNA SYNTHETASE
Descriptor:Tryptophanyl-tRNA synthetase, TETRAETHYLENE GLYCOL
Authors:Malkowski, M.G., Center for High-Throughput Structural Biology (CHTSB)
Deposit date:2006-10-11
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5JVZ
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CRYSTAL STRUCTURE OF FLURBIPROFEN BOUND TO S121P MURINE COX-2 MUTANT
Descriptor:Prostaglandin G/H synthase 2, FLURBIPROFEN, B-OCTYLGLUCOSIDE, ...
Authors:Malkowski, M.G., Orlando, B.J.
Deposit date:2016-05-11
Release date:2016-10-26
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.
J.Biol.Chem., 291, 2016
5JW1
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CRYSTAL STRUCTURE OF CELECOXIB BOUND TO S121P MURINE COX-2 MUTANT
Descriptor:Prostaglandin G/H synthase 2, PROTOPORPHYRIN IX CONTAINING CO, 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, ...
Authors:Malkowski, M.G., Orlando, B.J.
Deposit date:2016-05-11
Release date:2016-10-26
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.822 Å)
Cite:Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.
J.Biol.Chem., 291, 2016
1FE2
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CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.
Descriptor:PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Thuresson, E.D., Malkowski, M.G., Lakkides, K.M., Smith, W.L., Garavito, R.M.
Deposit date:2000-07-20
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.
J.Biol.Chem., 276, 2001
1A0H
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THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Descriptor:MEIZOTHROMBIN, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, N-ACETYL-D-GLUCOSAMINE
Authors:Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.P.
Deposit date:1997-11-30
Release date:1998-06-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Structure, 5, 1997
3HS5
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X-RAY CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE CHANNEL OF CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, ARACHIDONIC ACID, ACRYLIC ACID, ...
Authors:Vecchio, A.J., Simmons, D.M., Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS6
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X-RAY CRYSTAL STRUCTURE OF EICOSAPENTAENOIC ACID BOUND TO THE CYCLOOXYGENASE CHANNEL OF CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, 5,8,11,14,17-EICOSAPENTAENOIC ACID, ACRYLIC ACID, ...
Authors:Vecchio, A.J., Simmons, D.M., Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS7
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X-RAY CRYSTAL STRUCTURE OF DOCOSAHEXAENOIC ACID BOUND TO THE CYCLOOXYGENASE CHANNEL OF CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, ACRYLIC ACID, PROTOPORPHYRIN IX CONTAINING CO, ...
Authors:Vecchio, A.J., Simmons, D.M., Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3K8G
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STRUCTURE OF CRYSTAL FORM I OF TP0453
Descriptor:30kLP, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3K8H
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STRUCTURE OF CRYSTAL FORM I OF TP0453
Descriptor:30kLP, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3K8I
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STRUCTURE OF CRYSTAL FORM IV OF TP0453
Descriptor:30kLP
Authors:Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3K8J
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STRUCTURE OF CRYSTAL FORM III OF TP0453
Descriptor:30kLP
Authors:Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.
Deposit date:2009-10-14
Release date:2010-10-27
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.
J.Biol.Chem., 286, 2011
3KRK
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X-RAY CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF L531F MURINE COX-2
Descriptor:Prostaglandin G/H synthase 2, ARACHIDONIC ACID, ACRYLIC ACID, ...
Authors:Vecchio, A.J., Simmons, D.M., Malkowski, M.G.
Deposit date:2009-11-18
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3MDL
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X-RAY CRYSTAL STRUCTURE OF 1-ARACHIDONOYL GLYCEROL BOUND TO THE CYCLOOXYGENASE CHANNEL OF CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, ACRYLIC ACID, ...
Authors:Vecchio, A.J., Malkowski, M.G.
Deposit date:2010-03-30
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3OLT
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X-RAY CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE CHANNEL OF R513H MURINE COX-2
Descriptor:Prostaglandin G/H synthase 2, 1,2-ETHANEDIOL, ARACHIDONIC ACID, ...
Authors:Vecchio, A.J., Malkowski, M.G.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3OLU
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X-RAY CRYSTAL STRUCTURE OF 1-ARACHIDONOYL GLYCEROL BOUND TO THE CYCLOOXYGENASE CHANNEL OF R513H MURINE COX-2
Descriptor:Prostaglandin G/H synthase 2, 1,2-ETHANEDIOL, (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, ...
Authors:Vecchio, A.J., Malkowski, M.G.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3QH0
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X-RAY CRYSTAL STRUCTURE OF PALMITIC ACID BOUND TO THE CYCLOOXYGENASE CHANNEL OF CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, 1,2-ETHANEDIOL, PALMITIC ACID, ...
Authors:Vecchio, A.J., Malkowski, M.G.
Deposit date:2011-01-25
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.
J.Biol.Chem., 286, 2011
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