Author results

2YGN
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WIF DOMAIN OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2- DIPALMITOYLPHOSPHATIDYLCHOLINE
Descriptor:WNT INHIBITORY FACTOR 1, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malinauskas, T., Aricescu, A.R., Lu, W., Siebold, C., Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YGO
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WIF DOMAIN-EGF-LIKE DOMAIN 1 OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE
Descriptor:WNT INHIBITORY FACTOR 1, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malinauskas, T., Aricescu, A.R., Lu, W., Siebold, C., Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YGP
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WIF DOMAIN-EGF-LIKE DOMAIN 1 MET77TRP OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE
Descriptor:WNT INHIBITORY FACTOR 1, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malinauskas, T., Aricescu, A.R., Lu, W., Siebold, C., Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YGQ
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WIF DOMAIN-EPIDERMAL GROWTH FACTOR (EGF)-LIKE DOMAINS 1-3 OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2- DIPALMITOYLPHOSPHATIDYLCHOLINE
Descriptor:WNT INHIBITORY FACTOR 1, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, ...
Authors:Malinauskas, T., Aricescu, A.R., Lu, W., Siebold, C., Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.951 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
6Z3G
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REPULSIVE GUIDANCE MOLECULE A (RGMA) IN COMPLEX WITH GROWTH DIFFERENTIATION FACTOR 5 (GDF5)
Descriptor:Growth/differentiation factor 5, Repulsive guidance molecule A, CITRIC ACID
Authors:Malinauskas, T., Peer, T.V., Bishop, B., Muller, T.D., Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z3H
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REPULSIVE GUIDANCE MOLECULE B (RGMB) IN COMPLEX WITH GROWTH DIFFERENTIATION FACTOR 5 (GDF5) (CRYSTAL FORM 2)
Descriptor:Growth/differentiation factor 5, RGM domain family member B
Authors:Malinauskas, T., Peer, T.V., Bishop, B., Muller, T.D., Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (3.158 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z3J
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REPULSIVE GUIDANCE MOLECULE B (RGMB) IN COMPLEX WITH GROWTH DIFFERENTIATION FACTOR 5 (GDF5) (CRYSTAL FORM 1)
Descriptor:Growth/differentiation factor 5, RGM domain family member B, SULFATE ION, ...
Authors:Malinauskas, T., Peer, T.V., Bishop, B., Muller, T.D., Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z3L
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REPULSIVE GUIDANCE MOLECULE C (RGMC, HEMOJUVELIN, HJV, HFE2) IN COMPLEX WITH GROWTH DIFFERENTIATION FACTOR 5 (GDF5)
Descriptor:Growth/differentiation factor 5, Hemojuvelin
Authors:Malinauskas, T., Peer, T.V., Bishop, B., Muller, T.D., Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (2.513 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
6Z3M
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REPULSIVE GUIDANCE MOLECULE B (RGMB) IN COMPLEX WITH GROWTH DIFFERENTIATION FACTOR 5 (GDF5) AND NEOGENIN 1 (NEO1)
Descriptor:Growth/differentiation factor 5, RGM domain family member B, Neogenin, ...
Authors:Malinauskas, T., Peer, T.V., Bishop, B., Muller, T.D., Siebold, C.
Deposit date:2020-05-21
Release date:2020-07-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (5.501 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
5L56
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PLEXIN A1 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 10, TO 4 ANGSTROM
Descriptor:Plexin-A1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L59
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PLEXIN A1 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 10, TO 6 ANGSTROM, SPACEGROUP P2(1)
Descriptor:Plexin-A1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5C
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PLEXIN A1 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 10, TO 6 ANGSTROM, SPACEGROUP P4(3)2(1)2
Descriptor:Plexin-A1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5G
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PLEXIN A2 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 8 MODELED, DATA TO 10 ANGSTROM
Descriptor:Plexin-A2
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (10 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5K
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PLEXIN A4 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 10, DATA TO 7.5 ANGSTROM, SPACEGROUP P4(1)
Descriptor:Plexin-A4
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (7.501 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5L
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PLEXIN A4 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 8 MODELED, DATA TO 8 ANGSTROM, SPACEGROUP P2(1)
Descriptor:Plexin-A4
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (8.001 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5M
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PLEXIN A4 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 7 MODELED, DATA TO 8 ANGSTROM, SPACEGROUP P4(3)2(1)2
Descriptor:Plexin-A4
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (8 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L5N
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PLEXIN A4 FULL EXTRACELLULAR REGION, DOMAINS 1 TO 7 MODELED, DATA TO 8.5 ANGSTROM, SPACEGROUP P4(3)22
Descriptor:Plexin-A4
Authors:Janssen, B.J.C., Kong, Y., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-05-28
Release date:2016-07-06
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (8.502 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L74
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PLEXIN A2 EXTRACELLULAR SEGMENT DOMAINS 4-5 (PSI2-IPT2), RESOLUTION 1.36 ANGSTROM
Descriptor:Plexin-A2, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ...
Authors:Kong, Y., Janssen, B.J.C., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-06-01
Release date:2017-03-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
5L7N
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PLEXIN A1 EXTRACELLULAR FRAGMENT, DOMAINS 7-10 (IPT3-IPT6)
Descriptor:Plexin-A1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ...
Authors:Kong, Y., Janssen, B.J.C., Malinauskas, T., Vangoor, V.R., Coles, C.H., Kaufmann, R., Ni, T., Gilbert, R.J.C., Padilla-Parra, S., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2016-06-03
Release date:2017-03-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Plexin Activation and Regulation.
Neuron, 91, 2016
6HUG
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CRYOEM STRUCTURE OF HUMAN FULL-LENGTH ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH PICROTOXIN AND MEGABODY MB38.
Descriptor:Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUJ
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CRYOEM STRUCTURE OF HUMAN FULL-LENGTH HETEROMERIC ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH PICROTOXIN, GABA AND MEGABODY MB38.
Descriptor:Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUK
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CRYOEM STRUCTURE OF HUMAN FULL-LENGTH ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH BICUCULLINE AND MEGABODY MB38.
Descriptor:Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUO
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CRYOEM STRUCTURE OF HUMAN FULL-LENGTH HETEROMERIC ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH ALPRAZOLAM (XANAX), GABA AND MEGABODY MB38.
Descriptor:Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-10-09
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUP
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CRYOEM STRUCTURE OF HUMAN FULL-LENGTH ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH DIAZEPAM (VALIUM), GABA AND MEGABODY MB38.
Descriptor:Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Jasenko, Z., Pardon, E., Kotecha, A., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-10-09
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6I53
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CRYO-EM STRUCTURE OF THE HUMAN SYNAPTIC ALPHA1-BETA3-GAMMA2 GABAA RECEPTOR IN COMPLEX WITH MEGABODY38 IN A LIPID NANODISC
Descriptor:Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit gamma-2, ...
Authors:Laverty, D., Desai, R., Uchanski, T., Masiulis, S., Wojciech, J.S., Malinauskas, T., Zivanov, J., Pardon, E., Steyaert, J., Miller, K.W., Aricescu, A.R.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer.
Nature, 565, 2019
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170172
PDB entries from 2020-10-21