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6EHT
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MODULATION OF PCNA SLIDING SURFACE BY P15PAF SUGGESTS A SUPPRESSIVE MECHANISM FOR CISPLATIN-INDUCED DNA LESION BYPASS BY POL ETA HOLOENZYME
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ...
Authors:De March, M., Barrera-Vilarmau, S., Mentegari, E., Merino, N., Bressan, E., Maga, G., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2017-09-15
Release date:2018-08-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
3ISN
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CRYSTAL STRUCTURE OF HIV-1 RT BOUND TO A 6-VINYLPYRIMIDINE INHIBITOR
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine
Authors:Ennifar, E., Freisz, S., Bec, G., Dumas, P., Botta, M., Radi, M.
Deposit date:2009-08-26
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action
Angew.Chem.Int.Ed.Engl., 49, 2010
3ITH
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CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A 6-VINYLPYRIMIDINE INHIBITOR
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 6-ethenyl-N,N-dimethyl-2-(methylsulfonyl)pyrimidin-4-amine
Authors:Freisz, S., Bec, G., Wolff, P., Dumas, P., Radi, M., Botta, M.
Deposit date:2009-08-28
Release date:2010-03-16
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action
Angew.Chem.Int.Ed.Engl., 49, 2010
4IQT
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TDT CORE IN COMPLEX WITH INHIBITOR 6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC ACID
Descriptor:DNA nucleotidylexotransferase, 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid
Authors:Gouge, J., Delarue, M.
Deposit date:2013-01-13
Release date:2013-09-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J.Med.Chem., 56, 2013
4IQU
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TDT CORE IN COMPLEX WITH INHIBITOR (2Z,5E)-6-[4-(4-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC ACID
Descriptor:DNA nucleotidylexotransferase, SODIUM ION, (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid
Authors:Gouge, J., Delarue, M.
Deposit date:2013-01-13
Release date:2013-09-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J.Med.Chem., 56, 2013
4IQV
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TDT CORE IN COMPLEX WITH INHIBITOR 6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC ACID AND SSDNA
Descriptor:DNA nucleotidylexotransferase, 5'-D(*GP*CP*CP*G)-3', SODIUM ION, ...
Authors:Gouge, J., Delarue, M.
Deposit date:2013-01-13
Release date:2013-09-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J.Med.Chem., 56, 2013
4IQW
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TDT CORE IN COMPLEX WITH INHIBITOR (2Z,5E)-6-[4-(4-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC ACID AND SSDNA
Descriptor:DNA nucleotidylexotransferase, 5'-D(*GP*CP*CP*G)-3', SODIUM ION, ...
Authors:Gouge, J., Delarue, M.
Deposit date:2013-01-13
Release date:2013-09-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J.Med.Chem., 56, 2013
4O2P
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KINASE DOMAIN OF CSRC IN COMPLEX WITH A SUBSTITUTED PYRAZOLOPYRIMIDINE
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Richters, A., Rauh, D.
Deposit date:2013-12-17
Release date:2015-03-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.
J.Med.Chem., 58, 2015
6GWS
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE P15 PEPTIDES
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor
Authors:De March, M., Merino, N., Gonzalez-Magana, A., Romano-Moreno, M., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-06-25
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018