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6WJC
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BU of 6wjc by Molmil
Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex
Descriptor: (1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE, ACETAMIDE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Maeda, S, Kobilka, B.K.
Deposit date:2020-04-13
Release date:2020-07-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and selectivity engineering of the M1muscarinic receptor toxin complex.
Science, 369, 2020
6CRK
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BU of 6crk by Molmil
Heterotrimeric G-protein in complex with an antibody fragment
Descriptor: CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Maeda, S, Dawson, R, Kobilka, B.
Deposit date:2018-03-19
Release date:2018-10-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an antibody fragment that stabilizes GPCR/G-protein complexes.
Nat Commun, 9, 2018
2ZW3
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BU of 2zw3 by Molmil
Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution
Descriptor: Gap junction beta-2 protein
Authors:Maeda, S, Nakagawa, S, Suga, M, Yamashita, E, Oshima, A, Fujiyoshi, Y, Tsukihara, T.
Deposit date:2008-12-01
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the connexin 26 gap junction channel at 3.5 A resolution
Nature, 458, 2009
7JLQ
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BU of 7jlq by Molmil
cryo-EM structure of human ATG9A in LMNG micelles
Descriptor: Autophagy-related protein 9A
Authors:Maeda, S, Otomo, T.
Deposit date:2020-07-30
Release date:2020-10-28
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
7JLO
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BU of 7jlo by Molmil
Cryo-EM structure of human ATG9A in amphipols
Descriptor: Autophagy-related protein 9A
Authors:Maeda, S, Otomo, T.
Deposit date:2020-07-30
Release date:2020-10-28
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
7JLP
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BU of 7jlp by Molmil
cryo-EM structure of human ATG9A in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Autophagy-related protein 9A
Authors:Maeda, S, Otomo, T.
Deposit date:2020-07-30
Release date:2020-10-28
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Nat.Struct.Mol.Biol., 27, 2020
6OIJ
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BU of 6oij by Molmil
Muscarinic acetylcholine receptor 1-G11 protein complex
Descriptor: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, CHOLESTEROL HEMISUCCINATE, ...
Authors:Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
6OIK
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BU of 6oik by Molmil
Muscarinic acetylcholine receptor 2-Go complex
Descriptor: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ...
Authors:Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
7T5P
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BU of 7t5p by Molmil
Cryo-EM structure of human SIMC1-SLF2 complex
Descriptor: SMC5-SMC6 complex localization factor protein 2, SUMO-interacting motif-containing protein 1
Authors:Maeda, S, Oravcova, M, Boddy, M.N, Otomo, T.
Deposit date:2021-12-13
Release date:2022-12-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.
Elife, 11, 2022
7C4S
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BU of 7c4s by Molmil
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ...
Authors:Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.
Sci Adv, 7, 2021
6DDE
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BU of 6dde by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDF
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BU of 6ddf by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6QNO
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BU of 6qno by Molmil
Rhodopsin-Gi protein complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab antibody fragment heavy chain, Fab antibody fragment light chain, ...
Authors:Tsai, C.-J, Marino, J, Adaixo, R.J, Pamula, F, Muehle, J, Maeda, S, Flock, T, Taylor, N.M.I, Mohammed, I, Matile, H, Dawson, R.J.P, Deupi, X, Stahlberg, H, Schertler, G.F.X.
Deposit date:2019-02-11
Release date:2019-07-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit.
Elife, 8, 2019
6QNK
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BU of 6qnk by Molmil
Antibody FAB fragment targeting Gi protein heterotrimer
Descriptor: 1,2-ETHANEDIOL, D-MALATE, FAB heavy chain, ...
Authors:Tsai, C.-J, Muehle, J, Pamula, F, Dawson, R.J.P, Maeda, S, Deupi, X, Schertler, G.F.X.
Deposit date:2019-02-11
Release date:2019-07-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit.
Elife, 8, 2019
7RKF
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BU of 7rkf by Molmil
Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ...
Authors:Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
5YC8
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BU of 5yc8 by Molmil
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative)
Descriptor: MERCURY (II) ION, Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2017-09-06
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZK8
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BU of 5zk8 by Molmil
Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS
Descriptor: Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKB
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BU of 5zkb by Molmil
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384
Descriptor: Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKC
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BU of 5zkc by Molmil
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS
Descriptor: Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZK3
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BU of 5zk3 by Molmil
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB
Descriptor: (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2
Authors:Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5GJE
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BU of 5gje by Molmil
Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Matoba, K, Mihara, E, Tamura-Kawakami, K, Hirai, H, Thompson, S, Iwasaki, K, Takagi, J.
Deposit date:2016-06-29
Release date:2017-01-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (21 Å)
Cite:Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1
Cell Rep, 18, 2017
6IOL
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BU of 6iol by Molmil
Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)
Descriptor: Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM
Authors:Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E.
Deposit date:2018-10-30
Release date:2019-04-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
6IOK
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BU of 6iok by Molmil
Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state)
Descriptor: Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM
Authors:Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E.
Deposit date:2018-10-30
Release date:2019-04-03
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
7RKN
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BU of 7rkn by Molmil
Structure of CX3CL1-US28-Gi-scFv16 in OC-state
Descriptor: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKM
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BU of 7rkm by Molmil
Structure of CX3CL1-US28-Gi-scFv16 in C-state
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022

 

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