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2YH1
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BU of 2yh1 by Molmil
Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding
Descriptor: 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3', SPLICING FACTOR U2AF 65 KDA SUBUNIT
Authors:Mackereth, C.D, Madl, T, Simon, B, Zanier, K, Gasch, A, Sattler, M.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2019-09-25
Method:SOLUTION NMR
Cite:Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af
Nature, 475, 2011
2YH0
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BU of 2yh0 by Molmil
Solution structure of the closed conformation of human U2AF65 tandem RRM1 and RRM2 domains
Descriptor: SPLICING FACTOR U2AF 65 KDA SUBUNIT
Authors:Mackereth, C.D, Madl, T, Simon, B, Zanier, K, Gasch, A, Sattler, M.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2019-09-25
Method:SOLUTION NMR
Cite:Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af
Nature, 475, 2011
1SXE
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BU of 1sxe by Molmil
The solution structure of the Pointed (PNT) domain from the transcrition factor Erg
Descriptor: Transcriptional regulator ERG
Authors:Mackereth, C.D, Schaerpf, M, Gentile, L.N, MacIntosh, S.E, Slupsky, C.M, McIntosh, L.P.
Deposit date:2004-03-30
Release date:2004-09-21
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Diversity in Structure and Function of the Ets Family PNT Domains.
J.Mol.Biol., 342, 2004
1SXD
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BU of 1sxd by Molmil
Solution Structure of the Pointed (PNT) Domain from mGABPa
Descriptor: GA repeat binding protein, alpha
Authors:Mackereth, C.D, Schaerpf, M, Gentile, L.N, MacIntosh, S.E, Slupsky, C.M, McIntosh, L.P.
Deposit date:2004-03-30
Release date:2004-09-21
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Diversity in Structure and Function of the Ets Family PNT Domains.
J.Mol.Biol., 342, 2004
1EF4
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BU of 1ef4 by Molmil
SOLUTION STRUCTURE OF THE ESSENTIAL RNA POLYMERASE SUBUNIT RPB10 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor: DNA-DIRECTED RNA POLYMERASE, ZINC ION
Authors:Mackereth, C.D, Arrowsmith, C.H, Edwards, A.M, Mcintosh, L.P, Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-02-07
Release date:2000-06-14
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.
Proc.Natl.Acad.Sci.USA, 97, 2000
6SO9
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BU of 6so9 by Molmil
Mouse RBM20 RRM domain in complex with AUCUUA RNA
Descriptor: AUCUUA, RNA-binding protein 20
Authors:Mackereth, C.D, Upadhyay, S.K.
Deposit date:2019-08-29
Release date:2019-11-06
Last modified:2020-05-13
Method:SOLUTION NMR
Cite:Structural basis of UCUU RNA motif recognition by splicing factor RBM20.
Nucleic Acids Res., 48, 2020
6SOE
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BU of 6soe by Molmil
Mouse RBM20 RRM domain
Descriptor: RNA-binding protein 20
Authors:Mackereth, C.D, Upadhyay, S.K.
Deposit date:2019-08-29
Release date:2019-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis of UCUU RNA motif recognition by splicing factor RBM20.
Nucleic Acids Res., 48, 2020
6DG0
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BU of 6dg0 by Molmil
MEC-8 C-terminal RRM domain bound to AGCACA
Descriptor: DNA (5'-D(*AP*GP*CP*AP*CP*A)-3'), Mec-8 protein
Authors:Mackereth, C.D, Soufari, H.
Deposit date:2018-05-16
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.457 Å)
Cite:Structure of MEC-8 RRM2 in complex with AGCACA
To Be Published
7QUU
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BU of 7quu by Molmil
Red1-Iss10 complex
Descriptor: NURS complex subunit red1, Uncharacterized protein C7D4.14c
Authors:Mackereth, C.D, Kadlec, J, Laroussi, H.
Deposit date:2022-01-18
Release date:2022-09-07
Last modified:2022-11-16
Method:SOLUTION NMR
Cite:Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Nat Commun, 13, 2022
6RQS
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BU of 6rqs by Molmil
RW16 peptide
Descriptor: ARG-ARG-TRP-ARG-ARG-TRP-TRP-ARG-ARG-TRP-TRP-ARG-ARG-TRP-ARG-ARG
Authors:Jobin, M.-L, Grelard, A, Alves, I, Mackereth, C.D.
Deposit date:2019-05-16
Release date:2019-10-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.
Int J Mol Sci, 20, 2019
1ZZP
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BU of 1zzp by Molmil
Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl
Descriptor: Proto-oncogene tyrosine-protein kinase ABL1
Authors:Hantschel, O, Wiesner, S, Guttler, T, Mackereth, C.D, Rix, L.L.R, Mikes, Z, Dehne, J, Gorlich, D, Sattler, M, Superti-Furga, G.
Deposit date:2005-06-14
Release date:2005-08-30
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-Abl.
Mol.Cell, 19, 2005
5BJR
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BU of 5bjr by Molmil
Crystal structure of the N-terminal RRM domain from MEC-8
Descriptor: AMMONIUM ION, Mec-8 protein
Authors:Soufari, H, Mackereth, C.D.
Deposit date:2016-10-22
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
RNA, 23, 2017
5TKZ
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BU of 5tkz by Molmil
MEC-8 N-terminal RRM bound to tandem GCAC ligand
Descriptor: DNA (5'-D(*AP*GP*CP*AP*CP*AP*TP*TP*TP*TP*TP*TP*TP*TP*AP*GP*CP*AP*CP*A)-3'), Mec-8 protein
Authors:Soufari, H, Mackereth, C.D.
Deposit date:2016-10-10
Release date:2017-01-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
RNA, 23, 2017
2XC7
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BU of 2xc7 by Molmil
Solution Structure of PHAX-RBD in complex with ssRNA
Descriptor: 5'-(AP*UP*CP*GP)-3', PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN
Authors:Mourao, A, Mackereth, C.D, Varrot, A, Cusack, S, Sattler, M.
Deposit date:2010-04-18
Release date:2010-04-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and RNA Recognition by the Snrna and Snorna Transport Factor Phax.
RNA, 16, 2010
4CIO
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BU of 4cio by Molmil
RRM domain from C. elegans SUP-12 bound to GGUGUGC RNA
Descriptor: 5'-R(*GP*GP*UP*GP*UP*GP*CP)-3', PROTEIN SUP-12, ISOFORM A
Authors:Amrane, S, Mackereth, C.D.
Deposit date:2013-12-12
Release date:2014-09-03
Last modified:2014-09-17
Method:SOLUTION NMR
Cite:Backbone-Independent Nucleic Acid Binding by Splicing Factor Sup-12 Reveals Key Aspects of Molecular Recognition
Nat.Commun., 5, 2014
4CH1
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BU of 4ch1 by Molmil
RRM domain from C. elegans SUP-12 bound to GGTGTGC DNA
Descriptor: GGTGTGC, PROTEIN SUP-12, ISOFORM B
Authors:Amrane, S, Mackereth, C.D.
Deposit date:2013-11-28
Release date:2014-09-03
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:Backbone-Independent Nucleic Acid Binding by Splicing Factor Sup-12 Reveals Key Aspects of Molecular Recognition
Nat.Commun., 5, 2014
4CH0
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BU of 4ch0 by Molmil
RRM domain from C. elegans SUP-12
Descriptor: PROTEIN SUP-12, ISOFORM B
Authors:Amrane, S, Mackereth, C.D.
Deposit date:2013-11-27
Release date:2014-09-03
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Backbone-Independent Nucleic Acid Binding by Splicing Factor Sup-12 Reveals Key Aspects of Molecular Recognition
Nat.Commun., 5, 2014
2JUO
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BU of 2juo by Molmil
GABPa OST domain
Descriptor: GA-binding protein alpha chain
Authors:Kang, H, Nelson, M.L, Mackereth, C.D, Schaerpf, M, Graves, B.J, McIntosh, L.P.
Deposit date:2007-08-31
Release date:2008-04-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha
J.Mol.Biol., 377, 2008
2L9B
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BU of 2l9b by Molmil
Heterodimer between Rna14p monkeytail domain and Rna15p hinge domain of the yeast CF IA complex
Descriptor: mRNA 3'-end-processing protein RNA14, mRNA 3'-end-processing protein RNA15
Authors:Moreno-Morcillo, M, Minvielle-Sebastia, L, Fribourg, S, Mackereth, C.D.
Deposit date:2011-02-07
Release date:2011-04-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Locked Tether Formation by Cooperative Folding of Rna14p Monkeytail and Rna15p Hinge Domains in the Yeast CF IA Complex.
Structure, 19, 2011
8B7T
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BU of 8b7t by Molmil
CPSF73 CTD3
Descriptor: CPSF73
Authors:Thore, S, Mackereth, C.
Deposit date:2022-10-03
Release date:2023-05-03
Last modified:2023-12-06
Method:SOLUTION NMR
Cite:Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin.
Open Biology, 13, 2023
8BA1
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BU of 8ba1 by Molmil
CTD12-CTD12 heterodimer from CPSF73 and CPSF100
Descriptor: Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 3
Authors:Thore, S, Mackereth, C.
Deposit date:2022-10-10
Release date:2023-05-03
Last modified:2023-12-06
Method:SOLUTION NMR
Cite:Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin.
Open Biology, 13, 2023
6HZX
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BU of 6hzx by Molmil
Protein-aromatic foldamer complex crystal structure
Descriptor: 2-(8-azanyl-2-methanoyl-quinolin-4-yl)ethanoic acid, 6-(aminomethyl)pyridine-2-carboxylic acid, 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, ...
Authors:Post, S, Langlois d'Estaintot, B, Fischer, L, Granier, T, Huc, I.
Deposit date:2018-10-24
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas.
Chemistry, 25, 2019
5M9Z
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BU of 5m9z by Molmil
Second zinc-binding domain from yeast Pcf11
Descriptor: Protein PCF11, ZINC ION
Authors:Mackereth, C.
Deposit date:2016-11-02
Release date:2017-08-02
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing.
Nucleic Acids Res., 45, 2017
6Q9T
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BU of 6q9t by Molmil
Protein-aromatic foldamer complex crystal structure
Descriptor: 2-(8-azanyl-2-methanoyl-quinolin-4-yl)ethanoic acid, 6-(aminomethyl)pyridine-2-carboxylic acid, 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, ...
Authors:Post, S, Langlois d'Estaintot, B, Fischer, L, Granier, T, Huc, I.
Deposit date:2018-12-18
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure Elucidation of Helical Aromatic Foldamer-Protein Complexes with Large Contact Surface Areas.
Chemistry, 25, 2019
4BF8
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BU of 4bf8 by Molmil
Fpr4 PPI domain
Descriptor: FPR4
Authors:Monneau, Y, Mackereth, C.
Deposit date:2013-03-15
Release date:2013-07-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure and Activity of the Peptidyl-Prolyl Isomerase Domain from the Histone Chaperone Fpr4 Towards Histone H3 Proline Isomerization
J.Biol.Chem., 288, 2013

 

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