Author results

5CP6
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NUCLEOSOME CORE PARTICLE WITH ADDUCTS FROM THE ANTICANCER COMPOUND, [(ETA6-5,8,9,10-TETRAHYDROANTHRACENE)RU(ETHYLENEDIAMINE)CL][PF6]
分子名称:DNA (145-MER), Histone H3.2, Histone H4, ...
著者Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
登録日2015-07-21
公開日2016-06-01
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode.
Angew.Chem.Int.Ed.Engl., 55, 2016
5CHO
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CRYSTAL STRUCTURE OF BORF, THE FLAVIN REDUCTASE COMPONENT OF A BACTERIAL TWO-COMPONENT TRYPTOPHAN HALOGENASE
分子名称:Flavin reductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Ma, Z., Bellizzi, J.
登録日2015-07-10
公開日2016-06-29
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Crystal Structure of BorF, the Flavin Reductase Component of a Bacterial Two-Component Tryptophan Halogenase
To be published
5XF3
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (R,R-CONFIGURATION)
分子名称:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
著者Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
登録日2017-04-07
公開日2017-10-11
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF4
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (S,S-CONFIGURATION)
分子名称:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
著者Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
登録日2017-04-07
公開日2017-10-11
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF5
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (R,S-CONFIGURATION)
分子名称:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
著者Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
登録日2017-04-07
公開日2017-10-11
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF6
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING AN ETHYLENEDIAMINE LINKER
分子名称:Histone H3.2, Histone H4, Histone H2A, ...
著者Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
登録日2017-04-07
公開日2017-10-11
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5DNN
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NUCLEOSOME CORE PARTICLE CONTAINING ADDUCTS OF GOLD(I)-TRIETHYLPHOSPHANE AND RUTHENIUM(II)-TOLUENE PTA COMPLEXES
分子名称:Histone H3.2, Histone H4, Histone H2A, ...
著者Adhireksan, Z., Ma, Z., Davey, C.A.
登録日2015-09-10
公開日2016-09-14
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8, 2017
1U3C
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA
分子名称:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
著者Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
登録日2004-07-21
公開日2004-08-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1U3D
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA WITH AMPPNP BOUND
分子名称:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
著者Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
登録日2004-07-21
公開日2004-08-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZG1
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NARL COMPLEXED TO NIRB PROMOTER NON-PALINDROMIC TAIL-TO-TAIL DNA SITE
分子名称:5'-D(*CP*GP*TP*AP*CP*TP*CP*CP*TP*TP*AP*AP*TP*GP*GP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*TP*AP*CP*CP*CP*AP*TP*TP*AP*AP*GP*GP*AP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, ...
著者Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
登録日2005-04-20
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
1ZG5
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NARL COMPLEXED TO NARG-89 PROMOTER PALINDROMIC TAIL-TO-TAIL DNA SITE
分子名称:5'-D(*CP*GP*TP*AP*CP*CP*CP*CP*TP*AP*TP*AP*GP*GP*GP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, SULFATE ION
著者Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
登録日2005-04-20
公開日2005-11-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
4GGG
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CRYSTAL STRUCTURE OF V66A/L68V CZRA IN THE ZN(II)BOUND STATE.
分子名称:Repressor protein, ZINC ION, CHLORIDE ION
著者Campanello, G.C., Ma, Z., Grossoehme, N.E., Chakrovorty, D.K., Guerra, A.J., Ye, Y., Dann III, C.E., Merz Jr., K.M., Giedroc, D.P.
登録日2012-08-06
公開日2013-02-06
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.
J.Mol.Biol., 425, 2013
5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-09
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5W3D
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THE STRUCTURE OF KINESIN-14 WILD-TYPE NCD-ADP DIMER
分子名称:Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
著者Park, H.W., Ma, Z., Chacko, J., Jiang, S.M., Robinson, R.C., Endow, S.A.
登録日2017-06-07
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
3UIV
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HUMAN SERUM ALBUMIN-MYRISTATE-AMANTADINE HYDROCHLORIDE COMPLEX
分子名称:Serum albumin, MYRISTIC ACID, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
著者Yang, F., Ma, Z., Ma, L., Yang, G.
登録日2011-11-06
公開日2012-11-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of the drug-binding specificity of human serum albumin
TO BE PUBLISHED
4M1P
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CRYSTAL STRUCTURE OF THE COPPER-SENSING REPRESSOR CSOR WITH CU(I) FROM GEOBACILLUS THERMODENITRIFICANS NG80-2
分子名称:Copper-sensitive operon repressor (CsoR), COPPER (I) ION, SODIUM ION
著者Chang, F., Dann III, C.E., Giedroc, D.P.
登録日2013-08-03
公開日2014-05-21
最終更新日2014-10-08
実験手法X-RAY DIFFRACTION (2.564 Å)
主引用文献Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR).
J.Biol.Chem., 289, 2014
3QJ8
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE
分子名称:Fatty-acid amide hydrolase 1
著者Min, X., Walker, N.P.C., Wang, Z.
登録日2011-01-28
公開日2011-04-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QJ9
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
分子名称:Fatty-acid amide hydrolase 1, 1-{(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one, 1,2-ETHANEDIOL, ...
著者Min, X., Walker, N.P.C., Wang, Z.
登録日2011-01-28
公開日2011-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QK5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
分子名称:Fatty-acid amide hydrolase 1, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, ...
著者Min, X., Walker, N.P.C., Wang, Z.
登録日2011-01-31
公開日2011-04-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3QKV
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE COMPOUND
分子名称:Fatty-acid amide hydrolase 1, (6-bromo-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidin]-1'-yl)methanol
著者Min, X., Walker, N.P.C., Wang, Z.
登録日2011-02-01
公開日2011-04-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
5DNM
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NUCLEOSOME CORE PARTICLE CONTAINING ADDUCTS OF RUTHENIUM(II)-TOLUENE PTA COMPLEX
分子名称:Histone H3.2, Histone H4, Histone H2A, ...
著者Adhireksan, Z., Muhammad, R., Davey, C.A.
登録日2015-09-10
公開日2016-09-14
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8, 2017
6NUD
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SMALL CONFORMATION OF SSRNA-BOUND CRISPR_CSM COMPLEX
分子名称:CRISPR system Cms protein Csm2, crRNA, CRISPR type III-associated RAMP protein Csm4, ...
著者Zhang, K., Pintilie, G., Li, S., Zhu, Y., Chiu, W., Huang, Z.
登録日2019-01-31
公開日2019-03-13
最終更新日2019-04-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019
6NUE
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SMALL CONFORMATION OF APO CRISPR_CSM COMPLEX
分子名称:CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), CRISPR system Cms protein Csm2, CRISPR type III-associated RAMP protein Csm3, ...
著者Zhang, K., Pintilie, G., Li, S., Zhu, Y., Chiu, W., Huang, Z.
登録日2019-01-31
公開日2019-03-13
最終更新日2019-04-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Cell Res., 29, 2019
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