Author results

1DFJ
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RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A
Descriptor:RIBONUCLEASE A, RIBONUCLEASE INHIBITOR, SULFATE ION
Authors:Kobe, B., Deisenhofer, J.
Deposit date:1996-06-29
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural basis of the interactions between leucine-rich repeats and protein ligands.
Nature, 374, 1995
1U3C
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1U3D
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA WITH AMPPNP BOUND
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZG1
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NARL COMPLEXED TO NIRB PROMOTER NON-PALINDROMIC TAIL-TO-TAIL DNA SITE
Descriptor:5'-D(*CP*GP*TP*AP*CP*TP*CP*CP*TP*TP*AP*AP*TP*GP*GP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*TP*AP*CP*CP*CP*AP*TP*TP*AP*AP*GP*GP*AP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, ...
Authors:Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
Deposit date:2005-04-20
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
1ZG5
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NARL COMPLEXED TO NARG-89 PROMOTER PALINDROMIC TAIL-TO-TAIL DNA SITE
Descriptor:5'-D(*CP*GP*TP*AP*CP*CP*CP*CP*TP*AP*TP*AP*GP*GP*GP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, SULFATE ION
Authors:Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
Deposit date:2005-04-20
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
2HH7
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CRYSTAL STRUCTURE OF CU(I) BOUND CSOR FROM MYCOBACTERIUM TUBERCULOSIS.
Descriptor:Hypothetical protein CsoR, COPPER (I) ION
Authors:Sacchettini, J.C., Ramesh, A.
Deposit date:2006-06-27
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nat.Chem.Biol., 3, 2007
3CH6
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CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH (3,3-DIMETHYLPIPERIDIN-1-YL)(6-(3-FLUORO-4-METHYLPHENYL)PYRIDIN-2-YL)METHANONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone
Authors:Sheriff, S.
Deposit date:2008-03-07
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
Bioorg.Med.Chem.Lett., 18, 2008
3QK5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3QJ8
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE
Descriptor:Fatty-acid amide hydrolase 1
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QJ9
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, 1-{(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QKV
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE COMPOUND
Descriptor:Fatty-acid amide hydrolase 1, (6-bromo-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidin]-1'-yl)methanol
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-02-01
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3R60
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STRUCTURE OF THE MNTR FE2+ COMPLEX
Descriptor:Transcriptional regulator mntR, FE (II) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glasfeld, A., Brophy, M.B., Kliegman, J.I., Griner, S.L., Nix, J.C.
Deposit date:2011-03-20
Release date:2012-04-11
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
3R61
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STRUCTURE OF THE MNTR CO2+ COMPLEX
Descriptor:Transcriptional regulator mntR, COBALT (II) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Glasfeld, A., Brophy, M.B., Kliegman, J.I., Griner, S.L., Nix, J.C.
Deposit date:2011-03-20
Release date:2012-04-11
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.9002 Å)
Cite:Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
3UIV
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HUMAN SERUM ALBUMIN-MYRISTATE-AMANTADINE HYDROCHLORIDE COMPLEX
Descriptor:Serum albumin, MYRISTIC ACID, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
Authors:Yang, F., Ma, Z., Ma, L., Yang, G.
Deposit date:2011-11-06
Release date:2012-11-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of the drug-binding specificity of human serum albumin
TO BE PUBLISHED
4HV5
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STRUCTURE OF THE MNTR FE2+ COMPLEX WITH E SITE METAL BINDING
Descriptor:Transcriptional regulator MntR, FE (II) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Glasfeld, A., Brophy, M.B., Kliegman, J.I., Griner, S.L.
Deposit date:2012-11-05
Release date:2012-11-14
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Roles of the A and C sites in the manganese-specific activation of MntR.
Biochemistry, 52, 2013
4HV6
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STRUCTURE OF MNTR H77A MUTANT IN APO- AND MN-BOUND FORMS
Descriptor:Transcriptional regulator MntR, MANGANESE (II) ION, MAGNESIUM ION
Authors:Glasfeld, A., Grauer-Gray, K., McGuire, A.
Deposit date:2012-11-05
Release date:2012-11-21
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Roles of the A and C sites in the manganese-specific activation of MntR.
Biochemistry, 52, 2013
4HX4
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STRUCTURE OF MNTR MUTANT E11K COMPLEXED WITH MN2+
Descriptor:TRANSCRIPTIONAL REGULATOR MNTR, MANGANESE (II) ION
Authors:Glasfeld, A., McGuire, A.
Deposit date:2012-11-09
Release date:2012-11-21
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
4HX7
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STRUCTURE OF MNTR E11K MUTANT COMPLEXED WITH CD2+
Descriptor:Transcriptional regulator MntR, CADMIUM ION
Authors:Glasfeld, A., Cuthbert, B.J.
Deposit date:2012-11-09
Release date:2012-11-21
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
4HX8
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STRUCTURE OF METAL-FREE MNTR MUTANT E11K
Descriptor:Transcriptional regulator MntR
Authors:Glasfeld, A., Mcguire, A.
Deposit date:2012-11-09
Release date:2012-11-21
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Roles of the A and C Sites in the Manganese-Specific Activation of MntR.
Biochemistry, 52, 2013
4GGG
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CRYSTAL STRUCTURE OF V66A/L68V CZRA IN THE ZN(II)BOUND STATE.
Descriptor:Repressor protein, ZINC ION, CHLORIDE ION
Authors:Campanello, G.C., Ma, Z., Grossoehme, N.E., Chakrovorty, D.K., Guerra, A.J., Ye, Y., Dann III, C.E., Merz Jr., K.M., Giedroc, D.P.
Deposit date:2012-08-06
Release date:2013-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.
J.Mol.Biol., 425, 2013
4I7H
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STRUCTURAL BASIS FOR PEROXIDE SENSING AND GENE REGULATION BY PERR FROM STREPTOCOCCUS PYOGENES
Descriptor:peroxide stress sensing regulator, NICKEL (II) ION, ZINC ION
Authors:Kumaraswami, M.
Deposit date:2012-11-30
Release date:2013-05-08
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Peroxide Stress Regulator from Streptococcus pyogenes Provides Functional Insights into the Mechanism of Oxidative Stress Sensing.
J.Biol.Chem., 288, 2013
4KW5
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M. TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA1
Descriptor:Oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate, ...
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2013-05-23
Release date:2013-07-10
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4M1P
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CRYSTAL STRUCTURE OF THE COPPER-SENSING REPRESSOR CSOR WITH CU(I) FROM GEOBACILLUS THERMODENITRIFICANS NG80-2
Descriptor:Copper-sensitive operon repressor (CsoR), COPPER (I) ION, SODIUM ION
Authors:Chang, F., Dann III, C.E., Giedroc, D.P.
Deposit date:2013-08-03
Release date:2014-05-21
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.564 Å)
Cite:Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR).
J.Biol.Chem., 289, 2014
4OA7
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CRYSTAL STRUCTURE OF TANKYRASE1 IN COMPLEX WITH IWR1
Descriptor:Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide
Authors:Zhang, X., He, H.
Deposit date:2014-01-03
Release date:2015-01-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
4OFB
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CRYSTAL STRUCTURE OF HUMAN BRCA1 BRCT IN COMPLEX WITH NONPHOSPHOPEPTIDE INHIBITOR
Descriptor:Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
Authors:Sun, L., Edwards, R.A., Glover, J.N.M.
Deposit date:2014-01-14
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
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