Author results

6JCN
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YEAST DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1
Descriptor:Dehydrodolichyl diphosphate synthase complex subunit NUS1, SULFATE ION
Authors:Ko, T.-P., Ma, J., Liu, W., Chen, C.-C., Guo, R.-T.
Deposit date:2019-01-29
Release date:2019-06-19
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.
Biochem.Biophys.Res.Commun., 515, 2019
6JCJ
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STRUCTURE OF CROLIBULIN IN COMPLEX WITH TUBULIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, Z., Yang, J.
Deposit date:2019-01-29
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 511, 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6F02
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CRYSTAL STRUCTURE OF HUMAN GLYCOSYLATED KALLISTATIN AT 3.0 ANGSTROM RESOLUTION
Descriptor:Kallistatin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Zhou, A., Ma, L.
Deposit date:2017-11-17
Release date:2018-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human Kallistatin
To Be Published
6F4U
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CRYSTAL STRUCTURE OF REACTIVE LOOP CLEAVED KALLISTATIN AT 1.9 ANGSTROM RESOLUTION
Descriptor:Kallistatin, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Zhou, A., Wei, Z., Lin, F.
Deposit date:2017-11-30
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Kallistatin
To Be Published
6F4V
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CRYSTAL STRUCTURE OF CLEAVED KALLISTATIN COMPLEXED WITH HEPARIN AT 1.8 ANGSTROM RESOLUTION
Descriptor:Kallistatin, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Zhou, A., Wei, Z.
Deposit date:2017-11-30
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human Kallistatin
To Be Published
5WLX
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SOLUTION STRUCTURE OF KAPPA-THERAPHOTOXIN-AA1A
Descriptor:Kappa-theraphotoxin-Aa1a
Authors:Chin, Y.K.Y., Ma, L., King, G.F.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2019-02-27
Method:SOLUTION NMR
Cite:Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.
Biochem. Pharmacol., 158, 2018
5WP2
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1.44 ANGSTROM CRYSTAL STRUCTURE OF CYP121 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH SUBSTRATE AND CN
Descriptor:Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, ...
Authors:Fielding, A., Dornevil, K., Liu, A.
Deposit date:2017-08-03
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.439 Å)
Cite:Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature.
J. Am. Chem. Soc., 139, 2017
5XMF
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CRYSTAL STRUCTURE OF FELINE MHC CLASS I FOR 2,1 ANGSTROM
Descriptor:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
Authors:Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
Deposit date:2017-05-15
Release date:2017-12-13
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
5XMM
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FLA-E*01801-167W/S
Descriptor:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
Authors:Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
Deposit date:2017-05-15
Release date:2017-12-13
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Yu, Y., Chen, Q.
Deposit date:2017-05-11
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5JHG
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE HUMAN RHOA AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL
Authors:Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
5JHH
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN THE HUMAN RHOA, ITS INHIBITOR AND THE DH/PH DOMAIN OF HUMAN ARHGEF11
Descriptor:Rho guanine nucleotide exchange factor 11, Transforming protein RhoA, GLYCEROL, ...
Authors:Lv, Z., Wang, R., Ma, L., Miao, Q., Wu, J., Yan, Z., Li, J., Miao, L., Wang, F.
Deposit date:2016-04-21
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF
To Be Published
5EZ6
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CRYSTALLIZATION AND PRELIMINARY X-RAY CRYSTALLOGRAPHIC ANALYSIS OF A SMALL GTPASE RHOA
Descriptor:Transforming protein RhoA, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Yan, Z., Ma, S., Zhang, Y., Ma, L., Wang, F., Li, J., Miao, L.
Deposit date:2015-11-26
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA
To Be Published
5INW
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STRUCTURE OF REACTION LOOP CLEAVED LAMPREY ANGIOTENSINOGEN
Descriptor:Putative angiotensinogen, C-terminal peptide of Putative angiotensinogen, SULFATE ION
Authors:Wei, H., Zhou, A.
Deposit date:2016-03-08
Release date:2016-10-05
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
5LMZ
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FLUORINASE FROM STREPTOMYCES SP. MA37
Descriptor:Fluorinase, 1-DEAZA-ADENOSINE, CHLORIDE ION, ...
Authors:Mann, G., O'Hagan, D., Naismith, J.H., Bandaranayaka, N.
Deposit date:2016-08-02
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining.
Chembiochem, 15, 2014
5DIL
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF THE NS1 PROTEIN FROM INFLUENZA VIRUS B
Descriptor:Non-structural protein 1, IODIDE ION
Authors:Guan, R., Hamilton, K., Ma, L., Montelione, G.T.
Deposit date:2015-09-01
Release date:2016-08-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure, 24, 2016
5JP2
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FCHO1 MU HOMOLOGY DOMAIN (DANIO RERIO) WITH BOUND EPS15 PEPTIDE
Descriptor:Epidermal growth factor receptor substrate 15, F-BAR domain only protein 1, ZINC ION
Authors:McCoy, A.J., Wrobel, A., Owen, D.J.
Deposit date:2016-05-03
Release date:2016-06-08
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Transient Fcho1/2Eps15/RAP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.
Dev.Cell, 37, 2016
4Y2I
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GOLD ION BOUND TO GOLB
Descriptor:Putative metal-binding transport protein, GOLD ION
Authors:Wei, W., Wang, F., Ma, L., Zhao, J.
Deposit date:2015-02-10
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
4Y2K
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REDUCED FORM OF APO-GOLB
Descriptor:Putative metal-binding transport protein
Authors:Wei, W., Wang, F., Ma, L., Zhao, J.
Deposit date:2015-02-10
Release date:2016-02-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
4QXM
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CRYSTAL STRUCTURE OF THE INHA:GSK_SB713 COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-(2-chloro-4-fluorobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide
Authors:Gulten, G., Sacchettini, J.C.
Deposit date:2014-07-21
Release date:2015-07-22
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.
Chemmedchem, 11, 2016
4ZT0
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CRYSTAL STRUCTURE OF CATALYTICALLY-ACTIVE STREPTOCOCCUS PYOGENES CAS9 IN COMPLEX WITH SINGLE-GUIDE RNA AT 2.9 ANGSTROM RESOLUTION
Descriptor:CRISPR-associated endonuclease Cas9, single-guide RNA
Authors:Jiang, F., Doudna, J.A.
Deposit date:2015-05-14
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Cas9-guide RNA complex preorganized for target DNA recognition.
Science, 348, 2015