Author results

6OVC
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HMCL1 INHIBITOR COMPLEX
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (2S)-N-(benzylsulfonyl)-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
Authors:Poppe, L.
Deposit date:2019-05-07
Release date:2019-05-22
Method:SOLUTION NMR
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6JYV
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STRUCTURE OF AN ISOPENICILLIN N SYNTHASE FROM PSEUDOMONAS AERUGINOSA PAO1
Descriptor:Probable iron/ascorbate oxidoreductase, SODIUM ION
Authors:Hao, Z., Che, S., Wang, R., Liu, R., Zhang, Q., Bartlam, M.
Deposit date:2019-04-28
Release date:2019-05-22
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1
Biochem.Biophys.Res.Commun., 2019
6OQQ
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LEGIONELLA PNEUMOPHILA SIDJ/SACCHAROMYCES CEREVISIAE CALMODULIN COMPLEX
Descriptor:Legionella pneumophila SidJ, Calmodulin, ADENOSINE MONOPHOSPHATE, ...
Authors:Tomchick, D.R., Tagliabracci, V.S., Black, M., Osinski, A.
Deposit date:2019-04-28
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
Science, 2019
6OQB
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CO-CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,11E,15R)-6'-chloro-15-ethyl-10-hydroxy-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6OQD
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CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 8
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,11,12,13,14,15-dodecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6OQN
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CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 7
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S)-5'-chloro-2',3',7,8,9,10,11,12-octahydro-3H,5H,14H-spiro[1,19-etheno-16lambda~6~-[1,4]oxazepino[3,4-i][1,4,5,10]oxathiadiazacyclohexadecine-4,1'-indene]-16,16,18(15H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6ON6
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CRYSTAL STRUCTURE OF THE RIG-5 IG1 HOMODIMER
Descriptor:NeuRonal IgCAM-5, GLYCEROL, N-ACETYL-D-GLUCOSAMINE
Authors:Cheng, S., Kurleto, J.D., Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 2019
6ON9
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CRYSTAL STRUCTURE OF THE ZIG-8-RIG-5 IG1-IG1 HETERODIMER, TETRAGONAL FORM
Descriptor:Zwei Ig domain protein zig-8, NeuRonal IgCAM-5, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Cheng, S., Kurleto, J.D., Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 2019
6ONB
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CRYSTAL STRUCTURE OF THE ZIG-8-RIG-5 IG1-IG1 HETERODIMER, MONOCLINIC FORM
Descriptor:Zwei Ig domain protein zig-8, NeuRonal IgCAM-5, SULFATE ION, ...
Authors:Cheng, S., Kurleto, J.D., Ozkan, E.
Deposit date:2019-04-20
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Proc.Natl.Acad.Sci.USA, 2019
6OMN
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GLYCOSYLATED BMP2 HOMODIMER
Descriptor:Bone morphogenetic protein 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Juo, Z.S., Seeherman, H.
Deposit date:2019-04-19
Release date:2019-05-08
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
6OMO
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HUMAN BMP6 HOMODIMER
Descriptor:Bone morphogenetic protein 6, ISOPROPYL ALCOHOL, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Juo, Z.S., Seeherman, H.
Deposit date:2019-04-19
Release date:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
6ON2
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LON PROTEASE FROM YERSINIA PESTIS WITH Y2853 SUBSTRATE
Descriptor:ATP-dependent protease La, Bound Y2853 Substrate, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shin, M., Asmita, A., Puchades, C., Adjei, E., Wiseman, R.L., Karzai, A.W., Lander, G.C.
Deposit date:2019-04-19
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Distinct Structural Features of the Lon Protease Drive Conserved Hand-over-Hand Substrate Translocation
To Be Published
6OML
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HUMAN BMP CHIMERA BV261
Descriptor:Bone morphogenetic protein 2 and Bone morphogenetic protein 6, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Seeherman, H., Juo, Z.S.
Deposit date:2019-04-18
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
6RGL
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE (AFP) BASEPLATE IN CONTRACTED STATE
Descriptor:Afp2, Afp3, Afp4
Authors:Desfosses, A.
Deposit date:2019-04-16
Release date:2019-04-24
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Atomic structures of an entire contractile injection system in both the extended and contracted states
To Be Published
6RBN
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE (AFP) HELICAL SHEATH-TUBE COMPLEX IN EXTENDED STATE
Descriptor:Afp1, Afp2, Afp3
Authors:Desfosses, A.
Deposit date:2019-04-11
Release date:2019-04-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Atomic structures of an entire contractile injection system in both the extended and contracted states
To Be Published
6RC8
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE (AFP) HELICAL SHEATH IN CONTRACTED STATE
Descriptor:Afp2, Afp3
Authors:Desfosses, A.
Deposit date:2019-04-11
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of an entire contractile injection system in both the extended and contracted states
To Be Published
6RBK
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE (AFP) BASEPLATE IN EXTENDED STATE, 3-FOLD SYMMETRISED
Descriptor:Afp7, Afp8
Authors:Desfosses, A.
Deposit date:2019-04-10
Release date:2019-04-24
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of an entire contractile injection system in both the extended and contracted states
To Be Published
6RAV
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COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID
Descriptor:Complement factor B, SULFATE ION, 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, ...
Authors:Adams, C.M., Sellner, H., Ehara, T., Mac Sweeney, A., Crowley, M., Anderson, K., Karki, R., Mainolfi, N., Valeur, E., Sirockin, F., Gerhartz, B., Erbel, P., Hughes, N., Smith, T.M., Cumin, F., Argikar, U., Mogi, M., Sedrani, R., Wiesmann, C., Jaffee, B., Maibaum, J., Flohr, S., Harrison, R., Eder, J.
Deposit date:2019-04-08
Release date:2019-04-17
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
To be published
6RAP
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE CAP (AFP TUBE TERMINATING CAP)
Descriptor:Afp1, Afp2, Afp3, ...
Authors:Desfosses, A.
Deposit date:2019-04-07
Release date:2019-04-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Atomic structures of an entire contractile injection system in both the extended and contracted states
To Be Published
6RAO
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CRYO-EM STRUCTURE OF THE ANTI-FEEDING PROPHAGE (AFP) BASEPLATE, 6-FOLD SYMMETRISED
Descriptor:Afp1, Afp2, Afp3, ...
Authors:Desfosses, A.
Deposit date:2019-04-06
Release date:2019-04-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of the anti-feeding prophage (AFP) baseplate, 6-fold symmetrised
To Be Published
6RAA
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CLK1 KINASE DOMAIN WITH BOUND IMIDAZOPYRIDIN INHIBITOR TP003
Descriptor:Dual specificity protein kinase CLK1, 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide, 1,2-ETHANEDIOL
Authors:Schroeder, M., Arrowsmith, C., Knapp, S., Bountra, C., Edwards, A., Structural Genomics Consortium (SGC)
Deposit date:2019-04-05
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:CLK1 Kinase domain with bound imidazopyridin inhibitor TP003
To Be Published
6OGJ
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6OGK
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6R8K
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COMPLEX OF RICE BLAST (MAGNAPORTHE ORYZAE) EFFECTOR PROTEIN AVR-PIKD WITH AN ENGINEERED HMA DOMAIN OF PIKP-1 FROM RICE (ORYZA SATIVA)
Descriptor:NBS-LRR class disease resistance protein Pikh-1, AVR-Pik protein
Authors:De la Concepcion, J.C., Franceschetti, M., Banfield, M.J.
Deposit date:2019-04-02
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Protein engineering expands the effector recognition profile of a rice NLR immune receptor
Biorxiv, 2019
6R8M
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COMPLEX OF RICE BLAST (MAGNAPORTHE ORYZAE) EFFECTOR PROTEIN AVR-PIKE WITH AN ENGINEERED HMA DOMAIN OF PIKP-1 FROM RICE (ORYZA SATIVA)
Descriptor:NBS-LRR class disease resistance protein Pikh-1, AVR-Pik protein, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:De la Concepcion, J.C., Franceschetti, M., Banfield, M.J.
Deposit date:2019-04-02
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Protein engineering expands the effector recognition profile of a rice NLR immune receptor
Biorxiv, 2019