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3J63
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BU of 3j63 by Molmil
Unified assembly mechanism of ASC-dependent inflammasomes
Descriptor: Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H.
Deposit date:2013-12-05
Release date:2014-03-26
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
Cell(Cambridge,Mass.), 156, 2014
3QPD
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BU of 3qpd by Molmil
Structure of Aspergillus oryzae cutinase expressed in Pichia pastoris, crystallized in the presence of Paraoxon
Descriptor: Cutinase 1
Authors:Lu, A, Gosser, Y, Montclare, J.K, Liu, Z, Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Method:X-RAY DIFFRACTION (1.571 Å)
Cite:Structure of Aspergillus oryzae cutinase expressed in Pichia pastoris, crystallized in the presence of Paraoxon
To be Published
3QPA
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BU of 3qpa by Molmil
Structure of Fusarium Solani Cutinase expressed in Pichia pastoris
Descriptor: Cutinase
Authors:Lu, A, Gosser, Y, Montclare, J.K, Liu, Z, Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Structure of Fusarium Solani Cutinase expressed in Pichia pastoris
To be Published
3QPC
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BU of 3qpc by Molmil
Structure of Fusarium Solani Cutinase expressed in Pichia pastoris, crystallized in the presence of Paraoxon
Descriptor: Cutinase
Authors:Lu, A, Gosser, Y, Montclare, J.K, Liu, Z, Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Method:X-RAY DIFFRACTION (0.978 Å)
Cite:Structure of Fusarium Solani Cutinase expressed in Pichia pastoris
To be Published
6MB2
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BU of 6mb2 by Molmil
Cryo-EM structure of the PYD filament of AIM2
Descriptor: Green fluorescent protein, Interferon-inducible protein AIM2
Authors:Lu, A, Li, Y, Wu, H.
Deposit date:2018-08-29
Release date:2018-09-05
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Cell Discov, 1, 2015
4O7Q
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BU of 4o7q by Molmil
Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions
Descriptor: Interferon-inducible protein AIM2
Authors:Lu, A, Kabaleeswaran, V, Wu, H.
Deposit date:2013-12-26
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions.
J.Mol.Biol., 426, 2014
8SMF
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BU of 8smf by Molmil
Structure of SPO1 phage Tad2 in complex with 1''-3' gcADPR
Descriptor: (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Gp34.65, MAGNESIUM ION
Authors:Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J.
Deposit date:2023-04-26
Release date:2023-11-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
8SME
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BU of 8sme by Molmil
Structure of SPO1 phage Tad2 in apo state
Descriptor: Gp34.65
Authors:Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J.
Deposit date:2023-04-26
Release date:2023-11-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
8SMG
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BU of 8smg by Molmil
Structure of SPO1 phage Tad2 in complex with 1''-2' gcADPR
Descriptor: (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Gp34.65
Authors:Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J.
Deposit date:2023-04-26
Release date:2023-11-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
8SMD
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BU of 8smd by Molmil
Structure of Clostridium botulinum prophage Tad1 in complex with 1''-3' gcADPR
Descriptor: (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, ABC transporter ATPase
Authors:Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J.
Deposit date:2023-04-26
Release date:2023-11-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phages overcome bacterial immunity via diverse anti-defence proteins.
Nature, 625, 2024
5H8O
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BU of 5h8o by Molmil
Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC
Descriptor: Apoptosis-associated speck-like protein containing a CARD, VHH nanobody
Authors:Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (4.206 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
5H8D
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BU of 5h8d by Molmil
Crystal structure of an ASC binding nanobody
Descriptor: VHH nanobody
Authors:Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
7UAV
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BU of 7uav by Molmil
Structure of Clostridium botulinum prophage Tad1 in apo state
Descriptor: ABC transporter ATPase
Authors:Lu, A, Leavitt, A, Yirmiya, E, Amitai, G, Garb, J, Morehouse, B.R, Hobbs, S.J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-03-14
Release date:2022-10-05
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.
Nature, 611, 2022
7UAW
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BU of 7uaw by Molmil
Structure of Clostridium botulinum prophage Tad1 in complex with 1''-2' gcADPR
Descriptor: (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, ABC transporter ATPase
Authors:Lu, A, Leavitt, A, Yirmiya, E, Amitai, G, Garb, J, Morehouse, B.R, Hobbs, S.J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-03-14
Release date:2022-10-05
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.
Nature, 611, 2022
5L08
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BU of 5l08 by Molmil
Cryo-EM structure of Casp-8 tDED filament
Descriptor: Caspase-8
Authors:Fu, T.M, Li, Y, Lu, A, Wu, H.
Deposit date:2016-07-26
Release date:2016-11-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
7T28
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BU of 7t28 by Molmil
Structure of phage Bsp38 anti-Pycsar nuclease Apyc1 in apo state
Descriptor: Putative metal-dependent hydrolase, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2021-12-03
Release date:2022-04-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7T27
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BU of 7t27 by Molmil
Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state
Descriptor: Acb1, SULFATE ION, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic acid
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2021-12-03
Release date:2022-04-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7T26
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BU of 7t26 by Molmil
Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state
Descriptor: Acb1
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2021-12-03
Release date:2022-04-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7U2S
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BU of 7u2s by Molmil
Structure of Paenibacillus xerothermodurans Apyc1 in the apo state
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
7U2R
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BU of 7u2r by Molmil
Structure of Paenibacillus sp. J14 Apyc1
Descriptor: Apyc1, ZINC ION
Authors:Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J.
Deposit date:2022-02-24
Release date:2022-04-20
Last modified:2022-06-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
Nature, 605, 2022
5JQE
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BU of 5jqe by Molmil
Crystal structure of caspase8 tDED
Descriptor: Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
Authors:Fu, T, Li, Y, Lu, A, Wu, H.
Deposit date:2016-05-04
Release date:2016-10-26
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (3.157 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
3JBL
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BU of 3jbl by Molmil
Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization
Descriptor: NLR family CARD domain-containing protein 4
Authors:Zhang, L, Chen, S, Ruan, J, Wu, J, Tong, A.B, Yin, Q, Li, Y, David, L, Lu, A, Wang, W.L, Marks, C, Ouyang, Q, Zhang, X, Mao, Y, Wu, H.
Deposit date:2015-09-05
Release date:2015-10-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
5FNA
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BU of 5fna by Molmil
Cryo-EM reconstruction of caspase-1 CARD
Descriptor: Caspase-1
Authors:Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H.
Deposit date:2015-11-11
Release date:2016-03-30
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
8B6U
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BU of 8b6u by Molmil
Mpf2Ba1 monomer
Descriptor: MAGNESIUM ION, Mpf2Ba1
Authors:Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez-Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R.
Deposit date:2022-09-27
Release date:2023-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.134 Å)
Cite:Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023
8B6W
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BU of 8b6w by Molmil
Mpf2Ba1 pore
Descriptor: MAGNESIUM ION, Mpf2Ba1
Authors:Marini, G, Poland, B, Leininger, C, Lukoyanova, N, Spielbauer, D, Barry, J, Altier, D, Lum, A, Scolaro, E, Perez Ortega, C, Yalpani, N, Sandahl, G, Mabry, T, Klever, J, Nowatzki, T, Zhao, J.Z, Sethi, A, Kassa, A, Crane, V, Lu, A, Nelson, M.E, Eswar, N, Topf, M, Saibil, H.R.
Deposit date:2022-09-27
Release date:2023-05-31
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural journey of an insecticidal protein against western corn rootworm.
Nat Commun, 14, 2023

 

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