Author results

3J63
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UNIFIED ASSEMBLY MECHANISM OF ASC-DEPENDENT INFLAMMASOMES
Descriptor:Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M., Schroder, G.F., Fitzgerald, K.A., Wu, H., Egelman, E.H.
Deposit date:2013-12-05
Release date:2014-03-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes.
Cell(Cambridge,Mass.), 156, 2014
3QPA
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STRUCTURE OF FUSARIUM SOLANI CUTINASE EXPRESSED IN PICHIA PASTORIS
Descriptor:Cutinase
Authors:Lu, A., Gosser, Y., Montclare, J.K., Liu, Z., Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Structure of Fusarium Solani Cutinase expressed in Pichia pastoris
To be Published
3QPC
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STRUCTURE OF FUSARIUM SOLANI CUTINASE EXPRESSED IN PICHIA PASTORIS, CRYSTALLIZED IN THE PRESENCE OF PARAOXON
Descriptor:Cutinase
Authors:Lu, A., Gosser, Y., Montclare, J.K., Liu, Z., Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Method:X-RAY DIFFRACTION (0.978 Å)
Cite:Structure of Fusarium Solani Cutinase expressed in Pichia pastoris
To be Published
3QPD
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STRUCTURE OF ASPERGILLUS ORYZAE CUTINASE EXPRESSED IN PICHIA PASTORIS, CRYSTALLIZED IN THE PRESENCE OF PARAOXON
Descriptor:Cutinase 1
Authors:Lu, A., Gosser, Y., Montclare, J.K., Liu, Z., Kong, X.
Deposit date:2011-02-11
Release date:2012-02-29
Method:X-RAY DIFFRACTION (1.571 Å)
Cite:Structure of Aspergillus oryzae cutinase expressed in Pichia pastoris, crystallized in the presence of Paraoxon
To be Published
4O7Q
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CRYSTAL STRUCTURE OF THE F27G AIM2 PYRIN DOMAIN MUTANT AND SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DED INTERACTIONS
Descriptor:Interferon-inducible protein AIM2
Authors:Lu, A., Kabaleeswaran, V., Wu, H.
Deposit date:2013-12-26
Release date:2014-02-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions.
J.Mol.Biol., 426, 2014
6MB2
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CRYO-EM STRUCTURE OF THE PYD FILAMENT OF AIM2
Descriptor:Interferon-inducible protein AIM2, Green fluorescent protein
Authors:Lu, A., Li, Y., Wu, H.
Deposit date:2018-08-29
Release date:2018-09-05
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.
Cell Discov, 1, 2015
5H8D
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CRYSTAL STRUCTURE OF AN ASC BINDING NANOBODY
Descriptor:VHH nanobody
Authors:Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
5H8O
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CRYSTAL STRUCTURE OF AN ASC-BINDING NANOBODY IN COMPLEX WITH THE CARD DOMAIN OF ASC
Descriptor:VHH nanobody, Apoptosis-associated speck-like protein containing a CARD
Authors:Lu, A., Schmidt, F.I., Ruan, J., Tang, C., Wu, H., Ploegh, H.L.
Deposit date:2015-12-23
Release date:2016-04-06
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (4.206 Å)
Cite:A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
3JBL
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CRYO-EM STRUCTURE OF THE ACTIVATED NAIP2/NLRC4 INFLAMMASOME REVEALS NUCLEATED POLYMERIZATION
Descriptor:NLR family CARD domain-containing protein 4
Authors:Zhang, L., Chen, S., Ruan, J., Wu, J., Tong, A.B., Yin, Q., Li, Y., David, L., Lu, A., Wang, W.L., Marks, C., Ouyang, Q., Zhang, X., Mao, Y., Wu, H.
Deposit date:2015-09-05
Release date:2015-10-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
5FNA
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CRYO-EM RECONSTRUCTION OF CASPASE-1 CARD
Descriptor:CASPASE-1
Authors:Li, Y., Lu, A., Schmidt, F.I., Yin, Q., Chen, S., Fu, T.M., Tong, A.B., Ploegh, H.L., Mao, Y., Wu, H.
Deposit date:2015-11-11
Release date:2016-03-30
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
5JQE
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CRYSTAL STRUCTURE OF CASPASE8 TDED
Descriptor:Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
Authors:Fu, T., Li, Y., Lu, A., Wu, H.
Deposit date:2016-05-04
Release date:2016-10-26
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3.157 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
5L08
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CRYO-EM STRUCTURE OF CASP-8 TDED FILAMENT
Descriptor:Caspase-8
Authors:Fu, T.M., Li, Y., Lu, A., Wu, H.
Deposit date:2016-07-26
Release date:2016-11-02
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
5I2K
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH 7-{[ETHYL(4-FLUOROPHENYL)AMINO]METHYL}-N,2-DIMETHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 19)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-02-09
Release date:2016-03-16
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5I2N
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH N-ETHYL-7-{[2-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL}-2-METHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 29)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-02-09
Release date:2016-03-16
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5KDT
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE0723
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-06-08
Release date:2016-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J. Med. Chem., 59, 2016
4L5Q
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CRYSTAL STRUCTURE OF P202 HIN1
Descriptor:Interferon-activable protein 202
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5R
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CRYSTAL STRUCTURE OF P202 HIN1 IN COMPLEX WITH 20-MER DSDNA
Descriptor:Interferon-activable protein 202, 20-mer DNA, SODIUM ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (1.873 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5S
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P202 HIN1 IN COMPLEX WITH 12-MER DSDNA
Descriptor:Interferon-activable protein 202, 12-mer DNA, SULFATE ION
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-08-14
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4L5T
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CRYSTAL STRUCTURE OF THE TETRAMERIC P202 HIN2
Descriptor:Interferon-activable protein 202
Authors:Yin, Q., Tian, Y., Wu, H.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Cell Rep, 4, 2013
4X9Z
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DIMERIC CONOTOXIN ALPHAD-GEXXA
Descriptor:alphaD-conotoxin GeXXA from the venom of Conus generalis
Authors:Xu, S., Zhang, T., Kompella, S., Adams, D., Ding, J., Wang, C.
Deposit date:2014-12-12
Release date:2015-12-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conotoxin alpha D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
Sci Rep, 5, 2015
5TP9
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH COMPOUND 2 (GNE9178)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
5TPA
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH COMPOUND 9 (GNE3500)
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
Authors:Wallweber, H.J.A., Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
6N1H
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CRYO-EM STRUCTURE OF ASC-CARD FILAMENT
Descriptor:Apoptosis-associated speck-like protein containing a CARD
Authors:Li, Y., Fu, T., Wu, H.
Deposit date:2018-11-08
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6N1I
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CRYO-EM STRUCTURE OF NLRC4-CARD FILAMENT
Descriptor:NLR family CARD domain-containing protein 4
Authors:Li, Y., Fu, T., Wu, H.
Deposit date:2018-11-08
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6NCV
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CRYO-EM STRUCTURE OF NLRP6 PYD FILAMENT
Descriptor:NACHT, LRR and PYD domains-containing protein 6
Authors:Shen, C., Fu, T.M., Wu, H.
Deposit date:2018-12-12
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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