Author results

2BWB
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CRYSTAL STRUCTURE OF THE UBA DOMAIN OF DSK2 FROM S. CEREVISIAE
Descriptor:UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWE
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THE CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE UBA AND UBL DOMAINS OF DSK2
Descriptor:DSK2
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWF
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CRYSTAL STURCTURE OF THE UBL DOMAIN OF DSK2 FROM S. CEREVISIAE
Descriptor:UBIQUITIN-LIKE PROTEIN DSK2, FORMIC ACID
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2PHK
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THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION
Descriptor:PHOSPHORYLASE KINASE, MC-PEPTIDE, MANGANESE (II) ION, ...
Authors:Lowe, E.D., Noble, M.E.M., Skamnaki, V.T., Oikonomakos, N.G., Owen, D.J., Johnson, L.N.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
EMBO J., 16, 1997
2VLE
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THE STRUCTURE OF DAIDZIN, A NATURALLY OCCURRING ANTI ALCOHOL- ADDICTION AGENT, IN COMPLEX WITH HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
Descriptor:ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL, DAIDZIN
Authors:Lowe, E.D., Gao, G.Y., Johnson, L.N., Keung, W.M.
Deposit date:2008-01-13
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase.
J.Med.Chem., 51, 2008
1H24
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CDK2/CYCLINA IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H26
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELLULAR TUMOR ANTIGEN P53
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P107
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1W98
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THE STRUCTURAL BASIS OF CDK2 ACTIVATION BY CYCLIN E
Descriptor:CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1
Authors:Lowe, E.D., Honda, R., Dubinina, E., Skamnaki, V., Cook, A., Johnson, L.N.
Deposit date:2004-10-07
Release date:2005-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles
Embo J., 24, 2005
1QL6
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THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor:PHOSPHORYLASE KINASE, ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Skamnaki, V.T., Owen, D.J., Noble, M.E.M., Lowe, E.D., Oikonomakos, N.G., Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
1GY3
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PCDK2/CYCLIN A IN COMPLEX WITH MGADP, NITRATE AND PEPTIDE SUBSTRATE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, SUBSTRATE PEPTIDE, ...
Authors:Cook, A., Lowe, E.D., Chrysina, E.D., Skamnaki, V.T., Oikonomakos, N.G., Johnson, L.N.
Deposit date:2002-04-19
Release date:2002-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism
Biochemistry, 41, 2002
1P7B
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CRYSTAL STRUCTURE OF AN INWARD RECTIFIER POTASSIUM CHANNEL
Descriptor:integral membrane channel and cytosolic domains, POTASSIUM ION
Authors:Kuo, A., Gulbis, J.M., Antcliff, J.F., Rahman, T., Lowe, E.D., Zimmer, J., Cuthbertson, J., Ashcroft, F.M., Ezaki, T., Doyle, D.A.
Deposit date:2003-05-01
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Crystal structure of the potassium channel KirBac1.1 in the closed state.
Science, 300, 2003
1Q4K
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THE POLO-BOX DOMAIN OF PLK1 IN COMPLEX WITH A PHOSPHO-PEPTIDE
Descriptor:Serine/threonine-protein kinase PLK, Phospho-peptide sequence Met.Gln.Ser.pThr.Pro.Leu
Authors:Cheng, K., Lowe, E.D., Sinclair, J., Nigg, E.A., Johnson, L.N.
Deposit date:2003-08-04
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
Embo J., 22, 2003
1Q4O
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THE STRUCTURE OF THE POLO BOX DOMAIN OF HUMAN PLK1
Descriptor:Serine/threonine-protein kinase PLK
Authors:Cheng, K.Y., Lowe, E.D., Sinclair, J., Nigg, E.A., Johnson, L.N.
Deposit date:2003-08-04
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
Embo J., 22, 2003
1UA2
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CRYSTAL STRUCTURE OF HUMAN CDK7
Descriptor:Cell division protein kinase 7, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lolli, G., Lowe, E.D., Brown, N.R., Johnson, L.N.
Deposit date:2004-08-11
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:The Crystal Structure of Human CDK7 and Its Protein Recognition Properties
Structure, 12, 2004
1Z96
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CRYSTAL STRUCTURE OF THE MUD1 UBA DOMAIN
Descriptor:UBA-domain protein mud1
Authors:Trempe, J.-F., Brown, N.R., Lowe, E.D., Noble, M.E.M., Gordon, C., Campbell, I.D., Johnson, L.N., Endicott, J.A.
Deposit date:2005-03-31
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain
Embo J., 24, 2005
2CCH
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THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
2CCI
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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6
Descriptor:Cyclin-dependent kinase 2, Cyclin-A2, Cell division control protein 6 homolog, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2JGZ
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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B
Descriptor:CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1
Authors:Brown, N.R., Petri, E., Lowe, E.D., Skamnaki, V., Johnson, L.N.
Deposit date:2007-02-17
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cyclin B and Cyclin a Confer Different Substrate Recognition Properties on Cdk2.
Cell Cycle, 6, 2007
2JK1
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CRYSTAL STRUCTURE OF THE WILD-TYPE HUPR RECEIVER DOMAIN
Descriptor:HYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN HUPR1, MAGNESIUM ION
Authors:Davies, K.M., Lowe, E.D., Venien-Bryan, C., Johnson, L.N.
Deposit date:2008-05-26
Release date:2008-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Hupr Receiver Domain Crystal Structure in its Nonphospho and Inhibitory Phospho States.
J.Mol.Biol., 385, 2009
2V76
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CRYSTAL STRUCTURE OF THE HUMAN DOK1 PTB DOMAIN
Descriptor:DOCKING PROTEIN 1, TRIETHYLENE GLYCOL, SULFATE ION, ...
Authors:Oxley, C.L., Anthis, N.J., Lowe, E.D., Campbell, I.D., Wegener, K.L.
Deposit date:2007-07-26
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Integrin Phosphorylation Switch: The Effect of {Beta}3 Integrin Tail Phosphorylation on Dok1 and Talin Binding.
J.Biol.Chem., 283, 2008
2V9C
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X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PSEUDOMONAS AERUGINOSA AZOREDUCTASE IN COMPLEX WITH METHYL RED.
Descriptor:FMN-DEPENDENT NADH-AZOREDUCTASE 1, FLAVIN MONONUCLEOTIDE, 2-(4-DIMETHYLAMINOPHENYL)DIAZENYLBENZOIC ACID, ...
Authors:Wang, C.-J., Hagemeier, C., Rahman, N., Lowe, E.D., Noble, M.E.M., Coughtrie, M., Sim, E., Westwood, I.M.
Deposit date:2007-08-23
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Molecular Cloning, Characterisation and Ligand- Bound Structure of an Azoreductase from Pseudomonas Aeruginosa
J.Mol.Biol., 373, 2007
2VF2
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X-RAY CRYSTAL STRUCTURE OF HSAD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD, GLYCEROL, SULFATE ION
Authors:Lack, N., Lowe, E.D., Liu, J., Eltis, L.D., Noble, M.E.M., Sim, E., Westwood, I.M.
Deposit date:2007-10-29
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of Hsad, a Steroid-Degrading Hydrolase, from Mycobacterium Tuberculosis.
Acta Crystallogr.,Sect.F, 64, 2008