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2VLE
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BU of 2vle by Molmil
The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase
Descriptor: ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL, DAIDZIN
Authors:Lowe, E.D, Gao, G.Y, Johnson, L.N, Keung, W.M.
Deposit date:2008-01-13
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase.
J.Med.Chem., 51, 2008
2BWF
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BU of 2bwf by Molmil
Crystal structure of the UBL domain of Dsk2 from S. cerevisiae
Descriptor: FORMIC ACID, UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWB
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BU of 2bwb by Molmil
Crystal structure of the UBA domain of Dsk2 from S. cerevisiae
Descriptor: UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWE
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BU of 2bwe by Molmil
The crystal structure of the complex between the UBA and UBL domains of Dsk2
Descriptor: DSK2
Authors:Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2PHK
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BU of 2phk by Molmil
THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ...
Authors:Lowe, E.D, Noble, M.E.M, Skamnaki, V.T, Oikonomakos, N.G, Owen, D.J, Johnson, L.N.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
EMBO J., 16, 1997
7NNA
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BU of 7nna by Molmil
Toxin Import Through the Antibiotic Efflux Channel TolC
Descriptor: Klebicin C activity
Authors:Lowe, E.D, Kleanthous, C, Housden, N.G.
Deposit date:2021-02-24
Release date:2021-07-07
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Toxin import through the antibiotic efflux channel TolC.
Nat Commun, 12, 2021
7QI3
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BU of 7qi3 by Molmil
Structure of Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase
Descriptor: 1,2-ETHANEDIOL, Arylamine N-acetyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Lowe, E.D, Kotomina, E, Karagianni, E, Boukouvala, S.
Deposit date:2021-12-14
Release date:2022-11-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues.
Febs J., 290, 2023
1W98
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BU of 1w98 by Molmil
The structural basis of CDK2 activation by cyclin E
Descriptor: CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1
Authors:Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N.
Deposit date:2004-10-07
Release date:2005-02-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles
Embo J., 24, 2005
1H26
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BU of 1h26 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
Descriptor: CELL DIVISION PROTEIN KINASE 2, CELLULAR TUMOR ANTIGEN P53, CYCLIN A2
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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BU of 1h25 by Molmil
CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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BU of 1h27 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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BU of 1h28 by Molmil
CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H24
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BU of 1h24 by Molmil
CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
4V3E
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BU of 4v3e by Molmil
The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ...
Authors:Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
4X0J
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BU of 4x0j by Molmil
Trypanosoma brucei haptoglobin-haemoglobin receptor
Descriptor: Haptoglobin-hemoglobin receptor
Authors:Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K.
Deposit date:2014-11-21
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
4V3D
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BU of 4v3d by Molmil
The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ...
Authors:Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K.
Deposit date:2014-10-17
Release date:2014-12-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
7VCE
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BU of 7vce by Molmil
Structural studies of human inositol monophosphatase-1 inhibition by ebselen
Descriptor: Inositol monophosphatase 1
Authors:Abuhammad, A, Laurieri, N, Rice, A, Lowe, E.D, McDonough, M.A, Singh, N, Churchill, G.C.
Deposit date:2021-09-02
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and biochemical analysis of human inositol monophosphatase-1 inhibition by ebselen.
J.Biomol.Struct.Dyn., 2023
6THK
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BU of 6thk by Molmil
Structural mechanism of pyocin S5 import into Pseudomonas aeruginosa
Descriptor: GLYCEROL, Pyocin S5, ZINC ION
Authors:Behrens, H.M, Kleanthous, C, Lowe, E.D.
Deposit date:2019-11-20
Release date:2020-03-04
Last modified:2020-03-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pyocin S5 Import into Pseudomonas aeruginosa Reveals a Generic Mode of Bacteriocin Transport.
Mbio, 11, 2020
6XZ1
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BU of 6xz1 by Molmil
Conjugate of the HECT domain of HUWE1 with ubiquitin
Descriptor: HECT, UBA and WWE domain containing 1, isoform CRA_a, ...
Authors:Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S.
Deposit date:2020-01-31
Release date:2021-08-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
4X0L
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BU of 4x0l by Molmil
Human haptoglobin-haemoglobin complex
Descriptor: CACODYLATE ION, GLYCEROL, Haptoglobin, ...
Authors:Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K.
Deposit date:2014-11-21
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
3G9W
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BU of 3g9w by Molmil
Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ...
Authors:Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
5JZS
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BU of 5jzs by Molmil
HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid
Descriptor: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD, 3,5-dichloro-4-hydroxybenzoic acid
Authors:Ryan, A, Polycarpou, E, Lack, N, Evangelopoulos, D, Sieg, C, Halman, A, Bhakta, S, Sinclair, A, Eleftheriadou, O, McHugh, T.D, Keany, S, Lowe, E.D, Ballet, R, Abuhammad, A, Ciulli, A, Sim, E.
Deposit date:2016-05-17
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Br. J. Pharmacol., 174, 2017
6FB3
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BU of 6fb3 by Molmil
Teneurin 2 Partial Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Teneurin-2, ...
Authors:Jackson, V.A, Carrasquero, M, Lowe, E.D, Seiradake, E.
Deposit date:2017-12-18
Release date:2018-03-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Nat Commun, 9, 2018
1GY3
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BU of 1gy3 by Molmil
pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ...
Authors:Cook, A, Lowe, E.D, Chrysina, E.D, Skamnaki, V.T, Oikonomakos, N.G, Johnson, L.N.
Deposit date:2002-04-19
Release date:2002-04-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism
Biochemistry, 41, 2002
1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999

217705

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