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1XR5
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CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE 3D FROM HUMAN RHINOVIRUS SEROTYPE 14
分子名称:Genome polyprotein, SAMARIUM (III) ION
著者Love, R.A., Maegley, K.A., Yu, X., Ferre, R.A., Lingardo, L.K., Diehl, W., Parge, H.E., Dragovich, P.S., Fuhrman, S.A.
登録日2004-10-13
公開日2004-10-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy
Structure, 12, 2004
1XR6
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CRYSTAL STRUCTURE OF RNA-DEPENDENT RNA POLYMERASE 3D FROM HUMAN RHINOVIRUS SEROTYPE 1B
分子名称:Genome polyprotein, POTASSIUM ION
著者Love, R.A., Maegley, K.A., Yu, X., Ferre, R.A., Lingardo, L.K., Diehl, W., Parge, H.E., Dragovich, P.S., Fuhrman, S.A.
登録日2004-10-13
公開日2004-10-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy
Structure, 12, 2004
1XR7
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CRYSTAL STRUCTURE OF RNA-DEPENDENT RNA POLYMERASE 3D FROM HUMAN RHINOVIRUS SEROTYPE 16
分子名称:Genome polyprotein
著者Love, R.A., Maegley, K.A., Yu, X., Ferre, R.A., Lingardo, L.K., Diehl, W., Parge, H.E., Dragovich, P.S., Fuhrman, S.A.
登録日2004-10-13
公開日2004-10-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy
Structure, 12, 2004
1OS5
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CRYSTAL STRUCTURE OF HCV NS5B RNA POLYMERASE COMPLEXED WITH A NOVEL NON-COMPETITIVE INHIBITOR.
分子名称:Hepatitis C virus NS5B RNA polymerase, 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE
著者Love, R.A., Parge, H.E., Yu, X., Hickey, M.J., Diehl, W., Gao, J., Wriggers, H., Ekker, A., Wang, L., Thomson, J.A., Dragovich, P.S., Fuhrman, S.A.
登録日2003-03-18
公開日2004-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.
J.Virol., 77, 2003
1IND
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HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE
分子名称:IGG1-LAMBDA CHA255 FAB (LIGHT CHAIN), IGG1-LAMBDA CHA255 FAB (HEAVY CHAIN), INDIUM (III) ION, ...
著者Love, R.A., Butler, W.F.
登録日1993-06-14
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate.
Biochemistry, 32, 1993
1INE
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HOW THE ANTI-(METAL CHELATE) ANTIBODY CHA255 IS SPECIFIC FOR THE METAL ION OF ITS ANTIGEN: X-RAY STRUCTURES FOR TWO FAB'(SLASH)HAPTEN COMPLEXES WITH DIFFERENT METALS IN THE CHELATE
分子名称:IGG1-LAMBDA CHA255 FAB (LIGHT CHAIN), IGG1-LAMBDA CHA255 FAB (HEAVY CHAIN), FE (III) ION, ...
著者Love, R.A., Butler, W.F.
登録日1993-06-14
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate.
Biochemistry, 32, 1993
1A1Q
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HEPATITIS C VIRUS NS3 PROTEINASE
分子名称:NS3 PROTEINASE, ZINC ION
著者Love, R.A., Parge, H.E., Wickersham, J.A., Hostomsky, Z., Habuka, N., Moomaw, E.W., Adachi, T., Hostomska, Z.
登録日1997-12-12
公開日1998-03-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
Cell(Cambridge,Mass.), 87, 1996
3FQM
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CRYSTAL STRUCTURE OF A NOVEL DIMERIC FORM OF HCV NS5A DOMAIN I PROTEIN
分子名称:Non-structural protein 5A, ZINC ION, GLYCEROL
著者Love, R.A.
登録日2009-01-07
公開日2009-03-10
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
J.Virol., 83, 2009
3FQQ
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CRYSTAL STRUCTURE OF A NOVEL DIMERIC FORM OF HCV NS5A DOMAIN I PROTEIN
分子名称:Non-structural protein 5A, ZINC ION, GLYCEROL, ...
著者Love, R.A.
登録日2009-01-07
公開日2009-03-24
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
J.Virol., 83, 2009
2ABX
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THE CRYSTAL STRUCTURE OF ALPHA-BUNGAROTOXIN AT 2.5 ANGSTROMS RESOLUTION. RELATION TO SOLUTION STRUCTURE AND BINDING TO ACETYLCHOLINE RECEPTOR
分子名称:ALPHA-BUNGAROTOXIN
著者Love, R., Stroud, R.
登録日1986-02-19
公開日1986-05-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor.
Protein Eng., 1, 1986
1CQQ
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TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR
分子名称:TYPE 2 RHINOVIRUS 3C PROTEASE, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
著者Matthews, D., Ferre, R.A.
登録日1999-08-10
公開日1999-09-20
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proc.Natl.Acad.Sci.USA, 96, 1999
4H6J
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IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION.
分子名称:HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
著者Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A.
登録日2012-09-19
公開日2012-12-05
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
3IG1
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HIV-1 REVERSE TRANSCRIPTASE WITH THE INHIBITOR BETA-THUJAPLICINOL BOUND AT THE RNASE H ACTIVE SITE
分子名称:HIV-1 Reverse Transcriptase p66 subunit, HIV-1 Reverse Transcriptase p51 subunit, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, ...
著者Himmel, D.M., Maegley, K.A., Pauly, T.A., Arnold, E.
登録日2009-07-27
公開日2010-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure, 17, 2009
3K2P
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HIV-1 REVERSE TRANSCRIPTASE ISOLATED RNASEH DOMAIN WITH THE INHIBITOR BETA-THUJAPLICINOL BOUND AT THE ACTIVE SITE
分子名称:Reverse Transcriptase, MANGANESE (II) ION, 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
著者Pauly, T.A., Himmel, D.M., Maegley, K., Arnold, E.
登録日2009-09-30
公開日2010-02-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure, 17, 2009
1ABT
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NMR SOLUTION STRUCTURE OF AN ALPHA-BUNGAROTOXIN(SLASH)NICOTINIC RECEPTOR PEPTIDE COMPLEX
分子名称:ALPHA-BUNGAROTOXIN, NICOTINIC RECEPTOR PEPTIDE
著者Basus, V.J., Song, G., Hawrot, E.
登録日1993-11-17
公開日1994-01-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex.
Biochemistry, 32, 1993
1BT7
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THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES
分子名称:NS3 SERINE PROTEASE, ZINC ION
著者Barbato, G., Cicero, D.O., Nardi, M.C., Steinkuhler, C., Cortese, R., De Francesco, R., Bazzo, R.
登録日1998-09-01
公開日1999-06-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
J.Mol.Biol., 289, 1999
1KC4
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NMR STRUCTURAL ANALYSIS OF THE COMPLEX FORMED BETWEEN ALPHA-BUNGAROTOXIN AND THE PRINCIPAL ALPHA-NEUROTOXIN BINDING SEQUENCE ON THE ALPHA7 SUBUNIT OF A NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
分子名称:alpha-bungarotoxin, neuronal acetylcholine receptor protein, alpha-7 chain
著者Moise, L., Piserchio, A., Basus, V.J., Hawrot, E.
登録日2001-11-07
公開日2002-03-13
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.
J.Biol.Chem., 277, 2002
1KL8
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NMR STRUCTURAL ANALYSIS OF THE COMPLEX FORMED BETWEEN ALPHA-BUNGAROTOXIN AND THE PRINCIPAL ALPHA-NEUROTOXIN BINDING SEQUENCE ON THE ALPHA7 SUBUNIT OF A NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
分子名称:ALPHA-BUNGAROTOXIN, NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 CHAIN
著者Moise, L., Piserchio, A., Basus, V.J., Hawrot, E.
登録日2001-12-11
公開日2002-03-13
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.
J.Biol.Chem., 277, 2002
2A4G
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HEPATITIS C PROTEASE NS3-4A SERINE PROTEASE WITH KETOAMIDE INHIBITOR SCH225724 BOUND
分子名称:NS3 protease/helicase, NS4a peptide, ZINC ION, ...
著者Arasappan, A., Njoroge, F.G., Chan, T.Y., Bennett, F., Bogen, S.L., Chen, K., Gu, H., Hong, L., Jao, E., Liu, Y.T., Lovey, R.G., Parekh, T., Pike, R.E., Pinto, P., Santhanam, B., Venkatraman, S., Vaccaro, H., Wang, H., Yang, X., Zhu, Z., Mckittrick, B., Saksena, A.K., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Ingram, R., Malcolm, B., Prongay, A.J., Yao, N., Marten, B., Madison, V., Kemp, S., Levy, O., Lim-Wilby, M., Tamura, S., Ganguly, A.K.
登録日2005-06-28
公開日2006-07-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2A4Q
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HCV NS3 PROTEASE WITH NS4A PEPTIDE AND A COVALENTLY BOUND MACROCYCLIC KETOAMIDE COMPOUND.
分子名称:NS3 protease/helicase', NS4a peptide, ZINC ION, ...
著者Chen, K.X., Njoroge, F.G., Prongay, A., Pichardo, J., Madison, V., Girijavallabhan, V.
登録日2005-06-29
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease
Bioorg.Med.Chem.Lett., 15, 2005
2A4R
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HCV NS3 PROTEASE DOMAIN WITH A KETOAMIDE INHIBITOR COVALENTLY BOUND.
分子名称:NS3 protease/helicase, Ns4a peptide, ZINC ION, ...
著者Bogen, S., Saksena, A.K., Arasappan, A., Gu, H., Njoroge, F.G., Girijavallabhan, V., Pichardo, J., Butkiewicz, N., Prongay, A., Madison, V.
登録日2005-06-29
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
3QLH
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH MANICOL AT THE RNASE H ACTIVE SITE AND TMC278 (RILPIVIRINE) AT THE NNRTI BINDING POCKET
分子名称:reverse transcriptase/ribonuclease H, (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Himmel, D.M., Wojtak, K., Bauman, J.D., Arnold, E.
登録日2011-02-02
公開日2011-12-21
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J.Med.Chem., 54, 2011
4QAG
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STRUCTURE OF A DIHYDROXYCOUMARIN ACTIVE-SITE INHIBITOR IN COMPLEX WITH THE RNASE H DOMAIN OF HIV-1 REVERSE TRANSCRIPTASE
分子名称:Reverse transcriptase/ribonuclease H, MANGANESE (II) ION, (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid
著者Himmel, D.M., Ho, W.C., Arnold, E.
登録日2014-05-04
公開日2014-06-04
最終更新日2014-07-09
実験手法X-RAY DIFFRACTION (1.712 Å)
主引用文献Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs.
J.Mol.Biol., 426, 2014