Author results

1A30
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HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
Descriptor:HIV-1 PROTEASE, TRIPEPTIDE GLU-ASP-LEU
Authors:Louis, J.M., Dyda, F., Nashed, N.T., Kimmel, A.R., Davies, D.R.
Deposit date:1998-01-27
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
Biochemistry, 37, 1998
1A94
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STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-16
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1BAI
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CRYSTAL STRUCTURE OF ROUS SARCOMA VIRUS PROTEASE IN COMPLEX WITH INHIBITOR
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-17
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1DAZ
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1DW6
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1EBK
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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Reed, C.C., Adomat, J.M., Krouse, J., Wang, Y.F., Harrison, R.W., Weber, I.T.
Deposit date:2000-01-24
Release date:2000-07-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
3MWS
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CRYSTAL STRUCTURE OF GROUP N HIV-1 PROTEASE
Descriptor:HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Sayer, J.M., Agniswamy, J., Weber, I.T., Louis, J.M.
Deposit date:2010-05-06
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.
Protein Sci., 19, 2010
3UCB
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CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH DARUNAVIR
Descriptor:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Agniswamy, J., Chen-Hsiang, S., Aniana, A., Sayer, J.M., Louis, J.M., Weber, I.T.
Deposit date:2011-10-26
Release date:2012-03-28
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Biochemistry, 51, 2012
3UF3
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CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20
Descriptor:HIV-1 protease, YTTRIUM ION, GLYCEROL
Authors:Agniswamy, J., Chen-Hsiang, S., Aniana, A., Sayer, J.M., Louis, J.M., Weber, I.T.
Deposit date:2011-10-31
Release date:2012-03-28
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Biochemistry, 51, 2012
3UFN
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CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH SAQUINAVIR
Descriptor:HIV-1 protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION
Authors:Agniswamy, J., Chen-Hsiang, S., Aniana, A., Sayer, J.M., Louis, J.M., Weber, I.T.
Deposit date:2011-11-01
Release date:2012-03-28
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Biochemistry, 51, 2012
1A8K
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CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
Descriptor:HIV PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Weber, I.T., Wu, J., Adomat, J., Harrison, R.W., Kimmel, A.R., Wondrak, E.M., Louis, J.M.
Deposit date:1998-03-27
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.
Eur.J.Biochem., 249, 1997
1FEJ
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-21
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FF0
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-24
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFF
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FFI
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG6
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FG8
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-25
Release date:2001-06-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1FGC
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:PROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
Authors:Mahalingam, B., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2000-07-28
Release date:2001-06-01
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1K1T
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COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, SULFATE ION
Authors:Mahalingam, B., Boross, P., Wang, Y.-F., Louis, J.M., Fischer, C., Tozser, J., Harrison, R.W., Weber, I.T.
Deposit date:2001-09-25
Release date:2002-07-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K1U
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COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Boross, P., Wang, Y.-F., Louis, J.M., Fischer, C., Tozser, J., W Harrison, R., Weber, I.T.
Deposit date:2001-09-25
Release date:2002-07-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K2B
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COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Boross, P., Wang, Y.-F., Louis, J.M., Fischer, C., Tozser, J., W Harrison, R., Weber, I.T.
Deposit date:2001-09-26
Release date:2002-07-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K2C
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COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE
Descriptor:PROTEASE RETROPEPSIN, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Mahalingam, B., Boross, P., Wang, Y.-F., Louis, J.M., Fischer, C., Tozser, J., W Harrison, R., Weber, I.T.
Deposit date:2001-09-26
Release date:2002-07-10
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1L2M
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MINIMIZED AVERAGE STRUCTURE OF THE N-TERMINAL, DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN FROM A GEMINIVIRUS (TOMATO YELLOW LEAF CURL VIRUS-SARDINIA)
Descriptor:Rep protein
Authors:Campos-Olivas, R., Louis, J.M., Clerot, D., Gronenborn, B., Gronenborn, A.M.
Deposit date:2002-02-22
Release date:2002-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of a replication initiator unites diverse aspects of nucleic acid metabolism
Proc.Natl.Acad.Sci.USA, 99, 2002
1L5B
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DOMAIN-SWAPPED CYANOVIRIN-N DIMER
Descriptor:cyanovirin-N, SODIUM ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Barrientos, L.G., Louis, J.M., Botos, I., Mori, T., Han, Z., O'Keefe, B.R., Boyd, M.R., Wlodawer, A., Gronenborn, A.M.
Deposit date:2002-03-06
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.
Structure, 10, 2002
1L5E
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THE DOMAIN-SWAPPED DIMER OF CV-N IN SOLUTION
Descriptor:Cyanovirin-N
Authors:Barrientos, L.G., Louis, J.M., Botos, I., Mori, T., Han, Z., O'Keefe, B.R., Boyd, M.R., Wlodawer, A., Gronenborn, A.M.
Deposit date:2002-03-06
Release date:2002-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.
Structure, 10, 2002