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6N10
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE 1 COMPLEXED WITH (R)-MVAPP
Descriptor:Diphosphomevalonate decarboxylase MVD1, peroxisomal, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, ...
Authors:Noel, J.P., Thomas, S.T., Louie, G.V.
Deposit date:2018-11-07
Release date:2019-07-17
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
Acs Chem.Biol., 14, 2019
6N0Z
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CRYSTAL STRUCTURE OF ANAEROLINEA THERMOPHILA MEVALONATE 5-PHOSPHATE DECARBOXYLASE N20K H194M MUTANT COMPLEXED WITH (R)-MVAPP
Descriptor:Diphosphomevalonate decarboxylase, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID
Authors:Noel, J.P., Thomas, S.T., Louie, G.V.
Deposit date:2018-11-07
Release date:2019-07-17
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
Acs Chem.Biol., 14, 2019
6N0Y
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CRYSTAL STRUCTURE OF ANAEROLINEA THERMOPHILA MEVALONATE 5-PHOSPHATE DECARBOXYLASE COMPLEXED WITH (R)-MVAPP
Descriptor:Diphosphomevalonate decarboxylase, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID
Authors:Noel, J.P., Thomas, S.T., Louie, G.V.
Deposit date:2018-11-07
Release date:2019-07-17
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
Acs Chem.Biol., 14, 2019
6N0X
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CRYSTAL STRUCTURE OF ANAEROLINEA THERMOPHILA MEVALONATE 5-PHOSPHATE DECARBOXYLASE COMPLEXED WITH (R)-MVAP
Descriptor:Diphosphomevalonate decarboxylase, (3R)-3-HYDROXY-3-METHYL-5-(PHOSPHONOOXY)PENTANOIC ACID
Authors:Noel, J.P., Thomas, S.T., Louie, G.V.
Deposit date:2018-11-07
Release date:2019-07-17
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
Acs Chem.Biol., 14, 2019
5JO7
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HENBANE PREMNASPIRODIENE SYNTHASE (HPS), ALSO KNOWN AS HENBANE VETISPIRADIENE SYNTHASE (HVS) FROM HYOSCYAMUS MUTICUS
Descriptor:Vetispiradiene synthase 1
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-05-02
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Functional study of terpene synthase from 512 mutant library of henbane premnaspirodiene synthase reveals protein residue interactions
To Be Published
5IM1
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITHOUT BUFFER MOLECULE IN THE ACTIVE SITE
Descriptor:5-epi-aristolochene synthase
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILZ
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS PROPANE (BTP) BUFFER MOLECULE
Descriptor:5-epi-aristolochene synthase, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILY
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS BUFFER MOLECULE AND DIPHOSPHATE (PPI)
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-05
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILK
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH PARTIAL DENSITY FROM MOPSO OR BIS-TRIS BUFFER MOLECULE IN THE ACTIVE SITE
Descriptor:5-epi-aristolochene synthase
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILJ
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH BIS-TRIS BUFFER MOLECULE
Descriptor:5-epi-aristolochene synthase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILI
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH CAPSO BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILH
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH CAPSO BUFFER MOLECULE AND CA2+ IONS
Descriptor:5-epi-aristolochene synthase, CALCIUM ION, (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5ILD
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MES BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5IL8
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MOPSO BUFFER MOLECULE AND CA2+ IONS
Descriptor:5-epi-aristolochene synthase, CALCIUM ION, (2S)-2-hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5IL3
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH MOPSO BUFFER MOLECULE AND MG2+ IONS
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2S)-2-hydroxy-3-(morpholin-4-yl)propane-1-sulfonic acid, ...
Authors:Koo, H.J., Louie, G.V., Xu, Y., Bowman, M., Noel, J.P.
Deposit date:2016-03-04
Release date:2017-03-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Small-molecule buffer components can directly affect terpene-synthase activity by interacting with the substrate-binding site of the enzyme
To Be Published
5IKH
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE M4 MUTANT WITH (-)-PREMNASPIRODIENE
Descriptor:5-epi-aristolochene synthase, (2R,5S,10R)-6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-ene, MAGNESIUM ION
Authors:Koo, H.J., O'Maille, P.E., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IKA
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK9
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TOBACCO 5-EPI-ARISTOLOCHENE WITH FARNESYL MONOPHOSPHATE
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, (2E,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl dihydrogen phosphate
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK6
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH GERMACRENE A AND PPI
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, GERMACRENE A, ...
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5IK0
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TOBACCO 5-EPI-ARISTOLOCHENE SYNTHASE WITH FPP
Descriptor:5-epi-aristolochene synthase, MAGNESIUM ION, FARNESYL DIPHOSPHATE
Authors:Koo, H.J., Xu, Y., Louie, G.V., Bowman, M., Noel, J.P.
Deposit date:2016-03-03
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.
J.Antibiot., 69, 2016
5BVA
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STRUCTURE OF FLAVIN-DEPENDENT BROMINASE BMP2
Descriptor:flavin-dependent halogenase, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL
Authors:Agarwal, V., Louie, G.V., Noel, J.P., Moore, B.S.
Deposit date:2015-06-04
Release date:2016-03-09
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.873 Å)
Cite:Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BUL
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STRUCTURE OF FLAVIN-DEPENDENT BROMINASE BMP2 TRIPLE MUTANT Y302S F306V A345W
Descriptor:flavin-dependent halogenase triple mutant, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Agarwal, V., Louie, G.V., Noel, J.P., Moore, B.S.
Deposit date:2015-06-04
Release date:2016-03-09
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.9784 Å)
Cite:Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BUK
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STRUCTURE OF FLAVIN-DEPENDENT CHLORINASE MPY16
Descriptor:FADH2-dependent halogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Agarwal, V., Louie, G.V., Noel, J.P., Moore, B.S.
Deposit date:2015-06-03
Release date:2016-03-09
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
4R1U
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CRYSTAL STRUCTURE OF MEDICAGO TRUNCATULA CINNAMOYL-COA REDUCTASE
Descriptor:Cinnamoyl CoA reductase, ACETATE ION
Authors:Noel, J.P., Bomati, E.K., Louie, G.V., Bowman, M.E.
Deposit date:2014-08-07
Release date:2014-10-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis.
Plant Cell, 26, 2014
4R1T
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CRYSTAL STRUCTURE OF PETUNIA HYDRIDA CINNAMOYL-COA REDUCTASE
Descriptor:cinnamoyl CoA reductase, molecular iodine
Authors:Noel, J.P., Louie, G.V., Bowman, M.E., Bomati, E.K.
Deposit date:2014-08-07
Release date:2014-10-01
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis.
Plant Cell, 26, 2014