Author results

1CKI
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RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317
分子名称:CASEIN KINASE I DELTA
著者Longenecker, K.L., Roach, P.J., Hurley, T.D.
登録日1995-08-25
公開日1995-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1CKJ
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CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE
分子名称:RECOMBINANT CASEIN KINASE I DELTA, TUNGSTATE(VI)ION
著者Longenecker, K.L., Roach, P.J., Hurley, T.D.
登録日1995-08-25
公開日1995-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1F7C
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CRYSTAL STRUCTURE OF THE BH DOMAIN FROM GRAF, THE GTPASE REGULATOR ASSOCIATED WITH FOCAL ADHESION KINASE
分子名称:RHOGAP PROTEIN
著者Longenecker, K.L., Derewenda, U., Sheffield, P.J., Zheng, Y., Derewenda, Z.S.
登録日2000-06-26
公開日2000-12-20
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the BH domain from graf and its implications for Rho GTPase recognition.
J.Biol.Chem., 275, 2000
1FSO
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CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI QUADRUPLE MUTANT
分子名称:RHO GDP-DISSOCIATION INHIBITOR 1
著者Longenecker, K.L., Garrard, S.M., Sheffield, P.J., Derewenda, Z.S.
登録日2000-09-11
公開日2001-05-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Acta Crystallogr.,Sect.D, 57, 2001
1FST
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CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI TRIPLE MUTANT
分子名称:RHO GDP-DISSOCIATION INHIBITOR 1
著者Longenecker, K.L., Garrard, S.M., Sheffield, P.J., Derewenda, Z.S.
登録日2000-09-11
公開日2001-05-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Acta Crystallogr.,Sect.D, 57, 2001
1FT0
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CRYSTAL STRUCTURE OF TRUNCATED HUMAN RHOGDI K113A MUTANT
分子名称:RHO GDP-DISSOCIATION INHIBITOR 1
著者Longenecker, K.L., Garrard, S.M., Sheffield, P.J., Derewenda, Z.S.
登録日2000-09-11
公開日2001-05-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Acta Crystallogr.,Sect.D, 57, 2001
1FT3
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CRYSTAL STRUCTURE OF TRUNCATED RHOGDI K141A MUTANT
分子名称:RHO GDP-DISSOCIATION INHIBITOR 1
著者Longenecker, K.L., Garrard, S.M., Sheffield, P.J., Derewenda, Z.S.
登録日2000-09-11
公開日2001-05-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Acta Crystallogr.,Sect.D, 57, 2001
1HTJ
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STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF
分子名称:KIAA0380
著者Longenecker, K.L., Lewis, M.E., Chikumi, H., Gutkind, J.S., Derewenda, Z.S.
登録日2000-12-29
公開日2001-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.
Structure, 9, 2001
2AM1
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SP PROTEIN LIGAND 1
分子名称:UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein, 2,4-DICHLORO-N-(3-CYANO-4,5,6,7-TETRAHYDRO-BENZOTHIOPHEN-2YL)-5-(MORPHOLINE-4-SULFONYL)-BENZAMIDE, ...
著者Longenecker, K.L., Stamper, G.F., Hajduk, P.J., Fry, E.H., Jakob, C.G., Harlan, J.E., Edalji, R., Bartley, D.M., Walter, K.A., Solomon, L.R.
登録日2005-08-08
公開日2006-01-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2AM2
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SP PROTEIN LIGAND 2
分子名称:UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein, 2-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDE
著者Longenecker, K.L., Stamper, G.F., Hajduk, P.J., Fry, E.H., Jakob, C.G., Harlan, J.E., Edalji, R., Bartley, D.M., Walter, K.A., Solomon, L.R.
登録日2005-08-08
公開日2006-01-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2GBC
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NATIVE DPP-IV (CD26) FROM RAT
分子名称:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE
著者Longenecker, K.L., Jakob, C.G., Fry, E.H., Wilk, S.
登録日2006-03-10
公開日2006-07-04
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
2GBF
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RAT DPP-IV WITH ALKYNYL CYANOPYRROLIDINE #1
分子名称:Dipeptidyl peptidase 4, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
著者Longenecker, K.L., Jakob, C.G., Fry, E.H., Wilk, S.
登録日2006-03-10
公開日2006-07-04
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
2GBG
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RAT DPP-IV WITH ALKYNYL CYANOPYRROLIDINE #2
分子名称:Dipeptidyl peptidase 4, SULFATE ION, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
著者Longenecker, K.L., Jakob, C.G., Fry, E.H., Wilk, S.
登録日2006-03-10
公開日2006-07-04
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
2GBI
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RAT DPP-IV WITH XANTHINE INHIBITOR 4
分子名称:Dipeptidyl peptidase 4, 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE
著者Longenecker, K.L., Jakob, C.G., Fry, E.H., Wilk, S.
登録日2006-03-10
公開日2006-07-04
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45, 2006
3E8U
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CRYSTAL STRUCTURE AND THERMODYNAMIC ANALYSIS OF DIAGNOSTIC FAB 106.3 COMPLEXED WITH BNP 5-13 (C10A) REVEAL BASIS OF SELECTIVE MOLECULAR RECOGNITION
分子名称:Fab 106.3 heavy chain, Fab 106.3 light chain, BNP peptide epitope
著者Longenecker, K.L., Ruan, Q., Fry, E.H., Saldana, S.S., Brophy, S.E., Richardson, P.L., Tetin, S.Y.
登録日2008-08-20
公開日2009-07-07
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).
Proteins, 76, 2009
2I03
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE 4 (DPP IV) WITH POTENT ALKYNYL CYANOPYRROLIDINE (ABT-279)
分子名称:Dipeptidyl peptidase 4, 2-[4-({2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-2-OXOETHYL}AMINO)-4-METHYLPIPERIDIN-1-YL]ISONICOTINIC ACID
著者Longenecker, K.L., Madar, D.J.
登録日2006-08-09
公開日2006-12-12
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J.Med.Chem., 49, 2006
4OCX
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FAB COMPLEX WITH METHOTREXATE
分子名称:Fab ADD056 Heavy Chain, Fab ADD056 Light Chain, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID
著者Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S.
登録日2014-01-09
公開日2014-07-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Water channel in the binding site of a high affinity anti-methotrexate antibody.
Biochemistry, 53, 2014
4OCY
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FAB FOR METHOTREXATE (UNBOUND APO)
分子名称:Fab ADD058 Heavy Chain, Fab ADD058 Light Chain
著者Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S.
登録日2014-01-09
公開日2014-07-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Water channel in the binding site of a high affinity anti-methotrexate antibody.
Biochemistry, 53, 2014
5DYO
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FAB43.1 COMPLEX WITH FLOURESCEIN
分子名称:Fab 43.1 Heavy Chain, Fab 43.1 Light Chain, 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, ...
著者Longenecker, K.L., Judge, R.A.
登録日2015-09-25
公開日2016-01-27
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Three-dimensional structure, binding, and spectroscopic characteristics of the monoclonal antibody 43.1 directed to the carboxyphenyl moiety of fluorescein.
Biopolymers, 105, 2016
5U2M
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1293201
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, SULFATE ION
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5U2N
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1326133
分子名称:Nicotinamide phosphoribosyltransferase, SULFATE ION, N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5UPE
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 5
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(3-phenylpropyl)carbamoyl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
5UPF
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 53
分子名称:Nicotinamide phosphoribosyltransferase, 5-fluoro-N-{4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
5WI0
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH FRAGMENT 2: 2-[(2-FLUOROPHENYL)AMINO]-6-PROPYLPYRIMIDIN-4(3H)-ONE
分子名称:Nicotinamide phosphoribosyltransferase, 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-07-18
公開日2018-01-10
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Fragment-based discovery of a potent NAMPT inhibitor.
Bioorg. Med. Chem. Lett., 28, 2018
5WI1
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH FRAGMENT 5: (3E)-3-[(PHENYLAMINO)METHYLIDENE]OXAN-2-ONE
分子名称:Nicotinamide phosphoribosyltransferase, (3E)-3-[(phenylamino)methylidene]oxan-2-one, SULFATE ION
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-07-18
公開日2018-01-10
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Fragment-based discovery of a potent NAMPT inhibitor.
Bioorg. Med. Chem. Lett., 28, 2018
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