Author results

3U0Z
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U10
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U11
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TETRAMERIZATION DYNAMICS OF THE C-TERMINUS UNDERLIES ISOFORM-SPECIFIC CAMP-GATING IN HCN CHANNELS
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL
著者Lolicato, M., Nardini, M., Gazzarrini, S., Moller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2013-07-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
4KL1
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HCN4 CNBD IN COMPLEX WITH CGMP
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, CYCLIC GUANOSINE MONOPHOSPHATE, ACETATE ION, ...
著者Lolicato, M., Arrigoni, C., Zucca, S., Nardini, M., Bucchi, A., Schroeder, I., Simmons, K., Bolognesi, M., DiFrancesco, D., Schwede, F., Fishwick, C.W.G., Johnson, A.P.K., Thiel, G., Moroni, A.
登録日2013-05-07
公開日2014-04-30
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat.Chem.Biol., 10, 2014
4RUE
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HUMAN K2P4.1 (TRAAK) POTASSIUM CHANNEL, G124I MUTANT
分子名称:Potassium channel subfamily K member 4, POTASSIUM ION
著者Lolicato, M., Minor, D.L.Jr.
登録日2014-11-19
公開日2014-12-17
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels.
Neuron, 84, 2014
4RUF
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HUMAN K2P4.1 (TRAAAK) POTASSIUM CHANNEL, W262S MUTANT
分子名称:Potassium channel subfamily K member 4, POTASSIUM ION
著者Lolicato, M., Minor, D.L.Jr.
登録日2014-11-19
公開日2014-12-17
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels.
Neuron, 84, 2014
6CQ6
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K2P2.1(TREK-1) APO STRUCTURE
分子名称:Potassium channel subfamily K member 2, CADMIUM ION, POTASSIUM ION, ...
著者Lolicato, M., Minor, D.L.
登録日2018-03-14
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6CQ8
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K2P2.1(TREK-1):ML335 COMPLEX
分子名称:Potassium channel subfamily K member 2, POTASSIUM ION, HEXADECANE, ...
著者Lolicato, M., Minor, D.L.
登録日2018-03-14
公開日2018-03-28
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6CQ9
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K2P2.1(TREK-1):ML402 COMPLEX
分子名称:Potassium channel subfamily K member 2, POTASSIUM ION, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide, ...
著者Lolicato, M., Minor, D.L.
登録日2018-03-14
公開日2018-04-11
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6AOD
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FXIA ANTIBODY COMPLEX
分子名称:FXIa Antibody FAB Light Chain, FXIa Antibody FAB Heavy Chain, Coagulation factor XI, ...
著者Lolicato, M., Minor, D.L.
登録日2017-08-15
公開日2018-03-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
Structure, 26, 2018
6BGI
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN NANODISC
分子名称:Anoctamin-1, CALCIUM ION
著者Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, J., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
登録日2017-10-28
公開日2017-12-27
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6BGJ
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN LMNG
分子名称:Anoctamin-1, CALCIUM ION
著者Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, L., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
登録日2017-10-28
公開日2017-12-27
最終更新日2018-04-11
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6O0D
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SAXIPHILIN APO STRUCTURE
分子名称:Saxiphilin
著者Yen, T.J., Lolicato, M., Minor, D.L.
登録日2019-02-16
公開日2019-07-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
6O0E
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SAXIPHILIN:STX COMPLEX, SOAKING
分子名称:Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
著者Yen, T.J., Lolicato, M., Minor, D.L.
登録日2019-02-16
公開日2019-07-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
6O0F
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SAXIPHILIN:STX COMPLEX, CO-CRYSTAL
分子名称:Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
著者Yen, T.J., Lolicato, M., Minor, D.L.
登録日2019-02-16
公開日2019-07-10
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
4NVP
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STRUCTURE OF THE CYCLIC NUCLEOTIDE-BINDING DOMAIN OF HCN4 CHANNEL COMPLEXED WITH 7-CH-CAMP
分子名称:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
著者Alfieri, A., Moroni, A.
登録日2013-12-05
公開日2014-03-19
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
6C4X
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMMEM
分子名称:cross-alpha amyloid-like membrane peptide alpha-AmMEM, (4S)-2-METHYL-2,4-PENTANEDIOL, ZINC ION
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C4Y
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMG
分子名称:Cross-alpha Amyloid-like Structure alphaAmG
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C4Z
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMG - LOW RESOLUTION
分子名称:Cross-alpha Amyloid-like Structure alphaAmG - low resolution
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C50
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMS
分子名称:Cross-alpha Amyloid-like Structure alphaAmS, FORMIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C51
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAML
分子名称:Cross-alpha Amyloid-like Structure alphaAmL, PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6C52
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHATET
分子名称:Cross-alpha Amyloid-like Structure alphaTet, GLYCEROL
著者Liu, L., Zhang, S.Q.
登録日2018-01-13
公開日2018-08-15
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6D02
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAML, 2ND FORM
分子名称:alpha-Amyloid peptide alphaAmL, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, ...
著者Zhang, S.-Q., Liu, L., Degrado, W.F.
登録日2018-04-10
公開日2019-02-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures.
Nat. Chem. Biol., 14, 2018
6O3N
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CROSS-ALPHA AMYLOID-LIKE STRUCTURE ALPHAAMA
分子名称:Cross-alpha Amyloid-like Structure alphaAmA
著者Zhang, S.-Q., Liu, L., DeGrado, W.F.
登録日2019-02-26
公開日2019-03-13
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Designed peptides that assemble into cross-alpha amyloid-like structures
Nat. Chem. Biol., 14, 2018