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1XLU
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X-RAY STRUCTURE OF DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) INHIBITED BUTYRYLCHOLINESTERASE AFTER AGING
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
1XLV
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ETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH ECHOTHIOPHATE
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.247 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
1XLW
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DIETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (NONAGED) OBTAINED BY REACTION WITH ECHOTHIOPHATE
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
1P0I
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CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0M
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CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE IN COMPLEX WITH A CHOLINE MOLECULE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0P
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CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYL CHOLINESTERASE IN COMPLEX WITH THE SUBSTRATE ANALOG BUTYRYLTHIOCHOLINE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0Q
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CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYL CHOLINESTERASE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
2PM8
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CRYSTAL STRUCTURE OF RECOMBINANT FULL LENGTH HUMAN BUTYRYLCHOLINESTERASE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Ngamelue, M.N., Homma, K., Lockridge, O., Asojo, O.A.
Deposit date:2007-04-20
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase.
Acta Crystallogr.,Sect.F, 63, 2007
2XMB
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH SULFATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, CHLORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMC
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH FLUORIDE ANION
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, FLUORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMD
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH ECHOTHIOPHATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, DIETHYL PHOSPHONATE, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMG
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH VX
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
3DL4
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NON-AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN- UPDATE
Descriptor:Acetylcholinesterase, HEXAETHYLENE GLYCOL
Authors:Carletti, E., Li, H., Li, B., Ekstrom, F., Nicolet, Y., Loiodice, M., Gillon, E., Froment, M.T., Lockridge, O., Schopfer, L.M., Masson, P., Nachon, F.
Deposit date:2008-06-26
Release date:2008-12-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
3DL7
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AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN- UPDATE
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Carletti, E., Li, H., Li, B., Ekstrom, F., Nicolet, Y., Loiodice, M., Gillon, E., Froment, M.T., Lockridge, O., Schopfer, L.M., Masson, P., Nachon, F.
Deposit date:2008-06-26
Release date:2008-12-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
3O9M
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CO-CRYSTALLIZATION STUDIES OF FULL LENGTH RECOMBINANT BCHE WITH COCAINE OFFERS INSIGHTS INTO COCAINE DETOXIFICATION
Descriptor:Cholinesterase, BENZOIC ACID
Authors:Asojo, O.A., Ngamelue, M.N., Homma, K., Lockridge, O.
Deposit date:2010-08-04
Release date:2011-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine.
Acta Crystallogr.,Sect.F, 67, 2011
4AQD
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CRYSTAL STRUCTURE OF FULLY GLYCOSYLATED HUMAN BUTYRYLCHOLINESTERASE
Descriptor:BUTYRYLCHOLINESTERASE, BETA-ALANINE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Brazzolotto, X., Wandhammer, M., Ronco, C., Trovaslet, M., Jean, L., Lockridge, O., Renard, P.Y., Nachon, F.
Deposit date:2012-04-16
Release date:2012-07-04
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.
FEBS J., 279, 2012
4BBZ
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STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (2-MIN SOAK): CRESYL-PHOSPHOSERINE ADDUCT
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
4BC0
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STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY CBDP (12-H SOAK) : CRESYL-PHOSPHOSERINE ADDUCT
Descriptor:ACETYLCHOLINESTERASE, (2-methylphenyl) dihydrogen phosphate, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
4BC1
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STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY CBDP (30-MIN SOAK): CRESYL-SALIGENIN-PHOSPHOSERINE ADDUCT
Descriptor:ACETYLCHOLINESTERASE, O-CRESYL-SALIGENIN PHOSPHATE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
6I2T
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CRYOEM RECONSTRUCTION OF FULL-LENGTH, FULLY-GLYCOSYLATED HUMAN BUTYRYLCHOLINESTERASE TETRAMER
Descriptor:Cholinesterase, lamellipodin-derived polyproline peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Leung, M.R., van Bezouwen, L.S., Schopfer, L.M., Sussman, J.L., Silman, I., Lockridge, O., Zeev-Ben-Mordehai, T.
Deposit date:2018-11-01
Release date:2018-12-19
Last modified:2019-01-09
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2Y1K
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STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (12H SOAK): PHOSPHOSERINE ADDUCT
Descriptor:CHOLINESTERASE, SULFATE ION, SODIUM ION, ...
Authors:Carletti, E., Colletier, J.P., Nachon, F., Weik, M.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-Ray Structure Analysis.
Chem.Res.Toxicol., 24, 2011
3DJY
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Carletti, E., Nachon, F.
Deposit date:2008-06-24
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
3DKK
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AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Carletti, E.
Deposit date:2008-06-25
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008