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5MEN
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HUMAN LEUKOCYTE ANTIGEN A02 PRESENTING ILAKFLHWL, IN COMPLEX WITH COGNATE T-CELL RECEPTOR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Lloyd, A., Crowther, M., Cole, D.K., Sewell, A.K.
Deposit date:2016-11-16
Release date:2016-12-07
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
5MEO
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HUMAN LEUKOCYTE ANTIGEN PRESENTING ILGKFLHRL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Lloyd, A., Crowther, M., Cole, D.K., Sewell, A.K.
Deposit date:2016-11-16
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
5MEP
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HUMAN LEUKOCYTE ANTIGEN A02 PRESENTING ILGKFLHWL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Lloyd, A., Crowther, M., Sewell, A.K.
Deposit date:2016-11-16
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
5MEQ
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HUMAN LEUKOCYTE ANTIGEN A02 PRESENTING ILAKFLHTL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Lloyd, A., Crowther, M., Sewell, A.K.
Deposit date:2016-11-16
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
5MER
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HUMAN LEUKOCYTE ANTIGEN A02 PRESENTING ILAKFLHEL
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Lloyd, A., Crowther, M., Cole, D.K., Sewell, A.K.
Deposit date:2016-11-16
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
J. Biol. Chem., 292, 2017
2EX2
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI
Descriptor:Penicillin-binding protein 4, GLYCEROL
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-07
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
2EX6
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI, COMPLEXED WITH AMPICILLIN
Descriptor:Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-08
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
2EX8
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI, COMPLEXED WITH PENICILLIN-G
Descriptor:Penicillin-binding protein 4, OPEN FORM - PENICILLIN G
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-08
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
2EX9
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI, COMPLEXED WITH PENICILLIN-V
Descriptor:Penicillin-binding protein 4, (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, GLYCEROL
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-08
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
2EXA
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI, COMPLEXED WITH FAROM
Descriptor:Penicillin-binding protein 4, (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, GLYCEROL
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-08
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
2EXB
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 4 (DACB) FROM ESCHERICHIA COLI, COMPLEXED WITH FLOMOX
Descriptor:Penicillin-binding protein 4, 2,2-dimethylpropanoyloxymethyl (2R)-5-(aminocarbonyloxymethyl)-2-[(1R)-1-[[(Z)-2-(2-azanyl-1,3-thiazol-4-yl)pent-2-enoyl]amino]-2-oxidanylidene-ethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate, GLYCEROL
Authors:Kishida, H., Unzai, S., Roper, D.I., Lloyd, A., Park, S.-Y., Tame, J.R.H.
Deposit date:2005-11-08
Release date:2006-06-13
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
Biochemistry, 45, 2006
3K6M
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DYNAMIC DOMAINS OF SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE FROM PIG HEART.
Descriptor:Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial, CHLORIDE ION, ...
Authors:Coker, S., Lloyd, A., Mitchell, E., Lewis, G.R., Shoolingin-Jordan, P., Coker, A.R.
Deposit date:2009-10-09
Release date:2010-07-07
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase.
Acta Crystallogr.,Sect.D, 66, 2010
5EU3
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HLA CLASS I ANTIGEN
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Bianchi, V., Cole, D.K., Sewell, A.K.
Deposit date:2015-11-18
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
5EU4
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HLA CLASS I ANTIGEN
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Bianchi, V., Cole, D.K., Sewell, A.K.
Deposit date:2015-11-18
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
5EU5
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HLA CLASS I ANTIGEN
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Bianchi, V., Cole, D.K., Sewell, A.K.
Deposit date:2015-11-18
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
5EU6
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HLA CLASS I ANTIGEN
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Bianchi, V., Cole, D.K., Sewell, A.K.
Deposit date:2015-11-18
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.
J.Biol.Chem., 291, 2016
6G3J
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MHC A02 ALLELE PRESENTING MTSAIGILVP
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Sewell, A.K.
Deposit date:2018-03-26
Release date:2019-02-20
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Peptide Super-Agonist Enhances T-Cell Responses to Melanoma.
Front Immunol, 10, 2019
4HFR
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HUMAN 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 IN COMPLEX WITH AN ORALLY BIOAVAILABLE ACIDIC INHIBITOR AZD4017.
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid
Authors:Ogg, D.J., Gerhardt, S., Hargreaves, D.
Deposit date:2012-10-05
Release date:2012-10-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
J.Med.Chem., 55, 2012