Author results

6RZ5
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XFEL CRYSTAL STRUCTURE OF THE HUMAN CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH ZAFIRLUKAST
分子名称:Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, zafirlukast, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Luginina, A., Gusach, A., Marin, E., Mishin, A., Brouillette, R., Popov, P., Shiryaeva, A., Besserer-Offroy, E., Longpre, J.M., Lyapina, E., Ishchenko, A., Patel, N., Polovinkin, V., Safronova, N., Bogorodskiy, A., Edelweiss, E., Liu, W., Batyuk, A., Gordeliy, V., Han, G.W., Sarret, P., Katritch, V., Borshchevskiy, V., Cherezov, V.
登録日2019-06-12
公開日2019-10-30
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
6RZ4
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CRYSTAL STRUCTURE OF CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH PRANLUKAST
分子名称:Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, pranlukast, SODIUM ION, ...
著者Luginina, A., Gusach, A., Marin, E., Mishin, A., Brouillette, R., Popov, P., Shiryaeva, A., Besserer-Offroy, E., Longpre, J.M., Lyapina, E., Ishchenko, A., Patel, N., Polovinkin, V., Safronova, N., Bogorodskiy, A., Edelweiss, E., Liu, W., Batyuk, A., Gordeliy, V., Han, G.W., Sarret, P., Katritch, V., Borshchevskiy, V., Cherezov, V.
登録日2019-06-12
公開日2019-10-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
6OIT
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CRYOEM STRUCTURE OF ARABIDOPSIS DDR' COMPLEX (DRD1 PEPTIDE-DMS3-RDM1)
分子名称:Protein RDM1, Protein DEFECTIVE IN MERISTEM SILENCING 3, Protein CHROMATIN REMODELING 35
著者Wongpalee, S.P., Liu, S., Zhou, Z.H., Jacobsen, S.E.
登録日2019-04-09
公開日2019-07-24
最終更新日2019-09-25
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.
Nat Commun, 10, 2019
6OIS
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CRYOEM STRUCTURE OF ARABIDOPSIS DR COMPLEX (DMS3-RDM1)
分子名称:Protein RDM1, Protein DEFECTIVE IN MERISTEM SILENCING 3
著者Wongpalee, S.P., Liu, S., Zhou, Z.H., Jacobsen, S.E.
登録日2019-04-09
公開日2019-07-24
最終更新日2019-09-25
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.
Nat Commun, 10, 2019
6O2L
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NMR STRUCTURE OF THE 2:1 COMPLEX OF A CARBAZOLE DERIVATIVE BMVC BOUND TO C-MYC G-QUADRUPLEX
分子名称:DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), 3,6-bis[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-9H-carbazole
著者Lin, C., Liu, W., Yang, D.
登録日2019-02-24
公開日2019-10-23
実験手法SOLUTION NMR
主引用文献Solution structures of the c-MYC Promoter G-quadruplex bound to a carbazole derivative: Insights into small molecule conformational switch for optimal G4-binding
To Be Published
6NQ9
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CRYSTAL STRUCTURE OF YETJ MUTANT FROM BACILLUS SUBTILIS - D195E
分子名称:Uncharacterized protein YetJ
著者Guo, G., Chang, Y., Liu, Q.
登録日2019-01-19
公開日2019-04-17
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Ion and pH Sensitivity of a TMBIM Ca2+Channel.
Structure, 27, 2019
6NQ8
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CRYSTAL STRUCTURE OF YETJ MUTANT FROM BACILLUS SUBTILIS - D171E
分子名称:Uncharacterized protein YetJ
著者Guo, G., Chang, Y., Liu, Q.
登録日2019-01-19
公開日2019-04-17
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Ion and pH Sensitivity of a TMBIM Ca2+Channel.
Structure, 27, 2019
6NQ7
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS CRYSTALLIZED IN LIPIDIC CUBIC PHASE
分子名称:Uncharacterized protein YetJ, GADOLINIUM ATOM
著者Guo, G., Chang, Y., Liu, Q.
登録日2019-01-19
公開日2019-04-17
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Ion and pH Sensitivity of a TMBIM Ca2+Channel.
Structure, 27, 2019
6NHY
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE DEATH RECEPTOR 5 MUTANT (G217Y) - TRIMER ONLY
分子名称:Tumor necrosis factor receptor superfamily member 10B
著者Chou, J.J., Pan, L., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H., Liu, Z.
登録日2018-12-24
公開日2019-02-27
最終更新日2019-03-20
実験手法SOLUTION NMR
主引用文献Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
6NHW
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE DEATH RECEPTOR 5 - DIMER OF TRIMER
分子名称:Tumor necrosis factor receptor superfamily member 10B
著者Chou, J.J., Pan, L., Fu, Q., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H.
登録日2018-12-24
公開日2019-02-27
最終更新日2019-03-20
実験手法SOLUTION NMR
主引用文献Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
6NHJ
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ATOMIC STRUCTURES AND DELETION MUTANT REVEAL DIFFERENT CAPSID-BINDING PATTERNS AND FUNCTIONAL SIGNIFICANCE OF TEGUMENT PROTEIN PP150 IN MURINE AND HUMAN CYTOMEGALOVIRUSES WITH IMPLICATIONS FOR THERAPEUTIC DEVELOPMENT
分子名称:Major capsid protein, Tegument protein, Small capsomere-interacting protein, ...
著者Liu, W., Dai, X.H., Jih, J., Chan, K., Trang, P., Yu, X.K., Balogun, R., Mei, Y., Liu, F.Y., Zhou, Z.H.
登録日2018-12-22
公開日2019-03-06
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development.
PLoS Pathog., 15, 2019
6NGG
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CRYSTAL STRUCTURE OF HUMAN CD160 V58M MUTANT
分子名称:CD160 antigen
著者Liu, W., Bonanno, J., Almo, S.C.
登録日2018-12-21
公開日2019-07-03
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis of CD160:HVEM Recognition.
Structure, 27, 2019
6NG9
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CRYSTAL STRUCTURE OF HUMAN CD160
分子名称:CD160 antigen
著者Liu, W., Bonanno, J., Almo, S.C.
登録日2018-12-21
公開日2019-07-03
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (1.954 Å)
主引用文献Structural Basis of CD160:HVEM Recognition.
Structure, 27, 2019
6NG3
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CRYSTAL STRUCTURE OF HUMAN CD160 AND HVEM COMPLEX
分子名称:CD160 antigen,Tumor necrosis factor receptor superfamily member 14, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Liu, W., Bonanno, J., Almo, S.C.
登録日2018-12-21
公開日2019-07-03
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural Basis of CD160:HVEM Recognition.
Structure, 27, 2019
6MH8
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HIGH-VISCOSITY INJECTOR-BASED PINK BEAM SERIAL CRYSTALLOGRAPHY OF MICRO-CRYSTALS AT A SYNCHROTRON RADIATION SOURCE
分子名称:Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
著者Martin-Garcia, J.M., Zhu, L., Mendez, D., Lee, M., Chun, E., Li, C., Hu, H., Subramanian, G., Kissick, D., Ogata, C., Henning, R., Ishchenko, A., Dobson, Z., Zhan, S., Weierstall, U., Spence, J.C.H., Fromme, P., Zatsepin, N.A., Fischetti, R.F., Cherezov, V., Liu, W.
登録日2018-09-17
公開日2019-04-24
最終更新日2019-11-06
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Iucrj, 6, 2019
6MH6
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HIGH-VISCOSITY INJECTOR-BASED PINK BEAM SERIAL CRYSTALLOGRAPHY OF MICRO-CRYSTALS AT A SYNCHROTRON RADIATION SOURCE.
分子名称:Proteinase K, CALCIUM ION, NITRATE ION
著者Martin-Garcia, J.M., Zhu, L., Mendez, D., Lee, M., Chun, E., Li, C., Hu, H., Subramanian, G., Kissick, D., Ogata, C., Henning, R., Ishchenko, A., Dobson, Z., Zhan, S., Weierstall, U., Spence, J.C.H., Fromme, P., Zatsepin, N.A., Fischetti, R.F., Cherezov, V., Liu, W.
登録日2018-09-17
公開日2019-04-24
最終更新日2019-11-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Iucrj, 6, 2019
6ME9
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT2 IN COMPLEX WITH RAMELTEON
分子名称:Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, ZINC ION
著者Johansson, L.C., Stauch, B., McCorvy, J., Han, G.W., Patel, N., Batyuk, A., Gati, C., Li, C., Grandner, J., Hao, S., Olsen, R.H.J., Tribo, A.R., Zaare, S., Zhu, L., Zatsepin, N.A., Weierstall, U., Liu, W., Roth, B.L., Katritch, V., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Nature, 569, 2019
6ME8
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT2 (N86D) IN COMPLEX WITH 2-PHENYLMELATONIN
分子名称:Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION
著者Johansson, L.C., Stauch, B., McCorvy, J., Han, G.W., Patel, N., Batyuk, A., Gati, C., Li, C., Grandner, J., Hao, S., Olsen, R.H.J., Tribo, A.R., Zaare, S., Zhu, L., Zatsepin, N.A., Weierstall, U., Liu, W., Roth, B.L., Katritch, V., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Nature, 569, 2019
6ME7
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT2 (H208A) IN COMPLEX WITH 2-PHENYLMELATONIN
分子名称:Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION, ...
著者Johansson, L.C., Stauch, B., McCorvy, J., Han, G.W., Patel, N., Batyuk, A., Gati, C., Li, C., Grandner, J., Hao, S., Olsen, R.H.J., Tribo, A.R., Zaare, S., Zhu, L., Zatsepin, N.A., Weierstall, U., Liu, W., Roth, B.L., Katritch, V., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Nature, 569, 2019
6ME6
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT2 IN COMPLEX WITH 2-PHENYLMELATONIN
分子名称:Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION, ...
著者Johansson, L.C., Stauch, B., McCorvy, J., Han, G.W., Patel, N., Batyuk, A., Gati, C., Li, C., Grandner, J., Hao, S., Olsen, R.H.J., Tribo, A.R., Zaare, S., Zhu, L., Zatsepin, N.A., Weierstall, U., Liu, W., Roth, B.L., Katritch, V., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Nature, 569, 2019
6ME5
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH AGOMELATINE
分子名称:chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, ~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide, OLEIC ACID
著者Stauch, B., Johansson, L.C., McCorvy, J.D., Patel, N., Han, G.W., Gati, C., Batyuk, A., Ishchenko, A., Brehm, W., White, T.A., Michaelian, N., Madsen, C., Zhu, L., Grant, T.D., Grandner, J.M., Olsen, R.H.J., Tribo, A.R., Weierstall, U., Roth, B.L., Katritch, V., Liu, W., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569, 2019
6ME4
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH 2-IODOMELATONIN
分子名称:chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, ...
著者Stauch, B., Johansson, L.C., McCorvy, J.D., Patel, N., Han, G.W., Gati, C., Batyuk, A., Ishchenko, A., Brehm, W., White, T.A., Michaelian, N., Madsen, C., Zhu, L., Grant, T.D., Grandner, J.M., Olsen, R.H.J., Tribo, A.R., Weierstall, U., Roth, B.L., Katritch, V., Liu, W., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569, 2019
6ME3
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH 2-PHENYLMELATONIN
分子名称:chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, OLEIC ACID, ...
著者Stauch, B., Johansson, L.C., McCorvy, J.D., Patel, N., Han, G.W., Gati, C., Batyuk, A., Ishchenko, A., Brehm, W., White, T.A., Michaelian, N., Madsen, C., Zhu, L., Grant, T.D., Grandner, J.M., Olsen, R.H.J., Tribo, A.R., Weierstall, U., Roth, B.L., Katritch, V., Liu, W., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569, 2019
6ME2
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XFEL CRYSTAL STRUCTURE OF HUMAN MELATONIN RECEPTOR MT1 IN COMPLEX WITH RAMELTEON
分子名称:chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ...
著者Stauch, B., Johansson, L.C., McCorvy, J.D., Patel, N., Han, G.W., Gati, C., Batyuk, A., Ishchenko, A., Brehm, W., White, T.A., Michaelian, N., Madsen, C., Zhu, L., Grant, T.D., Grandner, J.M., Olsen, R.H.J., Tribo, A.R., Weierstall, U., Roth, B.L., Katritch, V., Liu, W., Cherezov, V.
登録日2018-09-05
公開日2019-04-24
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569, 2019
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
分子名称:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
著者Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
登録日2018-08-24
公開日2018-12-05
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019