Author results

7JJO
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STRUCTURAL BASIS OF THE ACTIVATION OF HETEROTRIMERIC GS-PROTEIN BY ISOPROTERENOL-BOUND BETA1-ADRENERGIC RECEPTOR
分子名称:Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Su, M., Zhu, L., Zhang, Y., Paknejad, N., Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J.R., Hite, R.K., Walz, T., Liu, W., Huang, X.Y.
登録日2020-07-27
公開日2020-09-02
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor.
Mol.Cell, 80, 2020
7BR2
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BT4096 A GUT MICROBIAL DILTIAZEM-METABOLIZING ENZYME
分子名称:Lipolytic enzyme, G-D-S-L family
著者Ko, T.-P., Chen, C.-C., Guo, R.-T.
登録日2020-03-26
公開日2020-05-06
最終更新日2020-06-17
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structure of a gut microbial diltiazem-metabolizing enzyme suggests possible substrate binding mode.
Biochem.Biophys.Res.Commun., 527, 2020
7BQW
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM FUSOBACTERIUM NUCLEATUM
分子名称:L-methionine gamma-lyase
著者Lan, J., Chen, Y., Liu, W., Xu, Y.
登録日2020-03-25
公開日2020-04-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum
To Be Published
7BPC
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CRYSTAL STRUCTURE OF 2, 3-DIHYDROXYBENZOIC ACID DECARBOXYLASE FROM FUSARIUM OXYSPORUM IN COMPLEX WITH 2,5-DHBA
分子名称:2,3-dihydroxybenzoate decarboxylase, 2,5-dihydroxybenzoic acid, ZINC ION
著者Song, M.K., Feng, J.H., Liu, W.D., Wu, Q.Q., Zhu, D.M.
登録日2020-03-22
公開日2020-07-15
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem, 2020
7BP1
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CRYSTAL STRUCTURE OF 2, 3-DIHYDROXYBENZOIC ACID DECARBOXYLASE FROM FUSARIUM OXYSPORUM IN COMPLEX WITH CATECHOL
分子名称:2,3-dihydroxybenzoate decarboxylase, CATECHOL, ZINC ION
著者Song, M.K., Feng, J.H., Liu, W.D., Wu, Q.Q., Zhu, D.M.
登録日2020-03-21
公開日2020-07-15
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem, 2020
6YQ6
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PROMISCUOUS REDUCTASE LUGOII CATALYZES KETO-REDUCTION AT C1 DURING LUGDUNOMYCIN BIOSYNTHESIS
分子名称:Monooxygenase, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
著者Xiao, X., Elsayed, S.S., Wu, C., van der Heul, H., Prota, A., Huang, J., Guo, R., Abrahams, J.P., van Wezel, G.P.
登録日2020-04-16
公開日2020-09-16
最終更新日2020-09-30
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 15, 2020
6YQ3
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PROMISCUOUS REDUCTASE LUGOII CATALYZES KETO-REDUCTION AT C1 DURING LUGDUNOMYCIN BIOSYNTHESIS
分子名称:Monooxygenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3~{R})-8-methoxy-3-methyl-3,6-bis(oxidanyl)-2,4-dihydrobenzo[a]anthracene-1,7,12-trione, ...
著者Xiao, X., Elsayed, S.S., Wu, C., van der Heul, H., Prota, A., Huang, J., Guo, R., Abrahams, J.P., van Wezel, G.P.
登録日2020-04-16
公開日2020-09-16
最終更新日2020-09-30
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 15, 2020
6YQ0
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PROMISCUOUS REDUCTASE LUGOII CATALYZES KETO-REDUCTION AT C1 DURING LUGDUNOMYCIN BIOSYNTHESIS
分子名称:Monooxygenase, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Xiao, X., Elsayed, S.S., Wu, C., van der Heul, H., Prota, A., Huang, J., Guo, R., Abrahams, J.P., van Wezel, G.P.
登録日2020-04-16
公開日2020-09-16
最終更新日2020-09-30
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 15, 2020
6YPZ
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PROMISCUOUS REDUCTASE LUGOII CATALYZES KETO-REDUCTION AT C1 DURING LUGDUNOMYCIN BIOSYNTHESIS
分子名称:Monooxygenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ...
著者Xiao, X., Elsayed, S.S., Wu, C., van der Heul, H., Prota, A., Huang, J., Guo, R., Abrahams, J.P., van Wezel, G.P.
登録日2020-04-16
公開日2020-09-16
最終更新日2020-09-30
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 15, 2020
6W8T
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CRYSTAL STRUCTURE OF METACASPASE 4 FROM ARABIDOPSIS (MICROCRYSTALS TREATED WITH CALCIUM)
分子名称:Metacaspase-4, SULFATE ION
著者Zhu, P., Yu, X.H., Wang, C., Zhang, Q., Liu, W., McSweeney, S., Shanklin, J., Lam, E., Liu, Q.
登録日2020-03-21
公開日2020-05-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for Ca2+-dependent activation of a plant metacaspase.
Nat Commun, 11, 2020
6W8S
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CRYSTAL STRUCTURE OF METACASPASE 4 FROM ARABIDOPSIS
分子名称:Metacaspase-4, SULFATE ION
著者Zhu, P., Yu, X.H., Wang, C., Zhang, Q., Liu, W., McSweeney, S., Shanklin, J., Lam, E., Liu, Q.
登録日2020-03-21
公開日2020-05-20
実験手法X-RAY DIFFRACTION (3.484 Å)
主引用文献Structural basis for Ca2+-dependent activation of a plant metacaspase.
Nat Commun, 11, 2020
6W8R
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CRYSTAL STRUCTURE OF METACASPASE 4 C139A FROM ARABIDOPSIS
分子名称:Metacaspase-4, SULFATE ION
著者Zhu, P., Yu, X.H., Wang, C., Zhang, Q., Liu, W., McSweeney, S., Shanklin, J., Lam, E., Liu, Q.
登録日2020-03-21
公開日2020-05-20
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Structural basis for Ca2+-dependent activation of a plant metacaspase.
Nat Commun, 11, 2020
6W2E
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STRUCTURES OF CAPSID AND CAPSID-ASSOCIATED TEGUMENT COMPLEX INSIDE THE EPSTEIN-BARR VIRUS
分子名称:Major capsid protein, Capsid vertex component 1, Capsid vertex component 2, ...
著者Liu, W., Cui, Y.X., Wang, C.Y., Li, Z.H., Gong, D.Y., Dai, X.H., Bi, G.Q., Sun, R., Zhou, Z.H.
登録日2020-03-05
公開日2020-07-15
最終更新日2020-10-07
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Nat Microbiol, 5, 2020
6W2D
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STRUCTURES OF CAPSID AND CAPSID-ASSOCIATED TEGUMENT COMPLEX INSIDE THE EPSTEIN-BARR VIRUS
分子名称:Major capsid protein, Capsid vertex component 1, Capsid vertex component 2, ...
著者Liu, W., Cui, Y.X., Wang, C.Y., Li, Z.H., Gong, D.Y., Dai, X.H., Bi, G.Q., Sun, R., Zhou, Z.H.
登録日2020-03-05
公開日2020-07-15
最終更新日2020-10-07
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Nat Microbiol, 5, 2020
6W19
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STRUCTURES OF CAPSID AND CAPSID-ASSOCIATED TEGUMENT COMPLEX INSIDE THE EPSTEIN-BARR VIRUS
分子名称:Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ...
著者Liu, W., Cui, Y.X., Wang, C.Y., Li, Z.H., Gong, D.Y., Dai, X.H., Bi, G.Q., Sun, R., Zhou, Z.H.
登録日2020-03-03
公開日2020-07-15
最終更新日2020-10-07
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus.
Nat Microbiol, 5, 2020
6VBN
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CRYSTAL STRUCTURE OF HTDO2 BOUND TO INHIBITOR GNE1
分子名称:Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol
著者Harris, S.F., Oh, A.
登録日2019-12-19
公開日2020-05-06
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Acs Med.Chem.Lett., 11, 2020
6RZ5
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XFEL CRYSTAL STRUCTURE OF THE HUMAN CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH ZAFIRLUKAST
分子名称:Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, zafirlukast, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Luginina, A., Gusach, A., Marin, E., Mishin, A., Brouillette, R., Popov, P., Shiryaeva, A., Besserer-Offroy, E., Longpre, J.M., Lyapina, E., Ishchenko, A., Patel, N., Polovinkin, V., Safronova, N., Bogorodskiy, A., Edelweiss, E., Liu, W., Batyuk, A., Gordeliy, V., Han, G.W., Sarret, P., Katritch, V., Borshchevskiy, V., Cherezov, V.
登録日2019-06-12
公開日2019-10-30
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
6RZ4
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CRYSTAL STRUCTURE OF CYSTEINYL LEUKOTRIENE RECEPTOR 1 IN COMPLEX WITH PRANLUKAST
分子名称:Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, pranlukast, SODIUM ION, ...
著者Luginina, A., Gusach, A., Marin, E., Mishin, A., Brouillette, R., Popov, P., Shiryaeva, A., Besserer-Offroy, E., Longpre, J.M., Lyapina, E., Ishchenko, A., Patel, N., Polovinkin, V., Safronova, N., Bogorodskiy, A., Edelweiss, E., Liu, W., Batyuk, A., Gordeliy, V., Han, G.W., Sarret, P., Katritch, V., Borshchevskiy, V., Cherezov, V.
登録日2019-06-12
公開日2019-10-30
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
6Q1F
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ATOMIC STRUCTURE OF THE HUMAN HERPESVIRUS 6B CAPSID AND CAPSID-ASSOCIATED TEGUMENT COMPLEXES
分子名称:Major capsid protein, Large structural phosphoprotein, Small capsomere-interacting protein, ...
著者Zhang, Y.B., Liu, W., Li, Z.H., Kumar, V., Alvarez-Cabrera, A.L., Leibovitch, E., Cui, Y.X., Mei, Y., Bi, G.Q., Jacobson, S., Zhou, Z.H.
登録日2019-08-03
公開日2019-12-11
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes.
Nat Commun, 10, 2019
6PS8
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XFEL MT1R STRUCTURE BY LIGAND EXCHANGE FROM AGOMELATINE TO 2-PHENYLMELATONIN.
分子名称:Fusion protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
6PS7
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XFEL A2AR STRUCTURE BY LIGAND EXCHANGE FROM LUF5843 TO ZM241385.
分子名称:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
6PS6
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XFEL BETA2 AR STRUCTURE BY LIGAND EXCHANGE FROM TIMOLOL TO TIMOLOL.
分子名称:Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, SULFATE ION, ...
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
6PS5
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XFEL BETA2 AR STRUCTURE BY LIGAND EXCHANGE FROM TIMOLOL TO PROPRANOLOL.
分子名称:Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, 1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL, SULFATE ION, ...
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
6PS4
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XFEL BETA2 AR STRUCTURE BY LIGAND EXCHANGE FROM TIMOLOL TO ICI-118551.
分子名称:Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, SULFATE ION, ...
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
6PS3
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XFEL BETA2 AR STRUCTURE BY LIGAND EXCHANGE FROM TIMOLOL TO CARVEDILOL.
分子名称:Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme, (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, SULFATE ION, ...
著者Ishchenko, A., Stauch, B., Han, G.W., Batyuk, A., Shiriaeva, A., Li, C., Zatsepin, N.A., Weierstall, U., Liu, W., Nango, E., Nakane, T., Tanaka, R., Tono, K., Joti, Y., Iwata, S., Moraes, I., Gati, C., Cherezov, C.
登録日2019-07-12
公開日2019-11-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Toward G protein-coupled receptor structure-based drug design using X-ray lasers.
Iucrj, 6, 2019
170172
件を2020-10-21に公開中