Author results

5TDH
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THE CRYSTAL STRUCTURE OF THE DOMINANT NEGATIVE MUTANT G PROTEIN ALPHA(I)-1-BETA-1-GAMMA-2 G203A/A326S
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, P., Jia, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher, K., Xu, H.E., Jiang, Y.
Deposit date:2016-09-19
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer
Acta Pharmacol.Sin., 37, 2016
1TQH
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COVALENT REACTION INTERMEDIATE REVEALED IN CRYSTAL STRUCTURE OF THE GEOBACILLUS STEAROTHERMOPHILUS CARBOXYLESTERASE EST30
Descriptor:Carboxylesterase precursor, SULFATE ION, PROPYL ACETATE
Authors:Liu, P., Wang, Y.F., Ewis, H.E., Abdelal, A.T., Lu, C.D., Harrison, R.W., Weber, I.T.
Deposit date:2004-06-17
Release date:2004-09-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.
J.Mol.Biol., 342, 2004
2OGS
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CRYSTAL STRUCTURE OF THE GEOBACILLUS STEAROTHERMOPHILUS CARBOXYLESTERASE EST55 AT PH 6.2
Descriptor:Thermostable carboxylesterase Est50, IODIDE ION
Authors:Liu, P., Ewis, H.E., Tai, P.C., Lu, C.D., Weber, I.T.
Deposit date:2007-01-08
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11.
J.Mol.Biol., 367, 2007
2OGT
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CRYSTAL STRUCTURE OF THE GEOBACILLUS STEAROTHERMOPHILUS CARBOXYLESTERASE EST55 AT PH 6.8
Descriptor:Thermostable carboxylesterase Est50, IODIDE ION, GLYCEROL
Authors:Liu, P., Ewis, H.E., Tai, P.C., Lu, C.D., Weber, I.T.
Deposit date:2007-01-08
Release date:2007-02-13
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11.
J.Mol.Biol., 367, 2007
2R9B
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STRUCTURAL ANALYSIS OF PLASMEPSIN 2 FROM PLASMODIUM FALCIPARUM COMPLEXED WITH A PEPTIDE-BASED INHIBITOR
Descriptor:Plasmepsin-2, peptide-based inhibitor
Authors:Liu, P., Marzahn, M.R., Robbins, A.H., McKenna, R., Dunn, B.M.
Deposit date:2007-09-12
Release date:2007-11-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
Biochemistry, 48, 2009
2RCV
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CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS SUPEROXIDE DISMUTASE
Descriptor:Superoxide dismutase [Mn], MANGANESE (II) ION
Authors:Liu, P., Ewis, H.E., Huang, Y.J., Lu, C.D., Tai, P.C., Weber, I.T.
Deposit date:2007-09-20
Release date:2008-02-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Bacillus subtilis superoxide dismutase.
Acta Crystallogr.,Sect.F, 63, 2007
3U2P
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CRYSTAL STRUCTURE OF N-TERMINAL THREE EXTRACELLULAR DOMAINS OF ERBB4/HER4
Descriptor:Receptor tyrosine-protein kinase erbB-4, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, P., Bouyain, S., Elgenbrot, C., Leahy, D.J.
Deposit date:2011-10-04
Release date:2011-11-09
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.
Protein Sci., 21, 2012
3U7U
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CRYSTAL STRUCTURE OF EXTRACELLULAR REGION OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 4 IN COMPLEX WITH NEUREGULIN-1 BETA
Descriptor:Receptor tyrosine-protein kinase erbB-4, Neuregulin 1, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, P., Cleveland IV, T.E., Bouyain, S., Longo, P.A., Leahy, D.J.
Deposit date:2011-10-14
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:A single ligand is sufficient to activate EGFR dimers.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQ1
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CRYSTAL STRUCTURE OF AN LRR PROTEIN WITH TWO SOLENOIDS
Descriptor:Probable receptor protein kinase TMK1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Chai, J., Liu, P., Hu, Z., Zhou, B., Liu, S.
Deposit date:2012-10-25
Release date:2013-05-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of an LRR protein with two solenoids
Cell Res., 23, 2013
5V54
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CRYSTAL STRUCTURE OF 5-HT1B RECEPTOR IN COMPLEX WITH METHIOTHEPIN
Descriptor:5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Authors:Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
Deposit date:2017-03-13
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Cell Discov, 2018
1REO
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L-AMINO ACID OXIDASE FROM AGKISTRODON HALYS PALLAS
Descriptor:AHPLAAO, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Zhang, H., Teng, M., Niu, L., Wang, Y., Wang, Y., Liu, Q., Huang, Q., Hao, Q., Dong, Y., Liu, P.
Deposit date:2003-11-07
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom.
Acta Crystallogr.,Sect.D, 60, 2004
1ZZ6
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CRYSTAL STRUCTURE OF APO-HPPE
Descriptor:Hydroxypropylphosphonic Acid Epoxidase
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
1ZZ7
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CRYSTAL STRUCTURE OF FEII HPPE IN COMPLEX WITH SUBSTRATE FORM 1
Descriptor:Hydroxyprophylphosphonic Acid Epoxidase, FE (II) ION, (S)-2-HYDROXYPROPYLPHOSPHONIC ACID
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
1ZZ8
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CRYSTAL STRUCTURE OF FEII HPPE IN COMPLEX WITH SUBSTRATE FORM 2
Descriptor:Hydroxypropylphosphonic Acid Epoxidase, FE (II) ION, (S)-2-HYDROXYPROPYLPHOSPHONIC ACID
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
1ZZ9
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CRYSTAL STRUCTURE OF FEII HPPE
Descriptor:Hydroxypropylphosphonic Acid Epoxidase, FE (II) ION, SULFATE ION
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
1ZZB
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CRYSTAL STRUCTURE OF COII HPPE IN COMPLEX WITH SUBSTRATE
Descriptor:Hydroxypropylphosphonic Acid Epoxidase, COBALT (II) ION, (S)-2-HYDROXYPROPYLPHOSPHONIC ACID
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
1ZZC
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CRYSTAL STRUCTURE OF COII HPPE IN COMPLEX WITH TRIS BUFFER
Descriptor:hydroxypropylphosphonic acid epoxidase, COBALT (II) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Higgins, L.J., Yan, F., Liu, P., Liu, H.W., Drennan, C.L.
Deposit date:2005-06-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature, 437, 2005
5DO2
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COMPLEX STRUCTURE OF MERS-RBD BOUND WITH 4C2 ANTIBODY
Descriptor:S protein, 4C2 heavy chain, 4C2 light chain, ...
Authors:Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Yuen, K.Y., Perlman, S., Gao, G.F., Yan, J.
Deposit date:2015-09-10
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.
Cell Res., 25, 2015
3U9U
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CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF HUMAN ERBB4/HER4 IN COMPLEX WITH THE FAB FRAGMENT OF MAB1479
Descriptor:Fab Heavy Chain, Fab Light Chain, Receptor tyrosine-protein kinase erbB-4
Authors:Hollmen, M., Liu, P., Wildiers, H., Reinvall, I., Vandorpe, T., Smeets, A., Deraedt, K., Vahlberg, T., Joensuu, H., Leahy, D.J., Schoffski, P., Elenius, K.
Deposit date:2011-10-19
Release date:2012-10-31
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Proteolytic processing of ErbB4 in breast cancer.
Plos One, 7, 2012
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
3FN3
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DIMERIC STRUCTURE OF PD-L1
Descriptor:Programmed cell death 1 ligand 1
Authors:Chen, Y., Gao, F., Liu, P., Chu, F., Qi, J., Gao, G.F.
Deposit date:2008-12-23
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dimeric structure of PD-L1: functional units or evolutionary relics?
Protein Cell, 1, 2010
3VCA
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QUATERNARY AMMONIUM OXIDATIVE DEMETHYLATION: X-RAY CRYSTALLOGRAPHIC, RESONANCE RAMAN AND UV-VISIBLE SPECTROSCOPIC ANALYSIS OF A RIESKE-TYPE DEMETHYLASE
Descriptor:Ring-hydroxylating dioxygenase, FE2/S2 (INORGANIC) CLUSTER, FE (III) ION, ...
Authors:Daughtry, K.D., Xiao, Y., Stoner-Ma, D., Cho, E., Orville, A.M., Liu, P., Allen, K.N.
Deposit date:2012-01-03
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman, and UV-Visible Spectroscopic Analysis of a Rieske-Type Demethylase.
J.Am.Chem.Soc., 134, 2012
3VCP
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THE 2.2 ANGSTROM STRUCTURE OF STC2 WITH PROLINE BOUND IN THE ACTIVE SITE
Descriptor:Ring-hydroxylating dioxygenase, FE2/S2 (INORGANIC) CLUSTER, FE (III) ION, ...
Authors:Daughtry, K.D., Xiao, Y., Stoner-Ma, D., Cho, E., Orville, A.M., Liu, P., Allen, K.N.
Deposit date:2012-01-04
Release date:2012-02-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman, and UV-Visible Spectroscopic Analysis of a Rieske-Type Demethylase.
J.Am.Chem.Soc., 134, 2012
5F81
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Lysozyme C, SODIUM ION, CHLORIDE ION
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2015-12-08
Release date:2016-02-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016
5HL4
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ACOUSTIC INJECTORS FOR DROP-ON-DEMAND SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Ring-hydroxylating dioxygenase, FE2/S2 (INORGANIC) CLUSTER, FE (III) ION, ...
Authors:Roessler, C.G., Agarwal, R., Allaire, M., Alonso-Mori, R., Andi, B., Bachega, J.F.R., Bommer, M., Brewster, A.S., Browne, M.C., Chatterjee, R., Cho, E., Cohen, A.E., Cowan, M., Datwani, S., Davidson, V.L., Defever, J., Eaton, B., Ellson, R., Feng, Y., Ghislain, L.P., Glownia, J.M., Han, G., Hattne, J., Hellmich, J., Heroux, A., Ibrahim, M., Kern, J., Kuczewski, A., Lemke, H.T., Liu, P., Majlof, L., McClintock, W.M., Myers, S., Nelsen, S., Olechno, J., Orville, A.M., Sauter, N.K., Soares, A.S., Soltis, M.S., Song, H., Stearns, R.G., Tran, R., Tsai, Y., Uervirojnangkoorn, M., Wilmot, C.M., Yachandra, V., Yano, J., Yukl, E.T., Zhu, D., Zouni, A.
Deposit date:2016-01-14
Release date:2016-01-27
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.
Structure, 24, 2016