Author results

5GRJ
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CRYSTAL STRUCTURE OF HUMAN PD-L1 WITH MONOCLONAL ANTIBODY AVELUMAB
Descriptor:avelumab H chain, avelumab L chain, Programmed cell death 1 ligand 1
Authors:Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C.W.-H., Shi, Y., Liu, J., Tan, W., Lyu, J., Gao, S., Yan, J., Qi, J., Gao, G.F.
Deposit date:2016-08-11
Release date:2016-11-02
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (3.206 Å)
Cite:Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.
Cell Res., 27, 2017
4QRH
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MOLECULAR MECHANISM AND EVOLUTION OF GUANYLATE KINASE REGULATION BY (P)PPGPP
Descriptor:Guanylate kinase, SULFATE ION, MAGNESIUM ION, ...
Authors:Liu, K., Krasny, K., Myers, A.R., Satyshur, K.A., Keck, J.L., Wnag, J.D.
Deposit date:2014-07-01
Release date:2015-02-25
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp.
Mol.Cell, 57, 2015
6C1A
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ...
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-04
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1Y
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MBD OF HUMAN MECP2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Bian, C., Tempel, W., Wernimont, A.K., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:mbd of human mecp2 in complex with methylated DNA
to be published
6C2F
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-01-08
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MBD2 in complex with methylated DNA
to be published
6CC8
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
Descriptor:Methyl-CpG-binding domain protein 3, methylated CpG DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-06
Release date:2018-04-04
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CCG
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
Descriptor:Methyl-CpG-binding domain protein 3, DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-07
Release date:2018-05-09
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CEU
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
Descriptor:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
Authors:Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CEV
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
Descriptor:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
Authors:Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CNQ
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6D1T
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COMPLEX OF MBD1-MBD AND METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 1, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-04-12
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Complex of MBD1-MBD and methylated DNA
to be published
5GR7
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MOUSE MHC CLASS I H-2KD WITH A MERS-COV-DERIVED PEPTIDE 37-1
Descriptor:H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, ...
Authors:Liu, K., Chai, Y., Qi, J., Tan, W., Liu, W.J., Gao, G.F.
Deposit date:2016-08-08
Release date:2017-06-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
5GSB
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MOUSE MHC CLASS I H-2KD WITH A MERS-COV-DERIVED PEPTIDE 37-3
Descriptor:H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, ...
Authors:Liu, K., Chai, Y., Qi, J., Tan, W., Liu, W.J., Gao, G.F.
Deposit date:2016-08-15
Release date:2017-07-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
5GSR
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MOUSE MHC CLASS I H-2KD WITH A MERS-COV-DERIVED PEPTIDE I5A
Descriptor:Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ...
Authors:Liu, K., Chai, Y., Qi, J., Tan, W., Liu, W.J., Gao, G.F.
Deposit date:2016-08-17
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
5GSV
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MOUSE MHC CLASS I H-2KD WITH A MERS-COV-DERIVED PEPTIDE 142-5
Descriptor:H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, ...
Authors:Liu, K., Chai, Y., Qi, J., Tan, W., Liu, W.J., Gao, G.F.
Deposit date:2016-08-17
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
5GSX
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MOUSE MHC CLASS I H-2KD WITH A MERS-COV-DERIVED PEPTIDE 142-2
Descriptor:H-2 class I histocompatibility antigen, K-D alpha chain, Beta-2-microglobulin, ...
Authors:Liu, K., Chai, Y., Qi, J., Tan, W., Liu, W.J., Gao, G.F.
Deposit date:2016-08-17
Release date:2017-06-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
3OMC
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STRUCTURE OF HUMAN SND1 EXTENDED TUDOR DOMAIN IN COMPLEX WITH THE SYMMETRICALLY DIMETHYLATED ARGININE PIWIL1 PEPTIDE R4ME2S
Descriptor:Staphylococcal nuclease domain-containing protein 1, SYNTHETIC PEPTIDE, CHLORIDE ION
Authors:Lam, R., Liu, K., Guo, Y.H., Bian, C.B., Xu, C., MacKenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2010-08-26
Release date:2010-09-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OMG
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STRUCTURE OF HUMAN SND1 EXTENDED TUDOR DOMAIN IN COMPLEX WITH THE SYMMETRICALLY DIMETHYLATED ARGININE PIWIL1 PEPTIDE R14ME2S
Descriptor:Staphylococcal nuclease domain-containing protein 1, dimethylated arginine peptide R14me2s
Authors:Lam, R., Liu, K., Guo, Y.H., Bian, C.B., Xu, C., MacKenzie, F., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2010-08-26
Release date:2010-09-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.
Proc.Natl.Acad.Sci.USA, 107, 2010
4O64
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ZINC FINGERS OF KDM2B
Descriptor:Lysine-specific demethylase 2B, ZINC ION, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-20
Release date:2014-04-16
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4Z3C
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ZINC FINGER REGION OF HUMAN TET3 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Dong, A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-03-31
Release date:2015-04-29
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
5VC9
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ZINC FINGER OF HUMAN CXXC4 IN COMPLEX WITH CPG DNA
Descriptor:CpG DNA, CXXC-type zinc finger protein 4, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-03-31
Release date:2017-06-28
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
5W9Q
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ZINC FINGER REGION OF MBD1 IN COMPLEX WITH CPG DNA
Descriptor:Methyl-CpG-binding domain protein 1, dna, ZINC ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-23
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
5W9S
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ZINC FINGER OF HUMAN CXXC5 IN COMPLEX WITH CPG DNA
Descriptor:CpG DNA fragment, CXXC-type zinc finger protein 5, ZINC ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-23
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6ASB
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CXXC AND PHD-TYPE ZINC FINGER REGIONS OF FBXL19 IN COMPLEX WITH DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), F-box/LRR-repeat protein 19, ZINC ION
Authors:Liu, K., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
6ASD
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ZINC FINGER REGION OF HUMAN TET1 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase TET1, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-24
Release date:2017-10-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018