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6NY3
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BU of 6ny3 by Molmil
CasX ternary complex with 30bp target DNA
Descriptor: CasX, DNA Non-target strand, DNA target strand, ...
Authors:Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
Deposit date:2019-02-10
Release date:2019-02-27
Last modified:2019-12-25
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
6NY2
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BU of 6ny2 by Molmil
CasX-gRNA-DNA(45bp) state I
Descriptor: CasX, DNA Non-target strand, DNA target strand, ...
Authors:Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
Deposit date:2019-02-10
Release date:2019-02-27
Last modified:2019-12-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
6NY1
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BU of 6ny1 by Molmil
CasX-gRNA-DNA(30bp) State II
Descriptor: CasX, DNA Non-target strand, DNA target strand, ...
Authors:Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
Deposit date:2019-02-10
Release date:2019-02-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
3LE6
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BU of 3le6 by Molmil
The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor
Descriptor: 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine, Cell division protein kinase 2
Authors:Lukacs, C.M, Swain, A, Crowther, R.L, Kammlott, R.U, Liu, J.J.
Deposit date:2010-01-14
Release date:2010-11-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
6O1O
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BU of 6o1o by Molmil
Cryo-EM structure of the T. thermophilus Csm complex bound to target ssRNA
Descriptor: Csm1, Csm2, Csm3, ...
Authors:Liu, J.J, Liu, T.Y.
Deposit date:2019-02-21
Release date:2019-07-10
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble.
Nat Commun, 10, 2019
6P7M
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BU of 6p7m by Molmil
Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex)
Descriptor: Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ...
Authors:Knott, G.J, Liu, J.J, Doudna, J.A.
Deposit date:2019-06-06
Release date:2019-08-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
6P7N
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BU of 6p7n by Molmil
Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex)
Descriptor: Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ...
Authors:Knott, G.J, Liu, J.J, Doudna, J.A.
Deposit date:2019-06-06
Release date:2019-08-21
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
3U7D
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BU of 3u7d by Molmil
Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail
Descriptor: Krev interaction trapped protein 1, Protein HEG homolog 1
Authors:Gingras, A.R, Liu, J.J, Ginsberg, M.H, Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT)
Deposit date:2011-10-13
Release date:2012-09-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
5YFP
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BU of 5yfp by Molmil
Cryo-EM Structure of the Exocyst Complex
Descriptor: Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ...
Authors:Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W.
Deposit date:2017-09-21
Release date:2018-01-31
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structure of the exocyst complex
Nat. Struct. Mol. Biol., 25, 2018
5VZL
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BU of 5vzl by Molmil
cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex
Descriptor: CRISPR-associated endonuclease Cas9, phage anti-CRISPR AcrIIA4, single guide RNA (116-MER)
Authors:Jiang, F, Liu, J.J, Nogales, E, Doudna, J.A.
Deposit date:2017-05-29
Release date:2017-07-26
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Disabling Cas9 by an anti-CRISPR DNA mimic.
Sci Adv, 3, 2017
5WFE
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BU of 5wfe by Molmil
Cas1-Cas2-IHF-DNA holo-complex
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
Authors:Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A.
Deposit date:2017-07-11
Release date:2017-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structures of the CRISPR genome integration complex.
Science, 357, 2017
6MCC
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BU of 6mcc by Molmil
CryoEM structure of AcrIIA2 homolog in complex with CRISPR-Cas9
Descriptor: Anti-CRISPR AcrIIA2 Homolog, CRISPR-associated endonuclease Cas9, Single guide RNA (116-MER)
Authors:Jiang, F, Liu, J.J, Doudna, J.A.
Deposit date:2018-08-31
Release date:2019-01-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Mol. Cell, 73, 2019
6MCB
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BU of 6mcb by Molmil
CryoEM structure of AcrIIA2 in complex with CRISPR-Cas9
Descriptor: Anti-CRISPR protein AcrIIA2, CRISPR-associated endonuclease Cas9, Single guide RNA (116-MER)
Authors:Jiang, F, Liu, J.J, Doudna, J.A.
Deposit date:2018-08-31
Release date:2019-01-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Mol. Cell, 73, 2019
5G06
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BU of 5g06 by Molmil
Cryo-EM structure of yeast cytoplasmic exosome
Descriptor: EXOSOME COMPLEX COMPONENT CSL4, EXOSOME COMPLEX COMPONENT MTR3, EXOSOME COMPLEX COMPONENT RRP4, ...
Authors:Liu, J.J, Niu, C.Y, Wu, Y, Tan, D, Wang, Y, Ye, M.D, Liu, Y, Zhao, W.W, Zhou, K, Liu, Q.S, Dai, J.B, Yang, X.R, Dong, M.Q, Huang, N, Wang, H.W.
Deposit date:2016-03-17
Release date:2016-06-15
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
4QOC
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BU of 4qoc by Molmil
crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid
Authors:Huang, X.
Deposit date:2014-06-19
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Bioorg.Med.Chem.Lett., 24, 2014
4QO4
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BU of 4qo4 by Molmil
co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-cyclopropylpyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid
Authors:Huang, X.
Deposit date:2014-06-19
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
ACS Med Chem Lett, 5, 2014
4J3E
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BU of 4j3e by Molmil
The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Graves, B.J, Lukacs, C.M, Kammlott, R.U, Crowther, R.
Deposit date:2013-02-05
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
5GRS
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BU of 5grs by Molmil
Complex structure of the fission yeast SREBP-SCAP binding domains
Descriptor: Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein
Authors:Gong, X, Qian, H.W, Wu, J.P, Yan, N.
Deposit date:2016-08-12
Release date:2016-12-14
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
5GPD
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BU of 5gpd by Molmil
Crystal structure of the binding domain of SREBP from fission yeast
Descriptor: Sterol regulatory element-binding protein 1
Authors:Gong, X, Qian, H.W, Wu, J.P, Yan, N.
Deposit date:2016-08-01
Release date:2016-11-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
8IBW
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BU of 8ibw by Molmil
Structure of R2 with 3'UTR and DNA in binding state
Descriptor: 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ...
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBX
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BU of 8ibx by Molmil
Structure of R2 with 3'UTR and DNA in unwinding state
Descriptor: 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ...
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBZ
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BU of 8ibz by Molmil
Structure of R2 with 5'ORF and 3'UTR
Descriptor: 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
8IBY
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BU of 8iby by Molmil
Structure of R2 with 5'ORF
Descriptor: 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION
Authors:Deng, P, Tan, S, Wang, J, Liu, J.J.
Deposit date:2023-02-10
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
5EJ9
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BU of 5ej9 by Molmil
EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min
Descriptor: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, GLYCEROL, ...
Authors:Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H.
Deposit date:2015-11-01
Release date:2016-06-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
J.Am.Chem.Soc., 138, 2016
5EJA
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BU of 5eja by Molmil
EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7 min
Descriptor: (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, ...
Authors:Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H.
Deposit date:2015-11-01
Release date:2016-06-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
J.Am.Chem.Soc., 138, 2016

 

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