Author results

5ZHP
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M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST
Descriptor:Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ...
Authors:Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P.
Deposit date:2018-03-13
Release date:2018-11-28
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ET0
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CRYSTAL STRUCTURE OF MYO3B-ARB2 IN COMPLEX WITH ESPIN1-AR
Descriptor:Espin, Myosin-IIIb
Authors:Liu, H., Li, J., Liu, W., Zhang, M.
Deposit date:2015-11-17
Release date:2016-02-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
5ET1
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CRYSTAL STRUCTURE OF MYO3B-ARB1 IN COMPLEX WITH ESPIN1-AR
Descriptor:Espin, Myosin-IIIb, GLYCEROL
Authors:Liu, H., Li, J., liu, W., Zhang, M.
Deposit date:2015-11-17
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
3CYV
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CRYSTAL STRUCTURE OF UROPORPHYRINOGEN DECARBOXYLASE FROM SHIGELLA FLEXINERI: NEW INSIGHTS INTO ITS CATALYTIC MECHANISM
Descriptor:Uroporphyrinogen decarboxylase
Authors:Liu, H., Zhou, H., Bi, R.
Deposit date:2008-04-26
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of uroporphyrinogen III decarboxylase from Shigella flexineri: new insights into its catalytic mechanism
To be Published
4EXN
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CRYSTAL STRUCTURE OF MOUSE INTERLEUKIN-34
Descriptor:Interleukin-34, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Liu, H., Leo, C., Chen, X., Wong, B.R., Williams, L.T., Lin, H., He, X.
Deposit date:2012-04-30
Release date:2012-05-30
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
4EXP
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STRUCTURE OF MOUSE INTERLEUKIN-34 IN COMPLEX WITH MOUSE FMS
Descriptor:Interleukin-34, Macrophage colony-stimulating factor 1 receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, H., Leo, C., Chen, X., Wong, B.R., Williams, L.T., Lin, H., He, X.
Deposit date:2012-04-30
Release date:2012-05-30
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
4FI1
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CRYSTAL STRUCTURE OF SCCK2 ALPHA IN COMPLEX WITH ATP
Descriptor:Casein kinase II subunit alpha, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Liu, H., Wang, H., Teng, M., Li, X.
Deposit date:2012-06-07
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of scCK2 alpha in complex with ATP
To be Published
4JQE
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CRYSTAL STRUCTURE OF SCCK2 ALPHA IN COMPLEX WITH AMPPN
Descriptor:Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Liu, H.
Deposit date:2013-03-20
Release date:2014-03-05
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4JR7
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CRYSTAL STRUCTURE OF SCCK2 ALPHA IN COMPLEX WITH GMPPNP
Descriptor:Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Liu, H.
Deposit date:2013-03-21
Release date:2014-03-05
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4LFI
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CRYSTAL STRUCTURE OF SCCK2 ALPHA IN COMPLEX WITH GMPPNP
Descriptor:Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MANGANESE (II) ION, ...
Authors:Liu, H.
Deposit date:2013-06-27
Release date:2014-03-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4MWH
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CRYSTAL STRUCTURE OF SCCK2 ALPHA IN COMPLEX WITH ATP
Descriptor:Casein kinase II subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Liu, H.
Deposit date:2013-09-24
Release date:2013-11-20
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
6C1Q
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CRYSTAL STRUCTURE OF HUMAN C5A RECEPTOR IN COMPLEX WITH AN ORTHOSTERIC ANTAGONIST PMX53 AND AN ALLOSTERIC ANTAGONIST NDT9513727
Descriptor:Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera, PMX53, ...
Authors:Liu, H., Wang, L., Wei, Z., Zhang, C.
Deposit date:2018-01-05
Release date:2018-05-30
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Orthosteric and allosteric action of the C5a receptor antagonists.
Nat. Struct. Mol. Biol., 25, 2018
6C1R
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CRYSTAL STRUCTURE OF HUMAN C5A RECEPTOR IN COMPLEX WITH AN ORTHOSTERIC ANTAGONIST PMX53 AND AN ALLOSTERIC ANTAGONIST AVACOPAN
Descriptor:Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera, PMX53, ...
Authors:Liu, H., Wang, L., Wei, Z., Zhang, C.
Deposit date:2018-01-05
Release date:2018-05-30
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Orthosteric and allosteric action of the C5a receptor antagonists.
Nat. Struct. Mol. Biol., 25, 2018
1MY9
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SOLUTION STRUCTURE OF A K+ CATION STABILIZED DIMERIC RNA QUADRUPLEX CONTAINING TWO G:G(:A):G:G(:A) HEXADS, G:G:G:G TETRADS AND UUUU LOOPS
Descriptor:5'-R(*GP*GP*AP*GP*GP*UP*UP*UP*UP*GP*GP*AP*GP*G)-3'
Authors:Liu, H., Matsugami, A., Katahira, M., Uesugi, S.
Deposit date:2002-10-04
Release date:2003-10-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Dimeric RNA Quadruplex Architecture Comprised of Two G:G(:A):G:G(:A) Hexads, G:G:G:G Tetrads and UUUU Loops
J.Mol.Biol., 322, 2002
2JBM
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QPRTASE STRUCTURE FROM HUMAN
Descriptor:NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE, S,R MESO-TARTARIC ACID
Authors:Liu, H., Naismith, J.H.
Deposit date:2006-12-08
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Quinolinate Phosphoribosyltransferase (Hqprtase) from Homo Sapiens.
J.Mol.Biol., 373, 2007
2O26
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STRUCTURE OF A CLASS III RTK SIGNALING ASSEMBLY
Descriptor:Kit ligand, Mast/stem cell growth factor receptor, BETA-L-FUCOSE, ...
Authors:Liu, H., Chen, X., Focia, P.J., He, X.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.
Embo J., 26, 2007
2O27
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STRUCTURE OF A CLASS III RTK SIGNALING ASSEMBLY
Descriptor:Kit ligand
Authors:Liu, H., Chen, X., Focia, P., He, X.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.
Embo J., 26, 2007
3G5C
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STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OF HUMAN ADAM22
Descriptor:ADAM 22, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Liu, H., Shim, A., Chen, X., He, X.
Deposit date:2009-02-04
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural and biochemical studies on the ectodomain of human ADAM22
J.Biol.Chem., 2009
3IZO
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MODEL OF THE FIBER TAIL AND ITS INTERACTIONS WITH THE PENTON BASE OF HUMAN ADENOVIRUS BY CRYO-ELECTRON MICROSCOPY
Descriptor:Penton protein, Fiber
Authors:Liu, H.
Deposit date:2010-11-05
Release date:2011-01-05
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Model of the Trimeric Fiber and Its Interactions with the Pentameric Penton Base of Human Adenovirus by Cryo-electron Microscopy.
J.Mol.Biol., 406, 2011
3JA4
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RNA-DEPENDENT RNA POLYMERASES OF TRANSCRIBING CYPOVIRUSES
Descriptor:RNA-dependent RNA polymerase
Authors:Liu, H., Cheng, L.
Deposit date:2015-04-20
Release date:2015-10-28
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.
Science, 349, 2015
3JA5
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GENOME AND RDRP STRUCTURE WITHIN THE CAPSID OF NO-TRANSCRIBING CYPOVIRUS
Descriptor:RNA-dependent RNA polymerase
Authors:Liu, H., Cheng, L.
Deposit date:2015-04-21
Release date:2015-10-28
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.
Science, 349, 2015
3NVN
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MOLECULAR MECHANISM OF GUIDANCE CUE RECOGNITION
Descriptor:EVM139, Plexin-C1, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Liu, H., Juo, Z., Shim, A., Focia, P., Chen, X., Garcia, C., He, X.
Deposit date:2010-07-08
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1.
Cell(Cambridge,Mass.), 142, 2010
3NVX
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MOLECULAR MECHANISM OF GUIDANCE CUE RECOGNITION
Descriptor:Protein A39, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, H., Juo, Z., Shim, A., Focia, P., Chen, X., Garcia, C., He, X.
Deposit date:2010-07-08
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1.
Cell(Cambridge,Mass.), 142, 2010
3P3Y
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CRYSTAL STRUCTURE OF NEUROFASCIN HOMOPHILIC ADHESION COMPLEX IN SPACE GROUP P6522
Descriptor:Neurofascin, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, H., He, X.
Deposit date:2010-10-05
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Homophilic adhesion mechanism of neurofascin, a member of the l1 family of neural cell adhesion molecules.
J.Biol.Chem., 286, 2011
3P40
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CRYSTAL STRUCTURE OF NEUROFASCIN ADHESION COMPLEX IN SPACE GROUP P3221
Descriptor:Neurofascin, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, H., He, X.
Deposit date:2010-10-05
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Homophilic adhesion mechanism of neurofascin, a member of the l1 family of neural cell adhesion molecules.
J.Biol.Chem., 286, 2011