Author results

3CYW
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EFFECT OF FLAP MUTATIONS ON STRUCTURE OF HIV-1 PROTEASE AND INHIBITION BY SAQUINAVIR AND DARUNAVIR
Descriptor:HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ...
Authors:Liu, F., Weber, I.T.
Deposit date:2008-04-27
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3CYX
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I50V AND INHIBITOR SAQUINAVIRA
Descriptor:HIV-1 Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, SODIUM ION, ...
Authors:Liu, F., Weber, I.T.
Deposit date:2008-04-27
Release date:2008-05-27
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3D1X
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54M AND INHIBITOR SAQUINAVIR
Descriptor:HIV-1 Protease, CHLORIDE ION, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ...
Authors:Liu, F., Weber, I.T.
Deposit date:2008-05-06
Release date:2008-06-03
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3D1Y
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR SAQUINA
Descriptor:HIV-1 Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Liu, F., Weber, I.T.
Deposit date:2008-05-06
Release date:2008-05-27
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3D1Z
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54M AND INHIBITOR DARUNAVIR
Descriptor:HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ...
Authors:Liu, F., Kovalesky, A.Y., Tie, Y., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2008-05-07
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
3D20
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CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR DARUNAVIA
Descriptor:HIV-1 Protease, SODIUM ION, CHLORIDE ION, ...
Authors:Liu, F., Kovalesky, A.Y., Tie, Y., Ghosh, A.K., Harrison, R.W., Weber, I.T.
Deposit date:2008-05-07
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
J.Mol.Biol., 381, 2008
4ERO
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STUDY ON STRUCTURE AND FUNCTION RELATIONSHIPS IN HUMAN PIRIN WITH COBALT ION
Descriptor:Pirin, COBALT (II) ION, 1,2-ETHANEDIOL
Authors:Liu, F., Rehmani, I., Fu, R., Esaka, S., Chen, L., Serrano, V., Liu, A.
Deposit date:2012-04-20
Release date:2013-05-29
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EWA
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STUDY ON STRUCTURE AND FUNCTION RELATIONSHIPS IN HUMAN PIRIN WITH FE ION
Descriptor:Pirin, FE (III) ION
Authors:Liu, F., Rehmani, I., Chen, L., Fu, R., Serrano, V., Wilson, D.W., Liu, A.
Deposit date:2012-04-26
Release date:2013-05-29
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EWD
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STUDY ON STRUCTURE AND FUNCTION RELATIONSHIPS IN HUMAN PIRIN WITH MN ION
Descriptor:Pirin, MANGANESE (II) ION
Authors:Liu, F., Rehmani, I., Chen, L., Fu, R., Serrano, V., Wilson, D.W., Liu, A.
Deposit date:2012-04-26
Release date:2013-05-29
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EWE
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STUDY ON STRUCTURE AND FUNCTION RELATIONSHIPS IN HUMAN PIRIN WITH MANGANESE ION
Descriptor:Pirin, MANGANESE (II) ION, 1,2-ETHANEDIOL
Authors:Liu, F., Rehmani, I., Fu, R., Esaka, S., Chen, L., Serrano, V., Liu, A.
Deposit date:2012-04-26
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GUL
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STUDY ON STRUCTURE AND FUNCTION RELATIONSHIPS IN HUMAN FERRIC PIRIN
Descriptor:Pirin, FE (III) ION
Authors:Liu, F., Rehmani, I., Fu, R., Esaka, S., Chen, L., Serrano, V., Liu, A.
Deposit date:2012-08-29
Release date:2013-05-29
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HLT
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CRYSTAL STRUCTURE OF FERRIC E32V PIRIN
Descriptor:Pirin, FE (II) ION
Authors:Liu, F., Rehmani, I., Esaki, S., Fu, R., Chen, L., Serrano, V., Liu, A.
Deposit date:2012-10-17
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HSJ
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1.88 ANGSTROM X-RAY CRYSTAL STRUCTURE OF PICONLINIC-BOUND 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, PYRIDINE-2-CARBOXYLIC ACID
Authors:Liu, F., Chen, L., Davis, C.I., Liu, A.
Deposit date:2012-10-30
Release date:2015-05-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.883 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4HSL
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2.00 ANGSTROM X-RAY CRYSTAL STRUCTURE OF SUBSTRATE-BOUND E110A 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE FROM CUPRIAVIDUS METALLIDURANS
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, 3-HYDROXYANTHRANILIC ACID
Authors:Liu, F., Chen, L., Liu, A.
Deposit date:2012-10-30
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans
To be Published
4HVO
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1.75 ANGSTROM X-RAY CRYSTAL STRUCTURE OF CUFE RECONSTITUTED 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE FROM CUPRIAVIDUS METALLIDURANS
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, COPPER (II) ION, FE (II) ION
Authors:Liu, F., Chen, L., Liu, A.
Deposit date:2012-11-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4HVQ
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X-RAY CRYSTAL STRUCTURE OF FECU RECONSTITUTED 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE FROM CUPRIAVIDUS METALLIDURANS
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Liu, F., Chen, L., Liu, A.
Deposit date:2012-11-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4HVR
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X-RAY CRYSTAL STRUCTURE OF SALICYLIC ACID BOUND 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE FROM CUPRIAVIDUS METALLIDURANS
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (III) ION, 2-HYDROXYBENZOIC ACID
Authors:Liu, F., Chen, L., Liu, A.
Deposit date:2012-11-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystal structure of salicylic acid bound 3-hydroxyanthranilate-3,4-dioxygenase from cupriavidus metallidurans
To be Published
4I3P
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1.96 ANGSTROM X-RAY CRYSTAL STRUCTURE OF 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE BOUND WITH 3-AMINOSALICYLIC ACID FROM CUPRIAVIDUS METALLIDURANS
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, 3-amino-2-hydroxybenzoic acid
Authors:Liu, F., Liu, A.
Deposit date:2012-11-26
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:1.96 angstrom x-ray crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase bound with 3-aminosalicylic acid from cupraavidus metallidurans
TO BE PUBLISHED
4IGM
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2.39 ANGSTROM X-RAY CRYSTAL STRUCTURE OF HUMAN ACMSD
Descriptor:2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, ZINC ION
Authors:Liu, F., Liu, A.
Deposit date:2012-12-17
Release date:2014-05-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.391 Å)
Cite:2.39 Angstrom X-ray Crystal structure of human ACMSD
To be Published
4L2N
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UNDERSTANDING EXTRADIOL DIOXYGENASE MECHANISM IN NAD+ BIOSYNTHESIS BY VIEWING CATALYTIC INTERMEDIATES - LIGAND-FREE STRUCTURE
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, CHLORIDE ION, ...
Authors:Liu, F., Liu, A.
Deposit date:2013-06-04
Release date:2015-05-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.
J.Biol.Chem., 290, 2015
4WZC
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UNDERSTANDING EXTRADIOL DIOXYGENASE MECHANISM IN NAD+ BIOSYNTHESIS BY VIEWING CATALYTIC INTERMEDIATES - 2,3-CIS-4,5-TRANS ACMS BOUND TO I142A MUTANT HAO
Descriptor:3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION, (2E)-2-amino-3-[(1E)-3-oxoprop-1-en-1-yl]but-2-enedioic acid
Authors:Liu, F., Liu, A.
Deposit date:2014-11-19
Release date:2016-02-10
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.842 Å)
Cite:Probing Extradiol Dioxygenase Mechanism in NAD+ Biosynthesis by Viewing Reaction Cycle Intermediates
To Be Published
2AVM
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:HIV-1 protease, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVO
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, SULFATE ION, DIMETHYL SULFOXIDE, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVQ
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005
2AVS
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KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S
Descriptor:Pol polyprotein, PHOSPHATE ION, SULFATE ION, ...
Authors:Liu, F., Boross, P.I., Wang, Y.F., Tozser, J., Louis, J.M., Harrison, R.W., Weber, I.T.
Deposit date:2005-08-30
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
J.Mol.Biol., 354, 2005