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5CO5
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CRYSTAL STRUCTURE OF AC-ACHBP IN COMPLEX WITH CONOTOXIN GIC
分子名称:Soluble acetylcholine receptor, Alpha-conotoxin GIC
著者Wang, X.Q., Xu, M.Y., Luo, S.L., Lin, B.
登録日2015-07-19
公開日2016-07-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of Ac-AChBP in complex with conotoxin GIC
To Be Published
5IPI
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STRUCTURE OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
分子名称:Capsid protein VP1
著者Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
登録日2016-03-09
公開日2016-07-20
最終更新日2017-09-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5IPK
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STRUCTURE OF THE R432A VARIANT OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
分子名称:Capsid protein VP1
著者Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
登録日2016-03-09
公開日2016-07-20
最終更新日2017-09-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5WDF
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CRYSTAL STRUCTURE OF 10E8V4-5R+100CF FAB IN COMPLEX WITH HIV-1 GP41 PEPTIDE
分子名称:10E8v4-5R+100cF Fab heavy chain, FA10E8v4-5R+100cF FAB light chain, HIV-1 gp41 peptide
著者Kwon, Y.D., Kwong, P.D.
登録日2017-07-05
公開日2018-03-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.
Cell Rep, 22, 2018
6MTJ
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-378806 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 2.9 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-19
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.336 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MTN
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR COMPOUND 484 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.0 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-20
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MU6
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-814508 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.2 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-22
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MU7
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-818251 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.1 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-22
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MU8
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CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-386150 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.5 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-22
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.993 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MUF
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CRYSTAL STRUCTURE OF HIV-1 B41 SOSIP.664 PREFUSION ENV TRIMER IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.4 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-23
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MUG
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CRYSTAL STRUCTURE OF HIV-1 B41 SOSIP.664 PREFUSION ENV TRIMER BOUND TO SMALL MOLECULE HIV-1 ENTRY INHIBITOR BMS-386150 IN COMPLEX WITH HUMAN ANTIBODIES 3H109L AND 35O22 AT 3.8 ANGSTROM
分子名称:Envelope glycoprotein gp160, 35O22 scFv heavy chain portion, 35O22 scFv light chain portion, ...
著者Lai, Y.-T., Kwong, P.D.
登録日2018-10-23
公開日2019-01-16
実験手法X-RAY DIFFRACTION (2.954 Å)
主引用文献Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
3VDD
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STRUCTURE OF HRV2 CAPSID COMPLEXED WITH ANTIVIRAL COMPOUND BTA798
分子名称:Protein VP1, Protein VP2, Protein VP3, ...
著者Morton, C.J., Feil, S.C., Parker, M.W.
登録日2012-01-05
公開日2012-09-12
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
5DEY
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CRYSTAL STRUCTURE OF PAK1 IN COMPLEX WITH AN INHIBITOR COMPOUND G-5555
分子名称:Serine/threonine-protein kinase PAK 1, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
著者Oh, A., Tam, C., Wang, W.
登録日2015-08-26
公開日2016-01-27
最終更新日2016-06-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Acs Med.Chem.Lett., 6, 2015
5DFP
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CRYSTAL STRUCTURE OF PAK1 IN COMPLEX WITH AN INHIBITOR COMPOUND FRAX1036
分子名称:Serine/threonine-protein kinase PAK 1, 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, DIMETHYL SULFOXIDE
著者Maksimoska, J., Marmorstein, R., Wang, W.
登録日2015-08-27
公開日2016-01-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Acs Med.Chem.Lett., 6, 2015
5XVA
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CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH216
分子名称:Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone, ETHANOL
著者Zhao, F., Li, H.
登録日2017-06-27
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.847 Å)
主引用文献Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
5XVF
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CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH062
分子名称:Serine/threonine-protein kinase PAK 4, 2-(4-azanylpiperidin-1-yl)-6-chloranyl-N-(1-methylimidazol-4-yl)quinazolin-4-amine
著者Zhao, F., Li, H.
登録日2017-06-27
公開日2018-02-07
実験手法X-RAY DIFFRACTION (2.655 Å)
主引用文献Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
5XVG
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CRYSTAL STRUCTURE OF PAK4 IN COMPLEX WITH INHIBITOR CZH226
分子名称:Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone, ETHANOL, ...
著者Zhao, F., Li, H.
登録日2017-06-27
公開日2018-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J. Med. Chem., 61, 2018
6EGC
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SINGLE-CHAIN VERSION OF 2L4HC2_23 (PDB 5J0K)
分子名称:SC_2L4HC2_23
著者Bick, M.J., Chen, Z., DiMaio, F.
登録日2018-08-19
公開日2019-05-29
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Self-Assembling 2D Arrays with de Novo Protein Building Blocks.
J.Am.Chem.Soc., 141, 2019
6NPW
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SSU72/SYMPK IN COMPLEX WITH SER2/SER5 PHOSPHORYLATED PEPTIDE
分子名称:Symplekin, Ssu72 ortholog, LD40846p, ...
著者Irani, S., Zhang, Y.
登録日2019-01-18
公開日2019-04-24
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.486 Å)
主引用文献Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
J.Biol.Chem., 294, 2019
1NF1
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THE GAP RELATED DOMAIN OF NEUROFIBROMIN
分子名称:PROTEIN (NEUROFIBROMIN)
著者Scheffzek, K., Ahmadian, M.R., Wiesmueller, L., Kabsch, W., Stege, P., Schmitz, F., Wittinghofer, A.
登録日1998-07-08
公開日1999-07-20
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of the GAP-related domain from neurofibromin and its implications.
EMBO J., 17, 1998