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7Q3G
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BU of 7q3g by Molmil
Pentameric ligand-gated ion channel, DeCLIC at pH 7 with 10 mM Ca2+
Descriptor: CALCIUM ION, Neur_chan_LBD domain-containing protein
Authors:Licksell, M, Rovsnik, U, Hanke, A, Howard, R.J, Lindahl, E.
Deposit date:2021-10-27
Release date:2022-11-16
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel.
Proc.Natl.Acad.Sci.USA, 119, 2022
7Q3H
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BU of 7q3h by Molmil
Pentameric ligand-gated ion channel, DeCLIC at pH 7 with 10 mM EDTA
Descriptor: Neur_chan_LBD domain-containing protein
Authors:Lycksell, M, Rovsnik, U, Hanke, A, Howard, R.J, Lindahl, E.
Deposit date:2021-10-27
Release date:2022-11-16
Last modified:2022-12-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel.
Proc.Natl.Acad.Sci.USA, 119, 2022
8OQ7
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BU of 8oq7 by Molmil
CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
Authors:Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
Deposit date:2023-04-11
Release date:2023-08-30
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
8OQA
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BU of 8oqa by Molmil
CryoEM structure of human rho1 GABAA receptor in complex with GABA and picrotoxin
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
Deposit date:2023-04-11
Release date:2023-08-30
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
8OQ6
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BU of 8oq6 by Molmil
CryoEM structure of human rho1 GABAA receptor apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ...
Authors:Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
Deposit date:2023-04-11
Release date:2023-08-30
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
8OP9
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BU of 8op9 by Molmil
CryoEM structure of human rho1 GABAA receptor in complex with GABA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
Deposit date:2023-04-06
Release date:2023-08-30
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
8OQ8
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BU of 8oq8 by Molmil
CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ...
Authors:Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E.
Deposit date:2023-04-11
Release date:2023-08-30
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
6ERI
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BU of 6eri by Molmil
Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10 alpha, ...
Authors:Perez Borema, A, Aibara, S, Paul, B, Tobiasson, V, Kimanius, D, Forsberg, B.O, Wallden, K, Lindahl, E, Amunts, A.
Deposit date:2017-10-18
Release date:2018-04-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor.
Nat Plants, 4, 2018
8SWK
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BU of 8swk by Molmil
Cryo-EM structure of NLRP3 closed hexamer
Descriptor: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ...
Authors:Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S.
Deposit date:2023-05-18
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (4.32 Å)
Cite:Cryo-EM structures of NLRP3 reveal its self-activation mechanism
Nat Commun, 2024
8SWF
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BU of 8swf by Molmil
Cryo-EM structure of NLRP3 open octamer
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S.
Deposit date:2023-05-18
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Cryo-EM structures of NLRP3 reveal its self-activation mechanism
Nat Commun, 2024
8SXN
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BU of 8sxn by Molmil
Structure of NLRP3 and NEK7 complex
Descriptor: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ...
Authors:Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S.
Deposit date:2023-05-22
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Cryo-EM structures of NLRP3 reveal its self-activation mechanism
Nat Commun, 2024
8SGO
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BU of 8sgo by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E.
Deposit date:2023-04-12
Release date:2023-08-30
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
8B7V
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BU of 8b7v by Molmil
Automated simulation-based refinement of maltoporin into a cryo-EM density
Descriptor: Maltoporin
Authors:Yvonnesdotter, L, Rovsnik, U, Blau, C, Lycksell, M, Howard, R.J, Lindahl, E.
Deposit date:2022-10-03
Release date:2023-06-21
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Automated simulation-based membrane protein refinement into cryo-EM data.
Biophys.J., 122, 2023
8ATG
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BU of 8atg by Molmil
Pentameric ligand-gated ion channel GLIC with bound lipids
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Proton-gated ion channel
Authors:Bergh, C, Rovsnik, U, Howard, R.J, Lindahl, E.
Deposit date:2022-08-23
Release date:2023-09-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM.
Elife, 12, 2024
6ZGD
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BU of 6zgd by Molmil
GLIC pentameric ligand-gated ion channel, pH 7
Descriptor: Proton-gated ion channel
Authors:Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E.
Deposit date:2020-06-18
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
6ZGJ
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BU of 6zgj by Molmil
GLIC pentameric ligand-gated ion channel, pH 5
Descriptor: Proton-gated ion channel
Authors:Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E.
Deposit date:2020-06-18
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
6ZGK
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BU of 6zgk by Molmil
GLIC pentameric ligand-gated ion channel, pH 3
Descriptor: Proton-gated ion channel
Authors:Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E.
Deposit date:2020-06-18
Release date:2021-05-26
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.
Life Sci Alliance, 4, 2021
6ZLO
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BU of 6zlo by Molmil
E2 core of the fungal Pyruvate dehydrogenase complex with asymmetric interior PX30 component
Descriptor: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Authors:Forsberg, B.O, Howard, R.J, Aibara, S, Mortesaei, N, Lindahl, E.
Deposit date:2020-06-30
Release date:2020-09-23
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex.
Nat Commun, 11, 2020
6PV8
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BU of 6pv8 by Molmil
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Descriptor: (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E.
Deposit date:2019-07-19
Release date:2019-09-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Neuron, 104, 2019
6PV7
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BU of 6pv7 by Molmil
Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E.
Deposit date:2019-07-19
Release date:2019-09-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Neuron, 104, 2019
6X3Z
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BU of 6x3z by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3V
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BU of 6x3v by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Etomidate, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3T
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BU of 6x3t by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3W
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BU of 6x3w by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3U
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BU of 6x3u by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020

 

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