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5HLO
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CRYSTAL STRUCTURE OF CALCIUM AND ZINC-BOUND HUMAN S100A8 IN SPACE GROUP C2221
Descriptor:Protein S100-A8, CALCIUM ION, ZINC ION, ...
Authors:Lin, H., Andersen, G.R., Yatime, L.
Deposit date:2016-01-15
Release date:2016-06-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human S100A8 in complex with zinc and calcium.
Bmc Struct.Biol., 16, 2016
5HLV
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CRYSTAL STRUCTURE OF CALCIUM AND ZINC-BOUND HUMAN S100A8 IN SPACE GROUP P212121
Descriptor:Protein S100-A8, CALCIUM ION, ZINC ION, ...
Authors:Lin, H., Andersen, G.R., Yatime, L.
Deposit date:2016-01-15
Release date:2016-06-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human S100A8 in complex with zinc and calcium.
Bmc Struct.Biol., 16, 2016
6IS8
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CRYSTAL STRUCTURE OF ZMMOC1 D115N MUTANT IN COMPLEX WITH HOLLIDAY JUNCTION
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), MAGNESIUM ION, ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2018-11-15
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6IS9
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CRYSTAL STRUCTURE OF ZMMOC1
Descriptor:Monokaryotic chloroplast 1
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2018-11-15
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6JRF
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CRYSTAL STRUCTURE OF ZMMOC1-HOLLIDAY JUNCTION COMPLEX IN THE PRESENCE OF CALCIUM
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), CALCIUM ION, ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6JRG
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CRYSTAL STRUCTURE OF ZMMOC1 H253A MUTANT IN COMPLEX WITH HOLLIDAY JUNCTION
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), DNA (32-MER), ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1.
Nat.Chem.Biol., 2019
6K1S
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DISCOVERY OF POTENT AND SELECTIVE COVALENT PROTEIN ARGININE METHYLTRANSFERASE (PRMT5) INHIBITORS
Descriptor:Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, ...
Authors:Tong, S., Lin, H.
Deposit date:2019-05-12
Release date:2019-06-19
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Acs Med.Chem.Lett., 10, 2019
3ZJ6
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CRYSTAL OF RAUCAFFRICINE GLUCOSIDASE IN COMPLEX WITH INHIBITOR
Descriptor:RAUCAFFRICINE-O-BETA-D-GLUCOSIDASE, SULFATE ION, (1R,2S,3S,4R,5R)-4-(cyclohexylmethylamino)-5-(hydroxymethyl)cyclopentane-1,2,3-triol
Authors:Xia, L., Lin, H., Panjikar, S., Ruppert, M., Castiglia, A., Rajendran, C., Wang, M., Schuebel, H., Warzecha, H., Jaeger, V., Stoeckigt, J.
Deposit date:2013-01-17
Release date:2014-01-29
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours.
J.Enzyme.Inhib.Med.Chem., 30, 2015
3DZF
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN COMPLEXED WITH A COVALENT INTERMEDIATE, ARA-F-RIBOSE-5'-PHOSPHATE
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZG
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, ARA-F-RIBOSE-5'-PHOSPHATE/NICOTINAMIDE COMPLEX
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, NICOTINAMIDE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZH
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, GTP COMPLEX
Descriptor:ADP-ribosyl cyclase 1, GUANOSINE-5'-TRIPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZI
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, RIBOSE-5'-PHOSPHATE INTERMEDIATE/GTP COMPLEX
Descriptor:ADP-ribosyl cyclase 1, 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, ...
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZJ
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN E226Q MUTANT, NMN COMPLEX
Descriptor:ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3DZK
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CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, NMN COMPLEX
Descriptor:ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q.
Deposit date:2008-07-29
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
3I9J
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH A SUBSTRATE ANALOG AND A PRODUCT NICOTINAMIDE
Descriptor:ADP-ribosyl cyclase, Nicotinamide 2-fluoro-adenine dinucleotide, [(2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9K
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH SUBSTRATE NAD
Descriptor:ADP-ribosyl cyclase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9L
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH N1-CIDPR
Descriptor:ADP-ribosyl cyclase, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9M
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CRYSTAL STRUCTURE OF HUMAN CD38 COMPLEXED WITH AN ANALOG ARA-2'F-ADPR
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9N
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CRYSTAL STRUCTURE OF HUMAN CD38 COMPLEXED WITH AN ANALOG RIBO-2'F-ADP RIBOSE
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3ZJ7
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CRYSTAL STRUCTURE OF STRICTOSIDINE GLUCOSIDASE IN COMPLEX WITH INHIBITOR-1
Descriptor:STRICTOSIDINE-O-BETA-D-GLUCOSIDASE, (1R,2S,3S,4R,5R)-4-(cyclohexylamino)-5-(hydroxymethyl)cyclopentane-1,2,3-triol
Authors:Xia, L., Lin, H., Panjikar, S., Ruppert, M., Castiglia, A., Rajendran, C., Wang, M., Schuebel, H., Warzecha, H., Jaeger, V., Stoeckigt, J.
Deposit date:2013-01-17
Release date:2014-02-05
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours.
J.Enzyme.Inhib.Med.Chem., 30, 2015
3ZJ8
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CRYSTAL STRUCTURE OF STRICTOSIDINE GLUCOSIDASE IN COMPLEX WITH INHIBITOR-2
Descriptor:STRICTOSIDINE-O-BETA-D-GLUCOSIDASE, (1R,2S,3S,4R,5R)-4-[(4-bromophenyl)methylamino]-5-(hydroxymethyl)cyclopentane-1,2,3-triol
Authors:Xia, L., Lin, H., Panjikar, S., Ruppert, M., Castiglia, A., Rajendran, C., Wang, M., Schuebel, H., Warzecha, H., Jaeger, V., Stoeckigt, J.
Deposit date:2013-01-17
Release date:2014-02-05
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours.
J.Enzyme.Inhib.Med.Chem., 30, 2015
4EXN
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CRYSTAL STRUCTURE OF MOUSE INTERLEUKIN-34
Descriptor:Interleukin-34, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Liu, H., Leo, C., Chen, X., Wong, B.R., Williams, L.T., Lin, H., He, X.
Deposit date:2012-04-30
Release date:2012-05-30
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
4EXP
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STRUCTURE OF MOUSE INTERLEUKIN-34 IN COMPLEX WITH MOUSE FMS
Descriptor:Interleukin-34, Macrophage colony-stimulating factor 1 receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Liu, H., Leo, C., Chen, X., Wong, B.R., Williams, L.T., Lin, H., He, X.
Deposit date:2012-04-30
Release date:2012-05-30
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
2AIU
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CRYSTAL STRUCTURE OF MOUSE TESTICULAR CYTOCHROME C AT 1.6 ANGSTROM
Descriptor:Cytochrome c, testis-specific, PHOSPHATE ION, ...
Authors:Liu, Z., Ye, S., Lin, H., Rao, Z., Liu, X.J.
Deposit date:2005-08-01
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis
Proc.Natl.Acad.Sci.Usa, 103, 2006
2KXQ
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SOLUTION STRUCTURE OF SMURF2 WW2 AND WW3 BOUND TO SMAD7 PY MOTIF CONTAINING PEPTIDE
Descriptor:E3 ubiquitin-protein ligase SMURF2, Smad7 PY motif containing peptide
Authors:Chong, A., Lin, H., Wrana, J., Forman-Kay, J.D.
Deposit date:2010-05-11
Release date:2010-10-13
Last modified:2012-06-20
Method:SOLUTION NMR
Cite:Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.
Proc.Natl.Acad.Sci.USA, 107, 2010