8JHG
| Native SUV420H1 bound to 167-bp nucleosome | Descriptor: | DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Lin, F, Li, W. | Deposit date: | 2023-05-23 | Release date: | 2023-11-22 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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8JHF
| Native SUV420H1 bound to 167-bp nucleosome | Descriptor: | DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ... | Authors: | Lin, F, Li, W. | Deposit date: | 2023-05-23 | Release date: | 2023-11-15 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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1NWV
| SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR | Descriptor: | Complement decay-accelerating factor | Authors: | Uhrinova, S, Lin, F, Ball, G, Bromek, K, Uhrin, D, Medof, M.E, Barlow, P.N. | Deposit date: | 2003-02-07 | Release date: | 2003-04-22 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of a functionally active fragment of decay-accelerating factor Proc.Natl.Acad.Sci.USA, 100, 2003
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1M11
| structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy | Descriptor: | COAT PROTEIN VP1, COAT PROTEIN VP2, COAT PROTEIN VP3, ... | Authors: | He, Y, Lin, F, Chipman, P.R, Bator, C.M, Baker, T.S, Shoham, M, Kuhn, R.J, Medof, M.E, Rossmann, M.G. | Deposit date: | 2002-06-17 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (16 Å) | Cite: | Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc.Natl.Acad.Sci.USA, 99, 2002
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2QZH
| SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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2QZF
| SCR1 of DAF from 1ojv fitted into cryoEM density | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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2QZD
| Fitted structure of SCR4 of DAF into cryoEM density | Descriptor: | Complement decay-accelerating factor | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | Deposit date: | 2007-08-16 | Release date: | 2007-10-30 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3. J.Virol., 81, 2007
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3IYP
| The Interaction of Decay-accelerating Factor with Echovirus 7 | Descriptor: | Capsid protein, Complement decay-accelerating factor, LAURIC ACID, ... | Authors: | Plevka, P, Hafenstein, S, Zhang, Y, Harris, K.G, Cifuente, J.O, Bowman, V.D, Chipman, P.R, Lin, F, Medof, D.E, Bator, C.M, Rossmann, M.G. | Deposit date: | 2010-04-07 | Release date: | 2010-11-24 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Interaction of decay-accelerating factor with echovirus 7. J.Virol., 84, 2010
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2AIZ
| Solution structure of peptidoglycan associated lipoprotein from Haemophilus influenza bound to UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine | Descriptor: | L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine, N-acetyl-beta-muramic acid, Outer membrane protein P6 (Fragment), ... | Authors: | Parsons, L.M, Lin, F, Orban, J, Structure 2 Function Project (S2F) | Deposit date: | 2005-08-01 | Release date: | 2006-03-14 | Last modified: | 2023-02-15 | Method: | SOLUTION NMR | Cite: | Peptidoglycan recognition by pal, an outer membrane lipoprotein. Biochemistry, 45, 2006
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2CH0
| Solution structure of the human MAN1 C-terminal domain (residues 655- 775) | Descriptor: | INNER NUCLEAR MEMBRANE PROTEIN MAN1 | Authors: | Caputo, S, Couprie, J, Duband-Goulet, I, Lin, F, Braud, S, Gondry, M, Worman, H.J, Gilquin, B, Zinn-Justin, S. | Deposit date: | 2006-03-10 | Release date: | 2006-05-16 | Last modified: | 2018-05-02 | Method: | SOLUTION NMR | Cite: | The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain. J. Biol. Chem., 281, 2006
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1YZ3
| Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139 | Descriptor: | 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Wu, Q, Gee, C.L, Lin, F, Martin, J.L, Grunewald, G.L, McLeish, M.J. | Deposit date: | 2005-02-27 | Release date: | 2006-02-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase J.Med.Chem., 48, 2005
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8GY0
| Agrocybe pediades linalool sunthase (Ap.LS) | Descriptor: | Terpene synthase | Authors: | Rehka, T, Sharma, D, Lin, F, Lim, C, Choong, Y.K, Chacko, J, Zhang, C. | Deposit date: | 2022-09-21 | Release date: | 2023-04-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.988 Å) | Cite: | Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products. Acs Catalysis, 13, 2023
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5FA5
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7R6H
| RHCC in complex with o-carborane | Descriptor: | Tetrabrachion, ortho-carborane | Authors: | Heide, F, McDougall, M, Stetefeld, J. | Deposit date: | 2021-06-22 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Boron rich nanotube drug carrier system is suited for boron neutron capture therapy. Sci Rep, 11, 2021
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6LKA
| Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | Descriptor: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | Deposit date: | 2019-12-18 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.033 Å) | Cite: | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorg.Med.Chem., 28, 2020
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7MBI
| Structure of SARS-CoV2 3CL protease covalently bound to peptidomimetic inhibitor | Descriptor: | 2,4,6-trimethylpyridine-3-carboxylic acid, 3C-like proteinase, 4-methoxy-N-[(2S)-4-methyl-1-oxo-1-({(2S)-3-oxo-1-[(3S)-2-oxopiperidin-3-yl]butan-2-yl}amino)pentan-2-yl]-1H-indole-2-carboxamide | Authors: | Khan, M.B, Lu, J, Young, H.S, Lemieux, M.J. | Deposit date: | 2021-03-31 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Peptidomimetic alpha-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. J.Med.Chem., 65, 2022
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6W9T
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5SUN
| IDH1 R132H in complex with IDH146 | Descriptor: | 1,2-ETHANEDIOL, 3-benzyl-N-[3-(dimethylsulfamoyl)phenyl]-4-oxo-3,4-dihydrophthalazine-1-carboxamide, DIMETHYL SULFOXIDE, ... | Authors: | Xie, X, Kulathila, R. | Deposit date: | 2016-08-03 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.477 Å) | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
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5SVF
| IDH1 R132H in complex with IDH125 | Descriptor: | (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | Authors: | Xie, X, Kulathila, R. | Deposit date: | 2016-08-05 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
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5SVO
| Structure of IDH2 mutant R140Q | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Isocitrate dehydrogenase [NADP], mitochondrial, ... | Authors: | Xie, X, Kulathila, R. | Deposit date: | 2016-08-06 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
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5SVN
| Structure of IDH2 mutant R172K | Descriptor: | DI(HYDROXYETHYL)ETHER, Isocitrate dehydrogenase [NADP], mitochondrial, ... | Authors: | Xie, X, Kulathila, R. | Deposit date: | 2016-08-06 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25, 2017
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1NL6
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1NLJ
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2X5I
| Crystal structure echovirus 7 | Descriptor: | LAURIC ACID, VP1, VP2, ... | Authors: | Plevka, P, Hafenstein, S, Zhang, Y, Bowman, V.D, Chipman, P.R, Bator, C.M, Rossmann, M.G. | Deposit date: | 2010-02-08 | Release date: | 2010-12-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Interaction of Decay-Accelerating Factor with Echovirus 7. J.Virol., 84, 2010
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6HKY
| Eg5-inhibitor complex | Descriptor: | (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Talapatra, S.K, Kozielski, F. | Deposit date: | 2018-09-09 | Release date: | 2019-09-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes. Mol.Cancer Ther., 18, 2019
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